METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE

Product Name: METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE
CAS No.: 6232-11-7
Chemical Name: METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE
Synonyms: BUTTPARK 33\11-77;4-(Aminomethyl)benzoate hcl;Methyl4-(aminomethyl)benzoateHCl;4-(Aminomethyl)benzoate monohydrochloride;4-METHOXYCARBONYL-BENZYLAMINE HYDROCHLORIDE;METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE;Methyl p-(Aminomethyl)benzoate Hydrochloride;Methyl4-(Aminomethyl)benzoateHydrochloride>Methyl 4-(aMinoMethyl)benzoate hydrochloride 97%;Methyl 4-(aminomethyl)benzoate hydrochloride,97%
CBNumber: CB1295456
Molecular Formula: C9H12ClNO2
Formula Weight: 201.65
MOL File: 6232-11-7.mol

More

Less

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Property

Melting point:: 243 °C (dec.)(lit.)
storage temp.: Inert atmosphere,Room Temperature
form: Crystalline Powder
color: White
InChI: InChI=1S/C9H11NO2.ClH/c1-12-9(11)8-4-2-7(6-10)3-5-8;/h2-5H,6,10H2,1H3;1H
InChIKey: GIZCKBSSWNIUMZ-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(CN)C=C1.[H]Cl
CAS DataBase Reference: 6232-11-7

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224999

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 479993
Product name: Methyl 4-(aminomethyl)benzoate hydrochloride
Purity: 97%
Packaging: 5g
Price: $52.25
Updated: 2025/07/31

TCI Chemical

Product number: M2200
Product name: Methyl 4-(Aminomethyl)benzoate Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: M2200
Product name: Methyl 4-(Aminomethyl)benzoate Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $149
Updated: 2025/07/31

TRC

Product number: M332840
Product name: Methyl 4-(Aminomethyl)benzoate Hydrochloride
Packaging: 10g
Price: $140
Updated: 2021/12/16

TRC

Product number: M332840
Product name: Methyl 4-(Aminomethyl)benzoate Hydrochloride
Packaging: 250mg
Price: $45
Updated: 2021/12/16

More

Less

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

Methyl 4-(aminomethyl)benzoate hydrochloride may be used in the preparation of methyl 4-((3-butyl-3-phenylureido)methyl)benzoate.

General Description

Methyl 4-(aminomethyl)benzoate hydrochloride is an amino acid ester hydrochloride. Its synthesis by esterification reaction has been reported. It plays a role during the preparation of a novel hepatitis C virus (HCV) helicase inhibitor.

Synthesis

56-91-7

6232-11-7

4-(Aminomethyl)benzoic acid (302 mg, 2.00 mmol) was dissolved in methanol (30 mL) and thionyl chloride (1.16 mL, 16.0 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature overnight. Subsequently, the solvent was removed by distillation under reduced pressure to afford the target product, methyl 4-aminomethylbenzoate hydrochloride (15d), as a colorless solid in 390 mg (97%) yield with a melting point of 234 °C. The molecular formula was C9H12ClNO2 (molecular weight 201.7). Thin layer chromatography (TLC) analysis showed an Rf value of 0.22 (Expanding agent: ethyl acetate/1% diethylmethylamine, detection wavelength 254 nm). Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO-D6) showed chemical shifts δ [ppm]: 3.86 (single peak, 3H, CO2CH3), 4.10 (single peak, 2H, H3NCH2), 7.63-7.67 (multiple peaks, 2H, 3-HB, 5-HB), 7.96-8.01 (multiple peaks, 2H, 2-HB, 6 -HB), 8.61 (broad peaks, 3H, NH3). Nuclear magnetic resonance carbon spectra (13C NMR, 101 MHz, DMSO-D6) showed chemical shifts δ [ppm]: 41.7 (1C, H3NCH2), 52.2 (1C, CO2CH3), 129.2 (2C, C-3B, C-5B), 129.3 (2C, C-2B, C-6B), 129.5 (1C, C-1B). 139.4 (1C, C-4B), 165.9 (1C, CO2CH3). Fourier transform infrared spectroscopy (FT-IR) showed absorption peaks ν [cm-1]: 2963 (NH3+), 2878 (C-H aliphatic), 2573 (NH3+), 1678 (C=O), 1597, 1578, 1477 (C=C aromatic), and 864 (aromatic ring out-of-plane bending vibration). High resolution mass spectrometry (HRMS, APCI) showed m/z = 166.0865 (calculated value C9H12NO2 [M+H]+: 166.0863). High performance liquid chromatography (HPLC) analysis showed retention time tR = 6.4 min and purity 99.9%.

References

[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 21, p. 4872 - 4875
[2] European Journal of Medicinal Chemistry, 2017, vol. 129, p. 124 - 134
[3] Patent: US5585381, 1996, A

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Suppliers

Americas 1 Belgium 1 China 123 Europe 1 France 1 Germany 1 India 4 Japan 1 Switzerland 1 United Kingdom 3 United States 15 Global 152

YangZhou Ruihong Biotech Co., Ltd.

Tel: 0514-15380367604 15850576331
Email: 591834516@qq.com
Country: China
ProdList: 686
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Sci General Material & Chemical Ltd

Tel: 021-58388037;21-58388037 13472507714
Email: 35177634@qq.com;1589045147@qq.com
Country: China
ProdList: 803
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

6232-11-7, METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDERelated Search:

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE METHYL 3-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Methyl benzoate 4-(Aminomethyl)benzoic acid Benzylamine hydrochloride METHYL 3-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Methyl3-(aminomethyl)-4-chlorobenzoate hydrochloride

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE

4-METHOXYCARBONYL-BENZYLAMINE HYDROCHLORIDE

4-(AMINOMETHYL)BENZOIC ACID METHYL ESTER HYDROCHLORIDE

BUTTPARK 33\11-77

Methyl4-(aminomethyl)benzoateHCl

Methyl 4-(aminomethyl)benzoate hydrochloride,97%

4-(Aminomethyl)benzoate monohydrochloride

Benzoic acid, 4-(aminomethyl)-, methyl ester, hydrochloride (1:1)

4-(Methoxycarbonyl)benzylamine hydrochloride, [4-(Methoxycarbonyl)phenyl]methylamine hydrochloride

Methyl 4-(aMinoMethyl)benzoate hydrochloride 97%

4-(Aminomethyl)benzoate hcl

Methyl p-(Aminomethyl)benzoate Hydrochloride

Methyl4-(Aminomethyl)benzoateHydrochloride&gt

Benzenesulfonylchloride,4-methoxy-2-methyl-5-(6-methylethyl)-

4-(aminomethyl)-Benzoic acid methyl ester hydrochloride (1:1)

6232-11-7

H2NCH2C6H4CO2CH3HCl

AMINE

Building Blocks

C8 to C9

Carbonyl Compounds

Esters

Organic Building Blocks

DY-25G

C8 to C9

Carbonyl Compounds

Esters