Nebivolol

ChemicalBook > CAS DataBase List > Nebivolol

Product Name: Nebivolol
CAS No.: 99200-09-6
Chemical Name: Nebivolol
Synonyms: R-65824;Nebivolol;Nibivolol;NEBIVOLOL-D4;NEBIVOLOL-D6;(Rac)-Nebivolol;Nebilolol impurity 11;Nebivolol (10mM in DMSO);rac-Nebivolol (Mixture of Diastereomers);2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
CBNumber: CB1295698
Molecular Formula: C22H25F2NO4
Formula Weight: 405.43
MOL File: 99200-09-6.mol

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Nebivolol Property

Boiling point:: 600.5±55.0 °C(Predicted)
Density: 1.309±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 14.29±0.20(Predicted)
color: White to Off-White
InChI: InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/s3/i11D2,12D2
InChIKey: KOHIRBRYDXPAMZ-AWIIVWKDNA-N
SMILES: C([2H])([2H])([C@H](O)[C@@]1([H])CCC2C=C(C=CC=2O1)F)NC([2H])([2H])[C@H](O)[C@]1([H])CCC2C=C(C=CC=2O1)F |&1:3,5,21,23,r|
CAS DataBase Reference: 99200-09-6(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: N387933
Product name: Nebivolol
Packaging: 10mg
Price: $180
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: ND34423
Product name: (S,R,R,R)-Nebivolol-d2,15Nhydrochloride
Packaging: 5mg
Price: $1690
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0031361
Product name: NEBIVOLOL
Purity: 95.00%
Packaging: 100G
Price: $5699.93
Updated: 2021/12/16

Ambeed

Product number: A753261
Product name: 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
Purity: 98%
Packaging: 100mg
Price: $93
Updated: 2021/12/16

Ambeed

Product number: A753261
Product name: 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
Purity: 98%
Packaging: 250mg
Price: $170
Updated: 2021/12/16

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Nebivolol Chemical Properties,Usage,Production

Description

Nebilet was launched in Germany and the Netherlands as an antihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4- oxobenzopyran-2-carboxylic acid. It is a selective β₁-adrenergic receptor antagonist and is 50 times less potent at β₂-receptors. Vasodialating properties occur via the nitric oxide pathway. While the L-isomer is more potent than the D-isomer, the racemic mixture is necessary for optimal activity. Upon administration, an immediate fall in blood pressure occurs, it improves both left ventricular systolic and diastolic function, and lowers peripheral blood resistance. Nebilet does not influence insulin sensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10 mg of Nebilet are equipotent but Nebilet has a longer duration of action due to an accumulation of the drug and increasing plasma levels of active metabolites.

Originator

Johnson & Johnson (US)

Uses

Nebivolol is a cardioselective beta-1 receptor blocking agent.

Uses

Labeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry.

Definition

ChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.

brand name

Nebilet

Nebivolol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nebivolol manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: nebivolol 99200-09-6
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Nebivolol 99200-09-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Longyan Tianhua Biological Technology Co., Ltd

Product: Nebivolol 99200-09-6
Price: US $21.00/Kg/Bag
Min. Order: 25Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-09

99200-09-6, NebivololRelated Search:

Propanolol Ethanol Atenolol 1-Hydroxyethylidene-1,1-diphosphonic acid N,N-Diisopropylethylamine Ethyl acrylate Ethylparaben Ethyl cellulose Diethylenetriamine Metoprolol CHLOROPHOSPHONAZO III 2-(2-Aminoethylamino)ethanol Ethyl acetate Esmolol Bisoprolol Diethyltoluenediamine Ethylbenzene Diethyl ether

NEBIVOLOL-D4

1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol

Nibivolol

Nebivolol Impurity 6(rac-Nebivolol (Mixture of Diastereomers))

2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol)

rac-Nebivolol (Mixture of Diastereomers)

1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]ethanol

R-65824

α,α'-(Iminobismethylene)bis(6-fluoro-2-chromanmethanol)

2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]

Nebivolol

1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol

1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxy-ethyl]amino]ethanol

(1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-{[(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]aMino}ethan-1-ol

2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-

Nebivolol (10mM in DMSO)

(Rac)-Nebivolol

2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)

NEBIVOLOL-D6

Rac-NebivololQ: What is Rac-Nebivolol Q: What is the CAS Number of Rac-Nebivolol Q: What is the storage condition of Rac-Nebivolol Q: What are the applications of Rac-Nebivolol

2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol)

(RS)-1-((RS)-6-fluorochroman-2-yl)-2-(((RS)-2-((SR)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol

Nebilolol impurity 11

99200-09-6

C22H25F2NO4

C22H21F2NO4D4

Antihypertensive