PHENPROCOUMON
- Product Name
- PHENPROCOUMON
- CAS No.
- 435-97-2
- Chemical Name
- PHENPROCOUMON
- Synonyms
- MARCUMA;Fencumar;Liquamar;Marcumar;Falithrom;Falithiom;Marcoumar;RO 1-4849;Phenprocumon;PHENPROCOUMON
- CBNumber
- CB1295890
- Molecular Formula
- C18H16O3
- Formula Weight
- 280.32
- MOL File
- 435-97-2.mol
PHENPROCOUMON Property
- Melting point:
- 179-180°
- Boiling point:
- 463.2±45.0 °C(Predicted)
- Density
- 1.261±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.50±1.00(Predicted)
- color
- White to Off-White
- EPA Substance Registry System
- Phenprocoumon (435-97-2)
Safety
- RIDADR
- 2811
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 435-97-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
H370Causes damage to organs
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P307+P311IF exposed: call a POISON CENTER or doctor/physician.
P311Call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P318820
- Product name
- Phenprocoumon
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 165912
- Product name
- Phenprocoumon
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- P318820
- Product name
- Phenprocoumon
- Packaging
- 1g
- Price
- $775
- Updated
- 2021/12/16
- Product number
- P318820
- Product name
- Phenprocoumon
- Packaging
- 500mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- API0003816
- Product name
- PHENPROCOUMON
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $450
- Updated
- 2021/12/16
PHENPROCOUMON Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Liquamar ,Organon ,US,1958
Uses
Phenprocoumon is known for being an oral anti-coagulant.
Definition
ChEBI: A hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenylpropyl group.
Manufacturing Process
8.3 parts by weight of powdered sodium in 300 parts by volume of benzene, 100 parts by weight of diethyl (1'-phenylpropyl)-malonate and 72 parts by weight of acetylsalicylic acid chloride are reacted together to form diethyl 1(o-acetoxybenzoy1)-1-(1'-phenylpropyl)malonate, which boils at 195°198°C/0.03 mm Hg.
10.3 parts of weight of diethyl 1-(o-acetoxybenzoyl)-1-(1'-phenylpropyl)malonate are dissolved in 60 parts by volume of absolute ether and to this solution are added portion. wise at 10°C, while stirring, 2.6 parts by weight of sodium methylate. The reaction mixture is stirred for 4 hours, whereupon it is poured into ice water. The ether solution is washed neutral with ice water. After having distilled off the ether, a thick oil consisting of 3-carbethoxy-3-(1'phenylpropyl)-4-oxo-dihydrocoumarinis obtained. This compound crystallized in butyl oxide and has a MP of 108°-109°C.
The 3-carbethoxy-3-(1'-phenylpropyl)-4-oxo-dihydrocoumarinmay be hydrolyzed and decarboxylated as follows. The crude product is heated to 85°C for 1/2 hour with 100 parts by volume of 5% aqueous sodium hydroxide, while agitating or stirring. To remove traces of undissolved oil, the cooled solution is treated with 1 part by weight of charcoal, whereupon it is filtrated and acidified to Congo reaction with dilute sulfuric acid. The 3-(1'phenylpropyl)-4-hydroxycoumarin formed is separated off and recrystallized in 80% ethanol, whereupon it melts at 178°-179°C according to US Patent 2,701,804.
brand name
Liquamar (Organon).
Therapeutic Function
Anticoagulant
Synthesis
Phenprocoumon, 3-(|á-ethylbenzyl)-4-hydroxycoumarin (24.1.14), is synthesized by acylating sodium salts of diethyl ester (1-phenylpropyl)butyric acid with acetylsalicylic acid chloride, which forms the compound 24.1.12, which upon reaction with sodium ethoxide cyclizes to 3-(|á-ethylbenzyl)-2-carboethoxy-4-hydroxycoumarin (24.1.13). Alkaline hydrolysis of this product and further decarboxylation gives phenprocoumon(24.1.14).
PHENPROCOUMON Preparation Products And Raw materials
Raw materials
Preparation Products
PHENPROCOUMON Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- +8613162137806 18575662672
- Fax
- 021 51613951
- mzeng@3wpharm.com
- Country
- China
- ProdList
- 9746
- Advantage
- 57
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 027-87342388 18086026008
- Fax
- 027-87342388
- sales@kaymke.com
- Country
- China
- ProdList
- 4123
- Advantage
- 55
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17994
- Advantage
- 56
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 021-61984905-1 18016477331
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6455
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15952
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55896
- Advantage
- 58
- Tel
- +86-023-62871537
- sales@rosewachem.com
- Country
- China
- ProdList
- 2828
- Advantage
- 58
- Tel
- 755-36694831 +8613798234863
- Linda.zhou@debayer.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- CHINA
- ProdList
- 52867
- Advantage
- 58
- Tel
- 0571-85134551 18958018566;
- Fax
- 008657185134895
- info@afinechem.com
- Country
- China
- ProdList
- 15377
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58
- Tel
- 029-61856359 18690052321
- Fax
- 029-88380327
- 1027@dideu.com
- Country
- China
- ProdList
- 10008
- Advantage
- 58
- Tel
- 027-87747081 18186681184
- 1344475572@qq.com
- Country
- China
- ProdList
- 7243
- Advantage
- 58
- Tel
- 15869524721
- 3525679403@qq.com
- Country
- China
- ProdList
- 3695
- Advantage
- 58
- Tel
- +8613063595538
- donboo@donboo.com
- Country
- China
- ProdList
- 9365
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7955
- Advantage
- 58
- Tel
- --
- Fax
- --
- sarah@mainchem.com
- Country
- China
- ProdList
- 6572
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 9946
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 7977
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6712
- Advantage
- 58
- Tel
- 021-38218169 13341702378
- 190129269@qq.com
- Country
- China
- ProdList
- 9111
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24023
- Advantage
- 58
- Tel
- 0371-53370800 18037197114
- 2853031799@qq.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29803
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 11572
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50471
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 8740
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48467
- Advantage
- 58
- Tel
- 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 5347
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32686
- Advantage
- 60
- Tel
- 008657128800458; +8615858145714
- Fax
- +86-571-56059825
- fandachem@gmail.com
- Country
- China
- ProdList
- 9341
- Advantage
- 55
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43348
- Advantage
- 58
- Tel
- +8618327326525
- masar@topule.com
- Country
- China
- ProdList
- 8474
- Advantage
- 58
- Tel
- +8618058761490
- info@gihichemicals.com
- Country
- China
- ProdList
- 50000
- Advantage
- 58
- Tel
- +86-89586680 +86-13289823923
- 1026@dideu.com
- Country
- China
- ProdList
- 9020
- Advantage
- 58
- Tel
- 0086-13720134139
- candy@biochempartner.com
- Country
- CHINA
- ProdList
- 967
- Advantage
- 58
- Tel
- --
- Fax
- --
- kexianxun@gmail.com
- Country
- China
- ProdList
- 1039
- Advantage
- 50
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58
View Lastest Price from PHENPROCOUMON manufacturers
- Product
- 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-on 435-97-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20