PHENPROCOUMON

ChemicalBook > CAS DataBase List > PHENPROCOUMON

Product Name: PHENPROCOUMON
CAS No.: 435-97-2
Chemical Name: PHENPROCOUMON
Synonyms: MARCUMA;Fencumar;Liquamar;Marcumar;Falithrom;Falithiom;Marcoumar;RO 1-4849;Phenprocumon;PHENPROCOUMON
CBNumber: CB1295890
Molecular Formula: C18H16O3
Formula Weight: 280.32
MOL File: 435-97-2.mol

Less

PHENPROCOUMON Property

Melting point:: 179-180°
Boiling point:: 463.2±45.0 °C(Predicted)
Density: 1.261±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 4.50±1.00(Predicted)
color: White to Off-White
EPA Substance Registry System: Phenprocoumon (435-97-2)

Less

Safety

RIDADR: 2811
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 435-97-2(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: P318820
Product name: Phenprocoumon
Packaging: 100mg
Price: $95
Updated: 2021/12/16

Usbiological

Product number: 165912
Product name: Phenprocoumon
Packaging: 1g
Price: $460
Updated: 2021/12/16

TRC

Product number: P318820
Product name: Phenprocoumon
Packaging: 1g
Price: $775
Updated: 2021/12/16

TRC

Product number: P318820
Product name: Phenprocoumon
Packaging: 500mg
Price: $425
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003816
Product name: PHENPROCOUMON
Purity: 95.00%
Packaging: 1G
Price: $450
Updated: 2021/12/16

Less

PHENPROCOUMON Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Liquamar ,Organon ,US,1958

Uses

Phenprocoumon is known for being an oral anti-coagulant.

Definition

ChEBI: A hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenylpropyl group.

Manufacturing Process

8.3 parts by weight of powdered sodium in 300 parts by volume of benzene, 100 parts by weight of diethyl (1'-phenylpropyl)-malonate and 72 parts by weight of acetylsalicylic acid chloride are reacted together to form diethyl 1(o-acetoxybenzoy1)-1-(1'-phenylpropyl)malonate, which boils at 195°198°C/0.03 mm Hg.
10.3 parts of weight of diethyl 1-(o-acetoxybenzoyl)-1-(1'-phenylpropyl)malonate are dissolved in 60 parts by volume of absolute ether and to this solution are added portion. wise at 10°C, while stirring, 2.6 parts by weight of sodium methylate. The reaction mixture is stirred for 4 hours, whereupon it is poured into ice water. The ether solution is washed neutral with ice water. After having distilled off the ether, a thick oil consisting of 3-carbethoxy-3-(1'phenylpropyl)-4-oxo-dihydrocoumarinis obtained. This compound crystallized in butyl oxide and has a MP of 108°-109°C.
The 3-carbethoxy-3-(1'-phenylpropyl)-4-oxo-dihydrocoumarinmay be hydrolyzed and decarboxylated as follows. The crude product is heated to 85°C for 1/2 hour with 100 parts by volume of 5% aqueous sodium hydroxide, while agitating or stirring. To remove traces of undissolved oil, the cooled solution is treated with 1 part by weight of charcoal, whereupon it is filtrated and acidified to Congo reaction with dilute sulfuric acid. The 3-(1'phenylpropyl)-4-hydroxycoumarin formed is separated off and recrystallized in 80% ethanol, whereupon it melts at 178°-179°C according to US Patent 2,701,804.

brand name

Liquamar (Organon).

Therapeutic Function

Anticoagulant

Synthesis

Phenprocoumon, 3-(|á-ethylbenzyl)-4-hydroxycoumarin (24.1.14), is synthesized by acylating sodium salts of diethyl ester (1-phenylpropyl)butyric acid with acetylsalicylic acid chloride, which forms the compound 24.1.12, which upon reaction with sodium ethoxide cyclizes to 3-(|á-ethylbenzyl)-2-carboethoxy-4-hydroxycoumarin (24.1.13). Alkaline hydrolysis of this product and further decarboxylation gives phenprocoumon(24.1.14).

PHENPROCOUMON Preparation Products And Raw materials

Raw materials

Preparation Products

Less

PHENPROCOUMON Suppliers

Canada 1 China 53 India 2 Romania 1 United Kingdom 2 United States 20 Global 79

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3876
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6463
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Honest Joy Holdings Limited

Tel: 755-36694831 +8613798234863
Email: Linda.zhou@debayer.com
Country: China
ProdList: 998
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15354
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81145920 13259709322
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Wuhan kemike Biomedical Technology Co., Ltd

Tel: 027-87747081 18186681184
Email: 1344475572@qq.com
Country: China
ProdList: 7235
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 3991
Advantage: 58

DONBOO AMINO ACID COMPANY

Tel: +8613063595538
Email: donboo@donboo.com
Country: China
ProdList: 9363
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7973
Advantage: 58

Mainchem Co., Ltd.

Tel: --
Fax: --
Email: sarah@mainchem.com
Country: China
ProdList: 6567
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10002
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 8140
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13341702378
Email: 190129269@qq.com
Country: China
ProdList: 9126
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9951
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

WEITIXIHAUGONG

Tel: 0371-53370800 18037197114
Email: 2853031799@qq.com
Country: China
ProdList: 10007
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29794
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 15583
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 5345
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9762
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 70071
Advantage: 58

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 15092
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32957
Advantage: 60

Hangzhou FandaChem Co.,Ltd.

Tel: +8615858145714
Fax: +86-571-56059825
Email: FandaChem@Gmail.com
Country: China
ProdList: 9210
Advantage: 55

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43340
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49979
Advantage: 58

Shaanxi Didu New Materials Co. Ltd

Tel: +86-89586680 +86-13289823923
Email: 1026@dideu.com
Country: China
ProdList: 8670
Advantage: 58

Biochempartner

Tel: 0086-13720134139
Email: candy@biochempartner.com
Country: CHINA
ProdList: 965
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: --
Fax: --
Email: kexianxun@gmail.com
Country: China
ProdList: 1037
Advantage: 50

Less

View Lastest Price from PHENPROCOUMON manufacturers

Honest Joy Holdings Limited

Product: 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-on 435-97-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-02-20

435-97-2, PHENPROCOUMONRelated Search:

COUMACHLOR Bromadiolone Brodifacoum PYRANOCOUMARIN Warfarin sodium ACENOCOUMAROL (S)-(-)-WARFARIN 7-HYDROXYWARFARIN 10-HYDROXYWARFARIN 6-HYDROXYWARFARIN 8-HYDROXYWARFARIN (R)-(+)-WARFARIN 7-HYDROXYWARFARIN 4-HYDROXY-3-[1'-(4''-HYDROXYPHENYL)-3'-OXOBUTYL]-2H-1-BENZOPYRAN-2-ONE (R)-Phenprocoumon Phenprocoumon-d5 (S)-Phenprocoumon phepromaron

PHENPROCOUMON

2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-phenylpropyl)-

3-(1-Phenylpropyl)-4-hydroxycoumarin

3-(1'-Phenyl-propyl)-4-oxycoumarin

3-(alpha-Ethylbenzyl)-4-hydroxycoumarin

4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one

4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one

Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy-

Falithiom

Falithrom

Fencumar

Liquamar

Marcoumar

Marcumar

Phenprocoumarol

Phenprocoumarole

Phenprocumone

RO 1-4849

4-hydroxy-3-(1-phenylpropyl)coumarin

PHENYLPROPYL-4-HYDROXYCOUMARIN

Phenprocumon

3-(α-Ethylbenzyl)-4-hydroxycoumarin

4-Hydroxy-2-oxo-3-(1-phenylpropyl)-2H-chromene

2-hydroxy-3-[(1S)-1-phenylpropyl]-4H-chroMen-4-one

4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-on

Phenprocoumon (Marcumar)

MARCUMA

inhibit,Phenprocoumon,Inhibitor

4-Hydroxy-3-(1-phenyl propyl)-2H-1-Benzopyran Custom

435-97-2