Hydroxypioglitazone

ChemicalBook > CAS DataBase List > Hydroxypioglitazone

Product Name: Hydroxypioglitazone
CAS No.: 146062-44-4
Chemical Name: Hydroxypioglitazone
Synonyms: Leriglitazone;HYDROXYPIOGLITAZONE;Hydroxypioglitazone M4;Pioglitazone Impurity 4;Pioglitazone Impurity 18;Pioglitazone M4 Metabolite;Pioglitazone, hydroxy M-IV;Hydroxy Pioglitazone (M-IV);Hydroxy Pioglitazone Solution, 100ppm;5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE
CBNumber: CB1299313
Molecular Formula: C19H20N2O4S
Formula Weight: 372.44
MOL File: 146062-44-4.mol

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Hydroxypioglitazone Property

Melting point:: 157-1580C
Boiling point:: 627.6±55.0 °C(Predicted)
Density: 1.325±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
pka: 6.35±0.50(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 146062-44-4

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28043
Product name: Hydroxy Pioglitazone
Packaging: 1mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 28043
Product name: Hydroxy Pioglitazone
Packaging: 5mg
Price: $820
Updated: 2024/03/01

Usbiological

Product number: 293691
Product name: Hydroxy pioglitazone
Packaging: 1mg
Price: $827
Updated: 2021/12/16

Usbiological

Product number: 293692
Product name: Hydroxy pioglitazone
Packaging: 1mg
Price: $891
Updated: 2021/12/16

TRC

Product number: H952075
Product name: HydroxyPioglitazone(M-IV)
Packaging: 10mg
Price: $1450
Updated: 2021/12/16

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Hydroxypioglitazone Chemical Properties,Usage,Production

Description

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (K_i = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC₅₀ = 2.1 μM).

Chemical Properties

Off-White Solid

Uses

A metabolite of Pioglitazone (P471000).

Definition

ChEBI: Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It is functionally related to a pioglitazone.

Hydroxypioglitazone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Hydroxypioglitazone manufacturers

Career Henan Chemical Co

Product: Hydroxypioglitazone 146062-44-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

146062-44-4, HydroxypioglitazoneRelated Search:

Pioglitazone 4'-Hydroxyacetophenone Pioglitazone Troglitazone Gliquidone Pioglitazone hydrochloride a-[(Aminocarbonyl)thio]-4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzenepropanoic Acid Ethyl Ester Pioglitazone Aldehyde Impurity 5-(4-Fluorobenzyl)-2,4-thiazolidinedione 4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyaldehyde Hydroxy Pioglitazone (M-II) (Mixture of Diastereomers) Pioglitazone Sulfonic Acid IMpurity 2-[2-(4-BroMophenoxy)ethyl]-5-ethylpyridine Pioglitazone Impurity 5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone Pioglitazone N-Oxide 5-(4-Hydroxybenzyl)-2,4-thiazolidinedione 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE

HYDROXYPIOGLITAZONE

Hydroxy Pioglitazone (M-IV)

5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE

Pioglitazone, hydroxy M-IV

Pioglitazone Impurity 18

Hydroxy Pioglitazone Solution, 100ppm

Pioglitazone M4 Metabolite

Leriglitazone

Pioglitazone Impurity 4

2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-

Hydroxypioglitazone M4

146062-44-4

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Various Metabolites and Impurities

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