4-BROMOISATIN
Application- Product Name
- 4-BROMOISATIN
- CAS No.
- 20780-72-7
- Chemical Name
- 4-BROMOISATIN
- Synonyms
- 4-BROM;4-Broisatin;4-BROMOISATIN;4-Bromoisatin 98%;BUTTPARK 50\07-93;4-Bromoisatin >4- broMoindigo carMine;Fampridine Impurity 25;4-BROMOINDOLE-2,3-DIONE;4-BROMOINDOLINE-2,3-DIONE
- CBNumber
- CB1301591
- Molecular Formula
- C8H4BrNO2
- Formula Weight
- 226.03
- MOL File
- 20780-72-7.mol
4-BROMOISATIN Property
- Melting point:
- 253-256
- Density
- 1.826±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Dimethylformamide
- form
- powder to crystal
- pka
- 8.73±0.20(Predicted)
- color
- Light yellow to Brown
- InChI
- InChI=1S/C8H4BrNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12)
- InChIKey
- ITRAKBJPMLKWIW-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC=C2)C(=O)C1=O
- CAS DataBase Reference
- 20780-72-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B2423
- Product name
- 4-Bromoisatin
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- B2423
- Product name
- 4-Bromoisatin
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $116
- Updated
- 2025/07/31
- Product number
- B685523
- Product name
- 4-Bromoisatin
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR3606
- Product name
- 4-Bromoisatin
- Purity
- 98%
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H48-9-Y6
- Product name
- 4-Bromoisatin
- Purity
- 98%
- Packaging
- 5G
- Price
- $16
- Updated
- 2021/12/16
4-BROMOISATIN Chemical Properties,Usage,Production
Application
4-Bromoindigo is an organic bromide that can be used as an intermediate in pharmaceutical synthesis.
Definition
ChEBI: 4-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent.
Synthesis
65971-74-6
6326-79-0
20780-72-7
The general procedure for the synthesis of 6-bromodihydroindole-2,3-diones and 4-bromoindoline-2,3-diones using 2-hydroxyimino-N-(3-bromophenyl)-acetamide as starting material is as follows: 1. to a solution of hydrogen chloride (50.0 g, 0.247 mol) in water (237 mL) was sequentially added a mixture of anhydrous sodium sulfate (69.0 g, 0.486 mol) and 3-bromoaniline (40.0 g, 0.233 mol) in 37% hydrochloric acid (25 mL). 2. Water (632 mL) was added slowly with vigorous stirring. After addition, the reaction mixture was heated to reflux for 10 minutes and then cooled to room temperature. 3. The precipitate formed was collected by filtration, washed with water (3 x 100 mL) and dried under vacuum to give crude isonitrosoacetanilide. 4. The crude product was added in batches to rapidly stirred concentrated sulfuric acid (790 mL), with the rate of addition controlled to maintain the reaction temperature between 50 and 70 °C. The reaction was carried out in a controlled manner. 5. The reaction mixture was heated to 80°C, held for 20 minutes, and then cooled to room temperature. 6. The cooled mixture was poured into crushed ice (about 320 g) and allowed to stand for 1 hour. 7. The orange precipitate was collected by filtration, washed with water and dried to give a mixture of 4-bromoindigo (K-98) and 6-bromoindigo (K-99) (40 g, 83% yield).
References
[1] Patent: WO2006/44415, 2006, A2. Location in patent: Page/Page column 118
[2] Synthetic Communications, 2010, vol. 40, # 21, p. 3125 - 3134
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 935 - 946
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4641 - 4649
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 18 - 36
4-BROMOISATIN Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMOISATIN Suppliers
- Tel
- --
- Fax
- --
- enamine@enamine.net
- Country
- Ukraine
- ProdList
- 6216
- Advantage
- 67
View Lastest Price from 4-BROMOISATIN manufacturers
- Product
- 4-Bromoisatin 20780-72-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-16
- Product
- 4-BROMOISATIN 20780-72-7
- Price
- US $36.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 4-BROMOISATIN 20780-72-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11