7-BROMO-1H-INDOLE-2,3-DIONE
- Product Name
- 7-BROMO-1H-INDOLE-2,3-DIONE
- CAS No.
- 20780-74-9
- Chemical Name
- 7-BROMO-1H-INDOLE-2,3-DIONE
- Synonyms
- 7-BROMOINDOLINE-2,3-DIONE;7-BROMO-ISATIN;BUTTPARK 50\07-96;7-Bromoisatin 97%;7-Bromoisatin >7-Bromoisatin,>97%;7-Bromoindole-2,3-dione;7-BROMO-2,3-DIOXOINDOLINE;7-Bromo-2,3-indolinedione;7-Bromoindole-1H-2,3-dione
- CBNumber
- CB3765683
- Molecular Formula
- C8H4BrNO2
- Formula Weight
- 226.03
- MOL File
- 20780-74-9.mol
7-BROMO-1H-INDOLE-2,3-DIONE Property
- Melting point:
- 191-198 °C
- Density
- 1.826±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Slightly soluble.
- form
- powder to crystal
- pka
- 8.69±0.20(Predicted)
- color
- Orange to Amber to Dark red
- InChI
- InChI=1S/C8H4BrNO2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11/h1-3H,(H,10,11,12)
- InChIKey
- OCVKSIWBTJCXPV-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2Br)C(=O)C1=O
- CAS DataBase Reference
- 20780-74-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 679127
- Product name
- 7-Bromoisatin
- Purity
- 96%
- Packaging
- 1g
- Price
- $55.95
- Updated
- 2025/07/31
- Product number
- B3974
- Product name
- 7-Bromoisatin
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- B3974
- Product name
- 7-Bromoisatin
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- B688753
- Product name
- 7-Bromo-1H-indole-2,3-dione
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B688753
- Product name
- 7-Bromo-1H-indole-2,3-dione
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
7-BROMO-1H-INDOLE-2,3-DIONE Chemical Properties,Usage,Production
Uses
7-bromoisatin was treated with excess PhMgBr to afford tertiary alcohol 9 in 96 % yield. Isatin oxime triflates undergo a facile fragmentation which is promoted by DBU, to form anthranilonitriles after hydrolytic work-up.
Synthesis
101080-38-0
20780-74-9
Step 2: N-(2-bromophenyl)-2-(hydroxyimino)acetamide (7 g, 0.028 mol) was slowly added to 70 mL of concentrated sulfuric acid, and the temperature of the reaction system was maintained at 60 °C. Subsequently, the reaction temperature was raised to 90 °C with continuous stirring for 3 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and a yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 7-bromoisatin as a yellow solid (6.0 g, 92% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 11.33 (s, 1H), 7.79 (d, J = 8.1 Hz, 1H), 7.52 (d, J = 7.2 Hz, 1H), 7.02 (t, J = 7.5 Hz, 1H); LC-MS (ESI) analysis: calculated mass: 224.9; observed mass: 226.0 [M + H]+ (retention time: 0.39 min).
References
[1] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 106
[2] Patent: CN105732462, 2016, A. Location in patent: Paragraph 0026
[3] Patent: CN103864779, 2016, B. Location in patent: Paragraph 0066; 0067; 0069
[4] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 38
[5] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 1, p. 22 - 26
7-BROMO-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-BROMO-1H-INDOLE-2,3-DIONE manufacturers
- Product
- 7-BROMO-1H-INDOLE-2,3-DIONE 20780-74-9
- Price
- US $36.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-20
- Product
- 7-BROMO-1H-INDOLE-2,3-DIONE 20780-74-9
- Price
- US $36.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 7-Bromoisatin 20780-74-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10