L-Valine benzyl ester hydrochloride

Product Name: L-Valine benzyl ester hydrochloride
CAS No.: 2462-34-2
Chemical Name: L-Valine benzyl ester hydrochloride
Synonyms: Val-OBzl.HCl;H-VAL-OBZL HCL;H-Val-OBzl.HCI;L-Val-OBzl·HCl;VALINE-OBZL HCL;H-L-Val-Obzl.HCl;L-Valine benzyl ester, HCl;Benzyl L-Valinate Hydrochloride;Valine Benzyl Ester Hydrochloride;L-VALINE BENZYL ESTER HYDROCHLORIDE
CBNumber: CB1302543
Molecular Formula: C12H18ClNO2
Formula Weight: 243.73
MOL File: 2462-34-2.mol

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L-Valine benzyl ester hydrochloride Property

Melting point:: 138 °C
refractive index: -10 ° (C=2, H2O)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform, Methanol, Water
form: Solid
color: White
optical activity: Consistent with structure
CAS DataBase Reference: 2462-34-2(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: V0078
Product name: L-Valine Benzyl Ester Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $29
Updated: 2025/07/31

TRC

Product number: V094271
Product name: L-Valine benzyl ester hydrochloride
Packaging: 5G
Price: $90
Updated: 2021/12/16

Usbiological

Product number: 291991
Product name: L-Valine benzyl ester hydrochloride
Packaging: 5g
Price: $333
Updated: 2021/12/16

Usbiological

Product number: 022700
Product name: L-Valine Benzyl Ester Hydrochloride
Packaging: 10g
Price: $418
Updated: 2021/12/16

Oakwood

Product number: 222171
Product name: L-Valine benzyl ester hydrochloride
Packaging: 1g
Price: $15
Updated: 2021/12/16

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L-Valine benzyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Valine Benzyl Ester is a L-Valine derivative useful as intermediate for the preparation of peptides.

Uses

L-Valine benzyl ester hydrochloride is a L-Valine derivative useful as intermediate for the preparation of peptides.

Synthesis

72-18-4

100-51-6

2462-34-2

The general procedure for the synthesis of (S)-benzyl (S)-2-amino-3-methylbutyrate hydrochloride from L-valine and benzyl alcohol was as follows: 11.5 g (0.1 mol) of L-valine, 30 mL of ethylene dichloride, and 16.2 g (0.1 mol) of FeCl3 were added to a 250 mL three-neck flask. Hydrogen chloride gas was passed at a rate of 1.25 mL/s and the reaction was carried out for 0.5 h at room temperature. A total of 2250 mL (0.1 mol) of HCl was passed. subsequently, 11.66 g (0.108 mol) of benzyl alcohol (molar ratio of L-valine to benzyl alcohol 1:1.08) was added and the reaction was continued by passing HCl at a rate of 0.05 mL/s for 3 h. The reaction was carried out under reflux conditions. The aqueous dichloroethane solution was removed by azeotropic distillation under reflux conditions while anhydrous dichloroethane was replenished at the same rate to maintain the reaction volume. A total of 120 mL of the azeotrope was distilled and passed through 540 mL (0.024 mol) HCl. Upon completion of the reaction, the reaction solution was filtered while still hot to remove the catalyst FeCl3, and the filtrate was recycled. The filtrate was cooled to room temperature and the remaining dichloroethane was removed by vacuum distillation (10 mmHg, 40°C). The product was recrystallized at -10°C and the resulting solid was washed with 20 mL of pre-cooled dichloroethane (0°C), filtered and the filter cake was dried at 40°C for 5 h to give 18.20 g of (S)-benzyl (S)-2-amino-3-methylbutanoate hydrochloride in 75.3% yield. The 120 mL mixture obtained by azeotropic distillation was dehydrated with anhydrous sodium sulfate (5 g of anhydrous sodium sulfate per 100 mL of dichloromethane) to obtain 118 mL of anhydrous dichloroethane, which was available for recycling in Step 2. The retained filtrate was concentrated to 20 mL by rotary evaporation (10 mmHg, 40°C) and used as the mother liquor for the next batch of the reaction.

References

[1] Patent: CN105061283, 2017, B. Location in patent: Paragraph 0047-0049
[2] Journal of the Chinese Chemical Society, 2009, vol. 56, # 5, p. 1010 - 1017
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6220 - 6229
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011, vol. 50, # 9, p. 1157 - 1164

L-Valine benzyl ester hydrochloride Preparation Products And Raw materials

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View Lastest Price from L-Valine benzyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Val-Obzl.HCl 2462-34-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-02

Hangzhou ICH Biofarm Co., Ltd

Product: L-Valine benzyl ester hydrochloride 2462-34-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%min
Supply Ability: 10tons
Release date: 2023-07-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-Valine benzyl ester hydrochloride 2462-34-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

2462-34-2, L-Valine benzyl ester hydrochlorideRelated Search:

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L-VALINE BENZYL ESTER HYDROCHLORIDE

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VALINE-OBZL HCL

H-Val-OBzl.HCI

H-Val-OBzl HCl (L-Valine benzyl ester hydrochloride)

Val-OBzl.HCl

(S)-Benzyl 2-aMino-3-Methylbutanoate hydrochloride

Benzyl L-Valinate Hydrochloride

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Valine Benzyl Ester Hydrochloride

benzyl (2S)-2-aMino-3-Methylbutanoate hydrochloride

(2S)-1-(Benzyloxy)-3-Methyl-1-oxo-2-butanaMiniuM chloride

L-Valine Benzyl Ester Hydrochloride , 98.0%(LC&N

L-Valine benzyl ester hydrochloride, >=99%

L-VALINE BETHYL ESTER HYDROCHLORIDE

L-Val-OBzl·HCl

<small>L</small>-Valine Benzyl Ester Hydrochloride

L-Valine, phenylmethyl ester, hydrochloride (1:1)

L-Valine benzyl ester hydrochloride≥ 99.9% (HPLC)

L-Valine benzyl ester, HCl

L-Valine benzyl ester hydrochloride USP/EP/BP

L-Valine Benzyl Ester Hydrochloride extrapure, 98%

H-L-Val-Obzl.HCl

L-Valinebenzyl ester hydrochloride, 95%

2462-34-2

246-34-2

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