COELENTERAZINE H
- Product Name
- COELENTERAZINE H
- CAS No.
- 50909-86-9
- Chemical Name
- COELENTERAZINE H
- Synonyms
- COEL;CLZ-H;CLZN-H;ENTERAZINE H;Colenterazine H;COELENTERAZINE H;H-coelenterazine;Renilla Luciferin;LUCIFERIN (RENILLA);2-DEOXYCOELENTERAZINE
- CBNumber
- CB1304820
- Molecular Formula
- C26H21N3O2
- Formula Weight
- 407.46
- MOL File
- 50909-86-9.mol
COELENTERAZINE H Property
- Melting point:
- >200℃
- Boiling point:
- 593.5±60.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in methanol, ethanol
- pka
- 10.50±0.30(Predicted)
- form
- solid
- color
- Yellow
- Appearance
- Yellow Solid
- λmax
- 437nm
- Stability:
- Stable for 1 year from ate of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
- Biological Applications
- Calcium indicator; assaying luminescent enzyme; measuring luciferase activity; as a substrate for luciferase; screening HIV-1 protease inhibitors; bioluminescence resonance energy transfer (BRET) detection system
- InChI
- InChI=1S/C26H21N3O2/c30-21-13-11-20(12-14-21)24-17-29-25(22(27-24)15-18-7-3-1-4-8-18)28-23(26(29)31)16-19-9-5-2-6-10-19/h1-14,17,27,30H,15-16H2
- InChIKey
- KAEGGIFPLJZUOZ-UHFFFAOYSA-N
- SMILES
- C12N=C(CC3=CC=CC=C3)C(=O)N1C=C(C1=CC=C(O)C=C1)NC=2CC1=CC=CC=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C3230
- Product name
- Coelenterazine h
- Purity
- solid
- Packaging
- 50μg
- Price
- $209
- Updated
- 2025/07/31
- Product number
- 16894
- Product name
- Coelenterazine h
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 16894
- Product name
- Coelenterazine h
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $345
- Updated
- 2024/03/01
- Product number
- C636025
- Product name
- Coelenterazine h
- Packaging
- 1mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- CHM0007260
- Product name
- COELENTERAZINE H
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.66
- Updated
- 2021/12/16
COELENTERAZINE H Chemical Properties,Usage,Production
Description
Coelenterazine-h (50909-86-9) may be used as a substrate in gene reporter assays, live cell assays, and biochemical assays (ELISA, BRET etc). Renilla luciferase catalyzes coelenterazine oxidation by oxygen to produce light. Coelenterazine-h produces 10-fold higher light output than native coelenterazine. Coelenterazine-h also undergoes autoluminescence, which is enhanced by superoxide anion and peroxynitrite in cells.
Uses
Coelenterazine h, is a derivative of Coelenterazine (C636000), and iis more sensitive to Ca2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca2+ concentrations.
Definition
ChEBI: Renilla luciferin is a member of phenols and an imidazopyrazine. It has a role as a luciferin. It derives from a hydride of an imidazo[1,2-a]pyrazine.
General Description
Coelenterazine is an imidazopyrazinone derivative. It is a substrate for bioluminescence in many luminous marine organisms.
Biochem/physiol Actions
10 times higher luminescence intensity than native coelenterazine.
References
[1] O SHIMOMURA Y K B Musicki. Semi-synthetic aequorins with improved sensitivity to Ca2+ ions.[J]. Biochemical Journal, 1989, 261 3: 913-920. DOI:10.1042/bj2610913
[2] J NAKAJIMA-SHIMADA. Monitoring of intracellular calcium in Saccharomyces cerevisiae with an apoaequorin cDNA expression system.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88 15: 6878-6882. DOI:10.1073/pnas.88.15.6878
[3] SATOSHI INOUYE Frederick I T. Monitoring gene expression in Chinese hamster ovary cells using secreted apoaequorin[J]. Analytical biochemistry, 1992, 201 1: Pages 114-118. DOI:10.1016/0003-2697(92)90182-7
COELENTERAZINE H Preparation Products And Raw materials
Raw materials
Preparation Products
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