COELENTERAZINE H

ChemicalBook > CAS DataBase List > COELENTERAZINE H

Product Name: COELENTERAZINE H
CAS No.: 50909-86-9
Chemical Name: COELENTERAZINE H
Synonyms: COEL;CLZ-H;CLZN-H;ENTERAZINE H;Colenterazine H;COELENTERAZINE H;H-coelenterazine;Renilla Luciferin;LUCIFERIN (RENILLA);2-DEOXYCOELENTERAZINE
CBNumber: CB1304820
Molecular Formula: C26H21N3O2
Formula Weight: 407.46
MOL File: 50909-86-9.mol

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COELENTERAZINE H Property

Melting point:: >200℃
Boiling point:: 593.5±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in methanol, ethanol
pka: 10.50±0.30(Predicted)
form: solid
color: Yellow
λmax: 437nm
Stability:: Stable for 1 year from ate of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Biological Applications: Calcium indicator; assaying luminescent enzyme; measuring luciferase activity; as a substrate for luciferase; screening HIV-1 protease inhibitors; bioluminescence resonance energy transfer (BRET) detection system

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C3230
Product name: Coelenterazine h
Purity: solid
Packaging: 50μg
Price: $203
Updated: 2024/03/01

Cayman Chemical

Product number: 16894
Product name: Coelenterazine h
Purity: ≥95%
Packaging: 500μg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 16894
Product name: Coelenterazine h
Purity: ≥95%
Packaging: 1mg
Price: $345
Updated: 2024/03/01

TRC

Product number: C636025
Product name: Coelenterazine h
Packaging: 1mg
Price: $285
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0007260
Product name: COELENTERAZINE H
Purity: 95.00%
Packaging: 5MG
Price: $496.66
Updated: 2021/12/16

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COELENTERAZINE H Chemical Properties,Usage,Production

Description

Coelenterazine-h (50909-86-9) may be used as a substrate in gene reporter assays, live cell assays, and biochemical assays (ELISA, BRET etc). Renilla luciferase catalyzes coelenterazine oxidation by oxygen to produce light. Coelenterazine-h produces 10-fold higher light output than native coelenterazine. Coelenterazine-h also undergoes autoluminescence, which is enhanced by superoxide anion and peroxynitrite in cells.

Uses

Coelenterazine h, is a derivative of Coelenterazine (C636000), and iis more sensitive to Ca2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca2+ concentrations.

Definition

ChEBI: Renilla luciferin is a member of phenols and an imidazopyrazine. It has a role as a luciferin. It derives from a hydride of an imidazo[1,2-a]pyrazine.

General Description

Coelenterazine is an imidazopyrazinone derivative. It is a substrate for bioluminescence in many luminous marine organisms.

Biochem/physiol Actions

10 times higher luminescence intensity than native coelenterazine.

References

1) Shimomura?et al. (1989),?Semi-synthetic aequorins with improved sensitivity to Ca2+ ions; Biochem. J.,?261?913 2) Nakajima-Shimada?et al.?(1991),?Monitoring of intracellular calcium in Saccharomyces cerevisiae with an apoaequorin cDNA expression system; Proc. Natl. Acad. Sci. USA,?88?6878 3) Inouye?et al. (1992),?Monitoring gene expression in Chinese hamster ovary cells using secreted apoaequorin; Anal. Biochem.,?201?114

COELENTERAZINE H Preparation Products And Raw materials

Raw materials

Preparation Products

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50909-86-9, COELENTERAZINE HRelated Search:

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Renilla Luciferin

H-coelenterazine

2-Deoxycoelenterazine Luciferin (Renilla)

Colenterazine H

2,8-dibenzyl-6-(4-hydroxyphenyl)iMidazo[1,2-a]pyrazin-3(7H)-one

CLZN h [Coelenterazine h]

CLZ-H

CLZN-H

COELENTERAZINE H

COELENTERAZINE-H, SYNTHETIC

LUCIFERIN (RENILLA)

2-(4-DEHYDROXY)COELENTERAZINE

2,8-DIBENZYL-6-(P-HYDROXYPHENYL)-IMIDAZO[1,2A]PYRAZIN-3-(7H)-ONE

2-BENZYL-6-(P-HYDROXYPHENYL)-8-BENZYLIMIDAZO[1,2-A]PYRAZIN-3-(7H)-ONE

2-DEOXYCOELENTERAZINE

2,8-dibenzyl-6-(4-hydroxyphenyl)imidazo[1,20-a]pyrazin-3(7H)one

Coelenterazine.UltraPure grade.

COEL

ENTERAZINE H

Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2,8-bis(phenylmethyl)-

Coelenterazine h solid

2,8-dibenzyl-6-(4-hydroxyphenyl)-7H-imidazo[1,2-a]pyrazin-3-one

Inhibitor,Coelenterazine h,inhibit

50909-86-9

C26H21N3O2

Coelenterazine Derivatives

Luminescent

Intracellular Calcium Signaling

BioChemical

Cell Signaling and Neuroscience

Calcium Probes

Calcium Signaling Research Tools

Cell Biology

Heterocycle

Imidazo[1,2-a]pyrazin-3(7H)-one