ROR gamma-t-IN-1

Product Name: ROR gamma-t-IN-1
CAS No.: 1426802-50-7
Chemical Name: ROR gamma-t-IN-1
Synonyms: GSK805;ROR gamma-t-IN-1;GSK805 (GSK-805);GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-;4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one;N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide;N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide;Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-;N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CBNumber: CB13048666
Molecular Formula: C23H18Cl2F3NO4S
Formula Weight: 532.36
MOL File: 1426802-50-7.mol

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ROR gamma-t-IN-1 Property

Boiling point:: 617.1±55.0 °C(Predicted)
Density: 1.434±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM)
form: A crystalline solid
pka: 12.33±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 9002444
Product name: GSK805
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 9002444
Product name: GSK805
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 9002444
Product name: GSK805
Purity: ≥98%
Packaging: 10mg
Price: $235
Updated: 2024/03/01

ChemScene

Product number: CS-5079
Product name: GSK805
Purity: 97.14%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

AK Scientific

Product number: 2948DU
Product name: RORgamma-t-IN-1
Packaging: 10mg
Price: $360
Updated: 2021/12/16

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ROR gamma-t-IN-1 Chemical Properties,Usage,Production

Description

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4⁺ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.

ROR gamma-t-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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ROR gamma-t-IN-1 Suppliers

China 47 United States 6 Global 53

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
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Email: market@dingdangchem.com
Country: China
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Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Email: info@chemexpress.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

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Struchem Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Fax: 21-5161 9052
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Shanghai SuperLan Chemcial Technique Centre

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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
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Amadis Chemical Company Limited

Tel: 571-89925085
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1426802-50-7, ROR gamma-t-IN-1Related Search:

GSK8612 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone GSK8612 GSK6853 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid GSK620 GSK591 GSK5959 GSK872

ROR gamma-t-IN-1

GSK805

GSK805 (GSK-805)

N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one

Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-

N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide

N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide

GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-

N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

GSK 805,immunity,RAR-related orphan receptor,Inhibitor,GSK805,inhibit,ROR,oral,CNS penetrant,GSK-805,Th17 cell

N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

1426802-50-7

C23H18Cl2F3NO4S