DCEBIO Property

Melting point:

205-207 °C(Solv: ethyl acetate (141-78-6))

Density 

1.412±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

DMSO: >10mg/mL

form 

solid

pka

10.28±0.30(Predicted)

color 

off-white

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DCEBIO Chemical Properties,Usage,Production

Description

DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance. 

Uses

DCEBIO is a small Ca2+sensitive K+ channel (SKCa) agonist. It also stimulate nitric oxide (NO) synthesis and vasodilation in resistance arteries.

Definition

ChEBI: DCEBIO is a dichlorobenzene.

Biological Activity

Stimulates Cl - secretion via activation of hIK1 K + channels and the activation of an apical Cl - conductance. More potent than its analog 1-EBIO (1-Ethyl-2-benzimidazolinone ).

storage

Store at RT