ChemicalBook > CAS DataBase List > 1-Cyclohexylpiperazine

1-Cyclohexylpiperazine

Product Name
1-Cyclohexylpiperazine
CAS No.
17766-28-8
Chemical Name
1-Cyclohexylpiperazine
Synonyms
AKOS BBS-00003612;BUTTPARK 82\06-06;TIMTEC-BB SBB003875;Avatopal impurity 47;N-Cyclohexylpiperazine;1-Cyclohexylpiperizine;1-CYCLOHEXYLPIPERAZINE;Avatrombopag Impurity 9;Piperazine, 1-cyclohexyl-;Avatroposide impurities15
CBNumber
CB1309032
Molecular Formula
C10H20N2
Formula Weight
168.28
MOL File
17766-28-8.mol
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1-Cyclohexylpiperazine Property

Melting point:
28-32 °C
Boiling point:
287.25°C (rough estimate)
Density 
0.9725 (rough estimate)
refractive index 
1.6011
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Low Melting Solid
pka
9.25±0.10(Predicted)
color 
Yellow-brownish
BRN 
106845
InChI
InChI=1S/C10H20N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h10-11H,1-9H2
InChIKey
XPDSXKIDJNKIQY-UHFFFAOYSA-N
SMILES
N1(C2CCCCC2)CCNCC1
CAS DataBase Reference
17766-28-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-26
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C1783
Product name
1-Cyclohexylpiperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
C1783
Product name
1-Cyclohexylpiperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$126
Updated
2025/07/31
TRC
Product number
C988102
Product name
1-Cyclohexylpiperazine
Packaging
500mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
409578
Product name
1-Cyclohexylpiperazine
Packaging
500mg
Price
$319
Updated
2021/12/16
AK Scientific
Product number
J90395
Product name
1-Cyclohexylpiperazine
Packaging
1g
Price
$12
Updated
2021/12/16
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1-Cyclohexylpiperazine Chemical Properties,Usage,Production

Chemical Properties

yellow-brownish low melting solid

Uses

1-Cyclohexylpiperazine is an σ1 and σ2 receptor ligands with diagnostic and therapeutic potentials.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7331, 1994 DOI: 10.1016/0040-4039(94)85306-1

Materials Uses

1-Cyclohexylpiperazine can be used to develop new luminescent materials such as [CYP]ZnBr4 (CYP = 1-cyclohexylpiperazine). It is a highly efficient blue luminescent lead-free halide material with high luminous efficiency (photoluminescence quantum yield up to 79.22%) and stability, which can be used to manufacture highly efficient blue phosphors for white light-emitting diodes (LEDs) [1].

Synthesis

1224935-95-8

17766-28-8

General procedure for the synthesis of 1-cyclohexylpiperazine from tert-butyl 4-cyclohexylpiperazine-1-carboxylate: tert-butyl 4-cyclohexylpiperazine-1-carboxylate (1.38 g, 5.15 mmol) was dissolved in a mixture of ethanol/hydrochloric acid (15 mL), and the reaction was stirred for 18 h at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, 5 mL of water was added and the aqueous phase was washed with ethyl acetate (5 mL × 3). Subsequently, the aqueous phase was adjusted to pH 7~8 with base and extracted with ethyl acetate (10 mL × 3). All organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 0.78 g of 1-cyclohexylpiperazine (confirmed by LC-MS and TLC, yield: 90.1%).

References

[1] Wang, Yu-Yin et al. “High Emission Efficiency and Thermal Stability in Zero-Dimensional Hybrid Zinc Halide as a Blue Light Emitter.” Inorganic chemistry vol. 62,38 (2023): 15711-15718. doi:10.1021/acs.inorgchem.3c02313

1-Cyclohexylpiperazine Preparation Products And Raw materials

Raw materials

Bromocyclohexane Acetonitrile Ethanol Potassium iodide Potassium carbonate Piperazine Dichloromethane Sodium hydroxide

Preparation Products

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View Lastest Price from 1-Cyclohexylpiperazine manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.
Product
1-Cyclohexylpiperazine 17766-28-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
＞99% by GC
Supply Ability
50kg
Release date
2023-01-05
R&D Scientific Inc.
Product
1-Cyclohexylpiperazine 17766-28-8
Price
US $2900.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-05-08
Jinan Ande Pharmaceutical Co.,Ltd.
Product
1-Cyclohexylpiperazine 17766-28-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100
Release date
2021-12-18

17766-28-8, 1-CyclohexylpiperazineRelated Search:

Allyl cyclohexylpropionate Isocyanatocyclohexane Cyclohexanecarboxylic acid Cyclohexanecarboxaldehyde Molasses 1-Ethynyl-1-cyclohexanol trans-1-Cinnamylpiperazine Pipecuronium bromide 1-(4-METHYL-CYCLOHEXYL)-PIPERAZINE 3-(4-CYCLOHEXYL-PIPERAZIN-1-YL)-PROPIONIC ACID (R)-1-CYCLOHEXYL-3-METHYL-PIPERAZINE 1-(1-Piperazinyl)adamantane dihydrochloride AKOS B017837 Piperazine, 1-(3-methylcyclohexyl)- (6CI) 1-(2-METHYL-CYCLOHEXYL)-PIPERAZINE 1-(1-ADAMANTYL)PIPERAZINE 4-CYCLOHEXYLPIPERAZINE-1-CARBOXIMIDAMIDE HYDROIODIDE N-cyclohexylpiperazine-1-carboxamide hydrochloride

  • N-Cyclohexylpiperazine
  • BUTTPARK 82\06-06
  • 1-CYCLOHEXYL-PIPERAZINE >98%
  • 1-CYCLOHEXYLPIPERAZINE 98%
  • 1-Cyclohexylpiperizine
  • Piperazine, 1-cyclohexyl-
  • AKOS BBS-00003612
  • 1-Cyclohexylpiperazine ,97%
  • 1-Cyclohexylpiperazine, 98% 25GR
  • (Piperazin-1-yl)cyclohexane
  • N-Cyclohexyl piperazine 1-Cyclohexylpiperazine
  • TIMTEC-BB SBB003875
  • 1-CYCLOHEXYLPIPERAZINE
  • 1-Cyclohexylpiperazine &gt
  • Avatrombopag Impurity 9
  • 1-Cyclohexylpiperazine ISO 9001：2015 REACH
  • Avatroposide impurities15
  • Avatopal impurity 47
  • 17766-28-8
  • 1766-28-8
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