GUANETHIDINE HEMISULFATE Property

Melting point:

255-265°C

Density 

1.1052 (rough estimate)

refractive index 

1.7400 (estimate)

storage temp. 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White

Merck 

4560

Stability:

Hygroscopic

CAS DataBase Reference

60-02-6

Safety

Safety Statements 

24/25

RTECS 

MF3240000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

GUANETHIDINE HEMISULFATE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Ismelin,Ciba,US,1960

Uses

Antihypertensive; antiglaucoma

Definition

ChEBI: A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.

Manufacturing Process

13.6 grams of chloroacetyl guanide is added while stirring to a solution of 22.6 grams of heptamethylene imine in 200 ml of benzene. After warming for 1 hour, and then cooling, the solution is filtered and the filtrate concentrated under reduced pressure. The residue, containing the 2-(1-N,N-heptamethylene-imino)-aceticacid guanide, is suspended in tetrahydrofuran and added to a refluxing solution of 6 grams of lithium aluminum hydride in tetrahydrofuran. After completion of the reaction, the excess of lithium aluminum hydride is decomposed by adding water, then aqueous sodium hydroxide. The solid material is filtered off, the filtrate is acidified with sulfuric acid and the 2-(1-N,N-heptamethylene-imino)-ethyl-guanidine sulfate can be recovered and recrystallized from aqueous ethanol, MP 276° to 281°C (with decomposition).

Therapeutic Function

Antihypertensive