m-PEG11-acid

Product Name: m-PEG11-acid
CAS No.: 2280998-74-3
Chemical Name: m-PEG11-acid
Synonyms: m-PEG11-acid;mPEG10-CH2CH2COOH/2,5,8,11,14,17,20,23,26,29,32-undecaoxapentatriacontan-35-oic acid;3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
CBNumber: CB13162997
Molecular Formula: C24H48O13
Formula Weight: 544.64
MOL File: 2280998-74-3.mol

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m-PEG11-acid Property

Boiling point:: 599.1±50.0 °C(Predicted)
Density: 1.113±0.06 g/cm3(Predicted)
solubility: DMSO : 100 mg/mL (183.61 mM; Need ultrasonic)
form: Liquid
pka: 4.28±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22093
Product name: m-PEG11-acid
Purity: 98%
Packaging: 1g
Price: $480
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1550
Product name: m-PEG11-acid
Packaging: 500mg
Price: $832
Updated: 2021/12/16

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m-PEG11-acid Chemical Properties,Usage,Production

Description

m-PEG11-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

M-PEG11-acid is a non-cleavable ADC linker containing 11-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). m-PEG11-acid is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs	Non-cleavable

m-PEG11-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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m-PEG11-acid Suppliers

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View Lastest Price from m-PEG11-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: m-PEG11-COOH 2280998-74-3
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-27

2280998-74-3, m-PEG11-acidRelated Search:

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m-PEG11-acid

mPEG10-CH2CH2COOH/2,5,8,11,14,17,20,23,26,29,32-undecaoxapentatriacontan-35-oic acid

3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

2280998-74-3

C24H48O13