Triethylene Glycol 2-Bromoethyl Methyl Ether
- Product Name
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- CAS No.
- 110429-45-3
- Chemical Name
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- Synonyms
- mPEG4-Br;m-PEG4-bromo;m-PEG4-bromide;Br-(CH2CH2O)4-Me;Bromo-PEG4-methoxy;Methyl-PEG4-bromide;1-Bromo-3,6,9,12-tetraoxatridecane;13-Bromo-2,5,8,11-tetraoxatridecane;2,5,8,11-Tetraoxatridecane, 13-bromo-;Triethylene Glycol 2-Bromoethyl Methyl Ether
- CBNumber
- CB12469761
- Molecular Formula
- C9H19BrO4
- Formula Weight
- 271.15
- MOL File
- 110429-45-3.mol
Triethylene Glycol 2-Bromoethyl Methyl Ether Property
- Boiling point:
- 296.3±25.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- refractive index
- 1.4620 to 1.4660
- storage temp.
- 2-8°C
- form
- clear liquid
- color
- White to Yellow to Green
- CAS DataBase Reference
- 110429-45-3
Safety
- HS Code
- 2909.19.6000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T2634
- Product name
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $198
- Updated
- 2024/03/01
- Product number
- T2634
- Product name
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $588
- Updated
- 2024/03/01
- Product number
- T776665
- Product name
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T776665
- Product name
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 41710
- Product name
- Triethyleneglycol2-bromoethylmethylether,95%(GC)
- Purity
- 95%(GC)
- Packaging
- 5G
- Price
- $230.72
- Updated
- 2021/12/16
Triethylene Glycol 2-Bromoethyl Methyl Ether Chemical Properties,Usage,Production
Description
m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological Activity
Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|