1-Methylimidazole
- Product Name
- 1-Methylimidazole
- CAS No.
- 616-47-7
- Chemical Name
- 1-Methylimidazole
- Synonyms
- N-METHYLIMIDAZOLE;1-methyl-1h-imidazole;MIM;MeIm;methyl imidazole;1H-Imidazole, 1-methyl-;N-methylimidazole (1-methylimidazole);1-methylmidazole;N-methyl midazole;N-methyl glyoxaline
- CBNumber
- CB1316726
- Molecular Formula
- C4H6N2
- Formula Weight
- 82.1
- MOL File
- 616-47-7.mol
1-Methylimidazole Property
- Melting point:
- −60 °C(lit.)
- Boiling point:
- 198 °C(lit.)
- Density
- 1.03 g/mL at 25 °C(lit.)
- vapor pressure
- 0.4 mm Hg ( 20 °C)
- refractive index
- n20/D 1.495(lit.)
- Flash point:
- 198 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- pka
- 6.95(at 25℃)
- Specific Gravity
- 1.031
- color
- Clear colorless to yellow
- PH
- 9.5-10.5 (50g/l, H2O, 20℃)
- PH Range
- 9.5 - 11.5 at 100 g/l at 20 °C
- explosive limit
- 2.7-15.7%(V)
- Water Solubility
- Miscible with water.
- Sensitive
- Hygroscopic
- BRN
- 105197
- Stability:
- Stable, but moisture sensitive. Incompatible with acids, acid anhydrides, strong oxidizing agents, moisture, carbon dioxide, acid chlorides.
- InChIKey
- MCTWTZJPVLRJOU-UHFFFAOYSA-N
- LogP
- -0.19 at 25℃
- CAS DataBase Reference
- 616-47-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-Imidazole, 1-methyl-(616-47-7)
- EPA Substance Registry System
- 1H-Imidazole, 1-methyl- (616-47-7)
Safety
- Hazard Codes
- C,Xn,F,T
- Risk Statements
- 21/22-34-19-11-20/21/22-52/53-24-22-40-37-21
- Safety Statements
- 26-36-45-1/2-36/37/39-16-33-29-61
- RIDADR
- UN 3267 8/PG 2
- WGK Germany
- 1
- RTECS
- NI7000000
- F
- 3-10
- Autoignition Temperature
- 977 °F
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29332990
- Toxicity
- LD50 orally in Rabbit: 1144 mg/kg LD50 dermal Rabbit > 400 - < 640 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MX1123
- Product name
- 1-Methylimidazole
- Packaging
- 4L
- Price
- $1120
- Updated
- 2024/03/01
- Product number
- 8.05852
- Product name
- 1-Methylimidazole
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $64.5
- Updated
- 2024/03/01
- Product number
- 8.05852
- Product name
- 1-Methylimidazole
- Purity
- for synthesis
- Packaging
- 1L
- Price
- $404
- Updated
- 2024/03/01
- Product number
- 336092
- Product name
- 1-Methylimidazole
- Purity
- ≥99%, purified by redistillation
- Packaging
- 1l
- Price
- $395
- Updated
- 2024/03/01
- Product number
- 336092
- Product name
- 1-Methylimidazole
- Purity
- ≥99%, purified by redistillation
- Packaging
- 2l
- Price
- $584
- Updated
- 2024/03/01
1-Methylimidazole Chemical Properties,Usage,Production
Chemical Properties
1-Methylimidazole or N-methylimidazole is an aromatic heterocyclic organic compound with the formula CH3C3H3N2. It is a colorless to yellow liquid, with an amine-like odor. It is miscible with water. N-methylimidazole is an important raw material for the synthesis of pharmaceutical intermediates, used in the preparation of losartan, nizofenone, 1-Methyl-1H-imidazole-5-carbonyl chloride hydrochloride and naphazoline hydrochloride, etc. It is also used as a specialty solvent, a base, and as a precursor to some ionic liquids.
Uses
1-Methylimidazole is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate. It is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.
Uses
1-Methylimidazole is an aprotic solvent. It is a derivative of imidazole used in the production of pharmaceuticals, pesticides, ion exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It can also be used as a catalyst for the manufacture of polyurethane and a curing agent for epoxy resins. For example, when 1-methylimidazole is added to an aqueous diethylenetriamine (DETA) solution, high CO2 loading can be achieved through phase separation of the absorbent during CO2 absorption[1].
Preparation
1-Methylimidazole is prepared mainly by two routes industrially. The main one is acid-catalysed methylation of imidazole by methanol. The second method involves the Radziszewski reaction from glyoxal, formaldehyde, and a mixture of ammonia and methylamine.
(CHO)2 + CH2O + CH3NH2 + NH3 → H2C2N(NCH3)CH + 3 H2O
The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation.
H2C2N(NH)CH + CH3I → [H2C2(NH)(NCH3)CH]I
[H2C2(NH)(NCH3)CH]I + NaOH → H2C2N(NCH3)CH + H2O + NaI
Definition
ChEBI: 1-methyl-1H-imidazole is a 1H-imidazole having a methyl substituent at the N-1 position. It is a metabolite of 1-methyl-2-thioimidazole (methimazole). It inhibits bone resorption.
General Description
This product has been enhanced for catalysis. 1-Methylimidazole is a derivative of imidazole that is utilized in the manufacture of such classes of items as pharmaceuticals, pesticides, ion-exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It is also used as a catalyst for manufacturing polyurethanes and a curing agent for epoxy resins.
Flammability and Explosibility
Not classified
Purification Methods
Dry it with sodium metal and then distil it. Store it at 0o under dry argon. The picrate has m 159.5-160.5o (from H2O). [Beilstein 23 III/IV 568.]
References
[1] You J, et al. Effect of 1-Methylimidazole on CO2 Absorption by Diethylenetriamine (DETA) Aqueous Solutions. Chemical Engineering & Technology, 2017; 40: 2238-2242.
1-Methylimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Methylimidazole manufacturers
- Product
- 1-Methylimidazole 616-47-7
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500mg/year
- Release date
- 2021-07-09
- Product
- 1-Methylimidazole 616-47-7
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- More than 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-04-29
- Product
- 1-Methylimidazole 616-47-7
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-24