ARV-771
- Product Name
- ARV-771
- CAS No.
- 1949837-12-0
- Chemical Name
- ARV-771
- Synonyms
- ARV-771;ARV 771; ARV771;Epigenetic Reader Domain,ARV-771,ARV771,inhibit,ARV 771,PROTACs,Inhibitor;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-;(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
- CBNumber
- CB13167639
- Molecular Formula
- C49H60ClN9O7S2
- Formula Weight
- 986.65
- MOL File
- 1949837-12-0.mol
ARV-771 Property
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:65.92(Max Conc. mg/mL);68.22(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);20.7(Max Conc. mM)
DMF:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.14(Max Conc. mM)
Ethanol:55.0(Max Conc. mg/mL);56.92(Max Conc. mM) - form
- A crystalline solid
- pka
- 13.61±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21299
- Product name
- ARV-771
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 21299
- Product name
- ARV-771
- Packaging
- 10mg
- Price
- $253
- Updated
- 2024/03/01
- Product number
- 21299
- Product name
- ARV-771
- Packaging
- 5mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- 7256
- Product name
- ARV771
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $219
- Updated
- 2021/12/16
- Product number
- CS-6389
- Product name
- ARV-771
- Purity
- 99.82%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
ARV-771 Chemical Properties,Usage,Production
Description
ARV-771 is a BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2), respectively.
Uses
ARV-771 is an effective BET degrader of the PROTAC class.
Biological Activity
ARV-771 is a potent pan-(bromodomain and extra-terminal) BET degrader, a novel BET-PROTAC (proteolysis-targeting chimera), for BRD2(1), BRD2(2), BRD3(1) The Kd values of , BRD3(2), BRD4(1) and BRD4(2) were 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM, respectively.
target
Target | Value |
BRD2-BD2 (Cell-free assay) | 4.7 nM(Kd) |
BRD3-BD2 (Cell-free assay) | 7.6 nM(Kd) | td>
BRD4-BD2 (Cell-free assay) | 7.6 nM(Kd) |
BRD3-BD1 (Cell-free assay) | 8.3 nM(Kd) | tr>
BRD4-BD1 (Cell-free assay) | 9.6 nM(Kd) |
storage
Store at -20°C
ARV-771 Preparation Products And Raw materials
Raw materials
Preparation Products
ARV-771 Suppliers
- Tel
- 13606124132;13656121842
- luyan0021@163.com
- Country
- China
- ProdList
- 220
- Advantage
- 58
- Tel
- 15623560702
- Joy.Ren@aliyun.com
- Country
- China
- ProdList
- 139
- Advantage
- 58
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 18089
- Advantage
- 64
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9452
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12357
- Advantage
- 58
- Tel
- 021-52996696,15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4153
- Advantage
- 55
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4573
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24971
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- Country
- China
- ProdList
- 1988
- Advantage
- 58
- Tel
- 400-6387771-6038 18902104717
- sales@heowns.com
- Country
- China
- ProdList
- 20532
- Advantage
- 60
- Tel
- 021-021-00000000 18221039705
- Fax
- QQ:17263424
- finetechpharm@126.com
- Country
- China
- ProdList
- 180
- Advantage
- 58
- Tel
- 021-54338626 18017892860
- Fax
- 021-54338626
- sales@tubepharm.com
- Country
- China
- ProdList
- 2329
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
- Tel
- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- 13504435624
- 1927928688@qq.com
- Country
- China
- ProdList
- 1294
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19105
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10523
- Advantage
- 58
- Tel
- +8618530059196
- sale04@alfachem.cn
- Country
- China
- ProdList
- 12733
- Advantage
- 58
- Tel
- +86-27-59207850 +86-13986145403
- Fax
- 86-27-59524646
- info@fortunachem.com
- Country
- China
- ProdList
- 6003
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6313
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 13173652190
- pomy@tanzhenbio.com
- Country
- China
- ProdList
- 1586
- Advantage
- 58
- Tel
- 15869524721
- 3525679403@qq.com
- Country
- China
- ProdList
- 3694
- Advantage
- 58
- Tel
- 0371-0371-53732842 13383863444
- Fax
- QQ:3002612166
- 3002612166@qq.com
- Country
- China
- ProdList
- 10014
- Advantage
- 58
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10007
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7955
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 9946
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44489
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 3061
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 7977
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 6975
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 6637
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- product02@bidepharm.com
- Country
- China
- ProdList
- 61720
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6712
- Advantage
- 58
- Tel
- 21-21-20222982 13124863828
- sales@linkchem.cn
- Country
- China
- ProdList
- 2986
- Advantage
- 58
- Tel
- 17771424646
- shoubull@126.com
- Country
- China
- ProdList
- 966
- Advantage
- 58
- Tel
- 2122619822
- czbjpharma@126.com
- Country
- China
- ProdList
- 18488
- Advantage
- 58
- Tel
- 0431-80514535 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 5061
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24023
- Advantage
- 58
- Tel
- 0724-4355788 19307246857
- 15327516800@163.com
- Country
- China
- ProdList
- 797
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29803
- Advantage
- 58
View Lastest Price from ARV-771 manufacturers
- Product
- ARV-771 1949837-12-0
- Price
- US $0.00-0.00/MG
- Min. Order
- 1MG
- Purity
- 98
- Supply Ability
- 100G
- Release date
- 2024-04-17
- Product
- ARV-771 1949837-12-0
- Price
- US $0.00/mg
- Min. Order
- 1mg
- Purity
- 98%min
- Supply Ability
- 500mg
- Release date
- 2021-08-26