Betamethasone 17-valerate
- Product Name
- Betamethasone 17-valerate
- CAS No.
- 2152-44-5
- Chemical Name
- Betamethasone 17-valerate
- Synonyms
- BETAMETHASONE VALERATE;VALISONE;Betaderm;BETNOVATE;BETHAMETASONE VALERATE;Luxiq;Betoid;Valison;9α-Fluo;Deviphos
- CBNumber
- CB1317879
- Molecular Formula
- C27H37FO6
- Formula Weight
- 476.58
- MOL File
- 2152-44-5.mol
Betamethasone 17-valerate Property
- Melting point:
- 183-184°
- alpha
- D +77° (dioxane)
- Boiling point:
- 598.9±50.0 °C(Predicted)
- Density
- 1.1174 (estimate)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
- pka
- 12.90±0.70(Predicted)
- form
- Solid
- color
- White
- Merck
- 13,1183
- BRN
- 4240001
- InChIKey
- SNHRLVCMMWUAJD-SUYDQAKGSA-N
- SMILES
- [C@]12(C)C[C@@H]([C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@@]3([H])[C@]1([H])C[C@H](C)[C@@]2(C(=O)CO)OC(=O)CCCC)O |&1:0,3,4,6,16,18,21,23,r|
- CAS DataBase Reference
- 2152-44-5(CAS DataBase Reference)
- EPA Substance Registry System
- .beta.-Methasone 17-valerate (2152-44-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B0515
- Product name
- Betamethasone 17-valerate
- Packaging
- 25mg
- Price
- $98.5
- Updated
- 2024/03/01
- Product number
- 1069007
- Product name
- Betamethasone valerate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 25640
- Product name
- Betamethasone 17-valerate
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 25640
- Product name
- Betamethasone 17-valerate
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- Y0001027
- Product name
- Betamethasone valerate for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001027
- Price
- $153
- Updated
- 2024/03/01
Betamethasone 17-valerate Chemical Properties,Usage,Production
Description
Betamethasone 17-valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone. Betamethasone 17-valerate is often used to treat mild eczema with good efficacy and lower incidence of steroid induced adverse effects due to its lower potency compared to other glucocorticoids. It is available in cream, ointment, lotion, and foam preparations for topical use.
Chemical Properties
White Solid
Originator
Valisone,Schering,US,1967
Uses
Betamethasone 17-Valerate is a glucocorticoid with anti-inflammatory properties and immunosuppressive activity. It is an antiepileptic non-selective phosphodiesterase inhibitor. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man. As a medium-strength corticosteroid, this medication is used to treat a variety of skin conditions (such as eczema, dermatitis, allergies, rash). Betamethasone reduces the swelling, itching, and redness that can occur in these types of conditions.
Definition
ChEBI: Betamethasone valerate is a steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester. It has a role as an anti-inflammatory drug. It is a steroid ester, a 20-oxo steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a primary alpha-hydroxy ketone. It is functionally related to a betamethasone.
Indications
Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid.
Manufacturing Process
The valerate is made from betamethasone as a starting material as follows: A
suspension of 9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-
3,20-dione(betamethasone) (2 grams) in sodium dried benzene (500 ml) was
distilled vigorously for a few minutes, toluene-p-sulfonic acid monohydrate (30
mg) and methyl orthovalerate (5 ml) were added and distillation was
continued for 10 minutes. The mixture was then boiled under reflux for 1.5
hours after which time unreacted betamethasone alcohol (400 mg) was
removed by filtration. The benzene solution was treated with solid sodium
.bicarbonate and a few drops of pyridine, filtered and evaporated to dryness
at about 50°C. The residue, in ether, was filtered through grade III basic
alumina (20grams) to remove traces of unreacted betamethasone alcohol, the
ether removed in vacuo and the residue of crude betamethasone 17,21-
methyl orthovalerate was treated with acetic acid (20ml) and a few drops of
water and left overnight at room temperature.
The acetic acid solution was poured into water (100 ml) and extracted with
chloroform. The chloroform extracts were washed in turn with water, saturated
sodium bicarbonate solution and water, dried and evaporated in vacuo. The
residual gum was triturated with ether and a white crystalline solid (1.16
grams) isolated by filtration. Recrystallization from ether (containing a small
amount of acetone)-petroleum ether gave 9α-fluoro-11β,21-dihydroxy-16β-
methyl-17α-valeryloxypregna-1,4-diene-3,20-dione (871 mg) as fine needles.
brand name
Betatrex (Savage); Luxiq (Connetics); Valisone (Schering).
Therapeutic Function
Corticosteroid
Biochem/physiol Actions
Betamethasone 17-valerate is a synthetic glucocorticoid. It exhibitstherapeutic effects against various allergic and inflammatory skin diseases. Betamethasone 17-valerate also possesses anti-inflammatory properties.
Side effects
Common side effects. These may affect up to 1 in 10 people:
a. itchy skin. b. local skin burning or pain Very rare side effects.
These may affect up to 1 in 10,000 people.
Use of Betnovate Scalp Application for a long period of time, or use under an airtight dressing, may cause the following symptoms:
c. increased weight. d. moon face / rounding of theface. e. obesity. f. skin thinning, this may cause stretch marks. g. skin wrinkling. h. skin dryness. i. the appearance of blood vessels under the surface of your skin. j. changes to the colour of yourskin. k. increased body hair
l. hair loss / lack of hair growth / damaged looking hair.
Other very rare skin reactions that may occur are:
m. allergic reaction at the site ofapplication. n. worsening of condition. o. application site irritation. p. redness. q. rash or hives. r. If you have psoriasis you may get raised bumps with pus under the skin. This can happen very rarely during or after treatment and is known as pustular psoriasis.
s. skin infection.
In children also look out for the following symptoms:
t. delayed weight gain
u. slow growth.
Betamethasone 17-valerate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Betamethasone 17-valerate manufacturers
- Product
- Betamethasone Valerate 2152-44-5
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 99% up, High Density
- Supply Ability
- 20 tons
- Release date
- 2023-04-24
- Product
- Betamethasone 17-valerate 2152-44-5
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 97%-103% HPLC
- Supply Ability
- 100KGS
- Release date
- 2021-06-24
- Product
- Betamethasone 17-valerate/BetaMethasone valerate 2152-44-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2023-07-27