ChemicalBook > CAS DataBase List > Betamethasone 17,21-dipropionate

Betamethasone 17,21-dipropionate

Product Name
Betamethasone 17,21-dipropionate
CAS No.
5593-20-4
Chemical Name
Betamethasone 17,21-dipropionate
Synonyms
S 3440;Psorion;Maxivate;diprosis;Diprophos;Sch 11460;diproderm;diprolene;diprosone;Rinderon DP
CBNumber
CB3676725
Molecular Formula
C28H37FO7
Formula Weight
504.6
MOL File
5593-20-4.mol
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Betamethasone 17,21-dipropionate Property

Melting point:
178 °C
alpha 
D26 +65.7° (dioxane)
Boiling point:
603.2±55.0 °C(Predicted)
Density 
1.1481 (estimate)
refractive index 
69 ° (C=1, Dioxane)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form 
neat
pka
12.87±0.70(Predicted)
Merck 
1180
InChIKey
CIWBQSYVNNPZIQ-JCOVECCMSA-N
CAS DataBase Reference
5593-20-4(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
TU4058000
HS Code 
29372290
Toxicity
LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1040000
Product name
Betamethasone dipropionate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
Y0001416
Product name
Betamethasone dipropionate for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
B1152
Product name
Betamethasone 17,21-dipropionate
Purity
≥97.0%
Packaging
1g
Price
$231
Updated
2021/03/22
Sigma-Aldrich
Product number
1067704
Product name
Betamethasone dipropionate
Packaging
125mg
Price
$297
Updated
2021/03/22
Sigma-Aldrich
Product number
B1152
Product name
Betamethasone 17,21-dipropionate
Purity
≥97.0%
Packaging
100mg
Price
$44.7
Updated
2021/03/22
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Betamethasone 17,21-dipropionate Chemical Properties,Usage,Production

Chemical Properties

Betamethasone 17,21-dipropionate is Pale Yellow Foam

Originator

Betnovate,Glaxo,UK,1961

Uses

 Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.

Uses

antiviral

Uses

Cortico Steroids

Definition

Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.

Manufacturing Process

A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'- ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid (20 ml), containing 2 drops of water, was allowed to stand at room temperature for 5 hours. Dilution of the mixture with water gave a white solid (457 mg) which, after being filtered off and dried, was recrystallized from acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α- propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and acidification with dilute hydrochloric acid gave the crude diester. Recrystallization from acetone-petroleum ether afforded betamethasone 17,21-dipropionate (649 mg), MP 117°C (decomposition).

brand name

Alphatrex (Savage); Diprolene (Schering).

Therapeutic Function

Glucocorticoid

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.

Betamethasone 17,21-dipropionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Betamethasone 17,21-dipropionate Suppliers

Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586-
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
146
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
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China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
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62
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
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61
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
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56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
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Energy Chemical
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021-58432009-
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021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43494
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61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
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62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
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inquiries@lgmpharma.com
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United States
ProdList
1938
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70
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19999
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64
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View Lastest Price from Betamethasone 17,21-dipropionate manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Betamethasone 17,21-dipropionate 5593-20-4
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-16
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Betamethasone 17,21-dipropionate 5593-20-4
Price
US $0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2020-09-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Betamethasone dipropionate 5593-20-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
97%-103%; USP
Supply Ability
100kg
Release date
2021-06-02

5593-20-4, Betamethasone 17,21-dipropionateRelated Search:


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  • propionic acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-3-keto-10,13,16-trimethyl-17-(2-propionyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
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  • Betamethasone dipropionate solution in Acetonitrile, 100μg/mL
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  • Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-
  • Betamethasone 17,21-dipropionate USP/EP/BP
  • 5593-20-4
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