Betamethasone 17,21-dipropionate

Product Name: Betamethasone 17,21-dipropionate
CAS No.: 5593-20-4
Chemical Name: Betamethasone 17,21-dipropionate
Synonyms: BETAMETHASONE DIPROPIONATE;BetaMethasone dipropionat;diprolene;diprosone;Betamethasone 17;S 3440;Psorion;Maxivate;diprosis;Diprophos
CBNumber: CB3676725
Molecular Formula: C28H37FO7
Formula Weight: 504.6
MOL File: 5593-20-4.mol

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Betamethasone 17,21-dipropionate Property

Melting point:: 178 °C
alpha: D26 +65.7° (dioxane)
Boiling point:: 603.2±55.0 °C(Predicted)
Density: 1.1481 (estimate)
refractive index: 69 ° (C=1, Dioxane)
storage temp.: 2-8°C
solubility: Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form: Solid
pka: 12.87±0.70(Predicted)
color: White to Pale Yellow
Merck: 1180
InChIKey: CIWBQSYVNNPZIQ-JCOVECCMSA-N
SMILES: C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS DataBase Reference: 5593-20-4(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 2
RTECS: TU4058000
HS Code: 29372290
Toxicity: LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B1152
Product name: Betamethasone 17,21-dipropionate
Purity: ≥97.0%
Packaging: 1g
Price: $276
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1067704
Product name: Betamethasone dipropionate
Packaging: 125mg
Price: $358
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001925
Product name: Betamethasone dipropionate for system suitability A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001925
Price: $212
Updated: 2023/06/20

Sigma-Aldrich

Product number: Y0001416
Product name: Betamethasone dipropionate for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001416
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: B1152
Product name: Betamethasone 17,21-dipropionate
Purity: ≥97.0%
Packaging: 100mg
Price: $53.4
Updated: 2024/03/01

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Betamethasone 17,21-dipropionate Chemical Properties,Usage,Production

Chemical Properties

Betamethasone 17,21-dipropionate is Pale Yellow Foam

Originator

Betnovate,Glaxo,UK,1961

Uses

Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.

Uses

antiviral

Uses

Cortico Steroids

Definition

Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.

Manufacturing Process

A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'- ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid (20 ml), containing 2 drops of water, was allowed to stand at room temperature for 5 hours. Dilution of the mixture with water gave a white solid (457 mg) which, after being filtered off and dried, was recrystallized from acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α- propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and acidification with dilute hydrochloric acid gave the crude diester. Recrystallization from acetone-petroleum ether afforded betamethasone 17,21-dipropionate (649 mg), MP 117°C (decomposition).

brand name

Alphatrex (Savage); Diprolene (Schering).

Therapeutic Function

Glucocorticoid

Biochem/physiol Actions

Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.

Betamethasone 17,21-dipropionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Betamethasone 17,21-dipropionate Suppliers

Canada 2 China 331 Europe 3 France 2 Germany 3 India 36 Israel 3 Italy 1 Japan 2 Malaysia 2 Singapore 1 Spain 1 Switzerland 1 United Kingdom 7 United States 37 Global 432

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View Lastest Price from Betamethasone 17,21-dipropionate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Betamethasone dipropionate 5593-20-4
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 97%-103%; USP
Supply Ability: 100kg
Release date: 2021-06-02

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Betamethasone 17 5593-20-4
Price: US $2265.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 20 tons
Release date: 2022-10-20

Shaanxi Dideu Medichem Co. Ltd

Product: Betamethasone 17,21-dipropionate 5593-20-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000kg
Release date: 2024-08-01

5593-20-4, Betamethasone 17,21-dipropionateRelated Search:

Kresoxim-methyl Methylparaben Methyl acrylate Betamethasone Dilauryl thiodipropionate Betamethasone 21-phosphate disodium Bensulfuron methyl Betamethasone 17-valerate 16-beta Methyl Epoxide (r)-budesonide BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Methyl Betamethasone Impurity 38 Betamethasone-d3 Betamethasone 21-Acetate-17-propionate Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (11α,16β)- (9CI) Betamethasone-d5 Betamethasone 17-Propionate-d5 Betamethasone Dipropionate

BetaMethasone dipropionat

BETAMETHASONE DIPROPIONATE

BETAMETHASONE 17,21-DI-PROPIONATE

BETAMETHASONE 17-ALPHA,21-DIPROPIONATE

1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17,21-DIPROPIONATE

9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17,21-DIPROPIONATE

Betamethasonediproprionate

9--Fluoro-16--methyl-11,17,21-trihydroxy-1,4-pregnadiene-3,20-dione17,21-dipropionate

BETANMETHASONE DIPROPIONATE

BETAMETHASONEDIPROPIONATE,MICRONIZEDPOWDER,USP

Diprophos

Maxivate

Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)-

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 17,21-dipropionate (7CI, 8CI)

Psorion

Rinderon DP

S 3440

Sch 11460

β-Methasone 17,21-dipropionate

9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17,21-Dipropionate

17,21-Di(propionyloxy)-9-fluoro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione

[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

propionic acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-3-keto-10,13,16-trimethyl-17-(2-propionyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester

Betamethasone 17,21-dipropionate,9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

Betamethasone Dipropionate (125 mg)

Betamethasone 17,21-

Betamethasone 17

propanoic acid [2-[(8R,9S,10R,11S,13S,14R,16S,17R)-8-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(1-oxopropoxy)-6,7,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester

Betamethasone 17,21-dipropionate, ≥97.0%

9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

Betamethasone dipropionate for peak identification

Betamethasone dipropionate for system suitability

17,21 betaMethasone dipropionate ester

diproderm

diprolene

diprosis

diprosone

9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)

Betanmethasone Dipronate

Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11-Hydroxy-16-Methyl-17,21-Bis(1-Oxopropoxy)-,(11Beta,16Beta)-

(11-beta,16-beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate

Betamethaasone Dipropionate

Betamethasone 17,21-dipropionate(5593-20-4)

Betamethasone dipropionate for peak identification CRS

Betamethasone 17,21-Dipropionate &gt

Betamethasone dipropionate CRS

Diprolene AF

Betamethasone dipropionate for system suitability A

(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

Betamethasone dipropionate solution in Acetonitrile, 100μg/mL

Anhydrous Beclometasone Dipropionate

Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-

Betamethasone 17,21-dipropionate USP/EP/BP

Betamethasone 17,21-dipropionat

99% High Purity Raw Powder Betamethason 17, 21-Dipropionate CAS 5593-20-4

Betamethasone dipropionate (B1040000)Q: What is Betamethasone dipropionate (B1040000) Q: What is the CAS Number of Betamethasone dipropionate (B1040000)

Betamethasone dipropionate for peak identification (Y0001416)