Betamethasone 17,21-dipropionate
- Product Name
- Betamethasone 17,21-dipropionate
- CAS No.
- 5593-20-4
- Chemical Name
- Betamethasone 17,21-dipropionate
- Synonyms
- BETAMETHASONE DIPROPIONATE;BetaMethasone dipropionat;diprolene;diprosone;Betamethasone 17;S 3440;Psorion;Maxivate;diprosis;Diprophos
- CBNumber
- CB3676725
- Molecular Formula
- C28H37FO7
- Formula Weight
- 504.6
- MOL File
- 5593-20-4.mol
Betamethasone 17,21-dipropionate Property
- Melting point:
- 178 °C
- alpha
- D26 +65.7° (dioxane)
- Boiling point:
- 603.2±55.0 °C(Predicted)
- Density
- 1.1481 (estimate)
- refractive index
- 69 ° (C=1, Dioxane)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent).
- form
- Solid
- pka
- 12.87±0.70(Predicted)
- color
- White to Pale Yellow
- Merck
- 1180
- InChIKey
- CIWBQSYVNNPZIQ-JCOVECCMSA-N
- SMILES
- C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r|
- CAS DataBase Reference
- 5593-20-4(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 2
- RTECS
- TU4058000
- HS Code
- 29372290
- Toxicity
- LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B1152
- Product name
- Betamethasone 17,21-dipropionate
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $276
- Updated
- 2024/03/01
- Product number
- 1067704
- Product name
- Betamethasone dipropionate
- Packaging
- 125mg
- Price
- $358
- Updated
- 2024/03/01
- Product number
- Y0001925
- Product name
- Betamethasone dipropionate for system suitability A
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001925
- Price
- $212
- Updated
- 2023/06/20
- Product number
- Y0001416
- Product name
- Betamethasone dipropionate for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001416
- Price
- $220
- Updated
- 2024/03/01
- Product number
- B1152
- Product name
- Betamethasone 17,21-dipropionate
- Purity
- ≥97.0%
- Packaging
- 100mg
- Price
- $53.4
- Updated
- 2024/03/01
Betamethasone 17,21-dipropionate Chemical Properties,Usage,Production
Chemical Properties
Betamethasone 17,21-dipropionate is Pale Yellow Foam
Originator
Betnovate,Glaxo,UK,1961
Uses
Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.
Uses
antiviral
Uses
Cortico Steroids
Definition
Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.
Manufacturing Process
A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'-
ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid
(20 ml), containing 2 drops of water, was allowed to stand at room
temperature for 5 hours. Dilution of the mixture with water gave a white solid
(457 mg) which, after being filtered off and dried, was recrystallized from
acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α-
propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with
propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and
acidification with dilute hydrochloric acid gave the crude diester.
Recrystallization from acetone-petroleum ether afforded betamethasone
17,21-dipropionate (649 mg), MP 117°C (decomposition).
brand name
Alphatrex (Savage); Diprolene (Schering).
Therapeutic Function
Glucocorticoid
Biochem/physiol Actions
Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.
Safety Profile
Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.
Betamethasone 17,21-dipropionate Preparation Products And Raw materials
Raw materials
Preparation Products
Betamethasone 17,21-dipropionate Suppliers
- Tel
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
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View Lastest Price from Betamethasone 17,21-dipropionate manufacturers
- Product
- Betamethasone dipropionate 5593-20-4
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 97%-103%; USP
- Supply Ability
- 100kg
- Release date
- 2021-06-02
- Product
- Betamethasone 17 5593-20-4
- Price
- US $2265.00/kg
- Min. Order
- 1kg
- Purity
- 99% HPLC
- Supply Ability
- 20 tons
- Release date
- 2022-10-20
- Product
- Betamethasone 17,21-dipropionate 5593-20-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000kg
- Release date
- 2024-08-01