ChemicalBook > CAS DataBase List > Betamethasone 17,21-dipropionate

Betamethasone 17,21-dipropionate

Product Name
Betamethasone 17,21-dipropionate
CAS No.
5593-20-4
Chemical Name
Betamethasone 17,21-dipropionate
Synonyms
BETAMETHASONE DIPROPIONATE;BetaMethasone dipropionat;diprolene;diprosone;Betamethasone 17;S 3440;Psorion;Maxivate;diprosis;Diprophos
CBNumber
CB3676725
Molecular Formula
C28H37FO7
Formula Weight
504.6
MOL File
5593-20-4.mol
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Betamethasone 17,21-dipropionate Property

Melting point:
178 °C
alpha 
D26 +65.7° (dioxane)
Boiling point:
603.2±55.0 °C(Predicted)
Density 
1.1481 (estimate)
refractive index 
69 ° (C=1, Dioxane)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form 
Solid
pka
12.87±0.70(Predicted)
color 
White to Pale Yellow
Merck 
1180
InChIKey
CIWBQSYVNNPZIQ-JCOVECCMSA-N
SMILES
C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS DataBase Reference
5593-20-4(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
TU4058000
HS Code 
29372290
Toxicity
LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1152
Product name
Betamethasone 17,21-dipropionate
Purity
≥97.0%
Packaging
1g
Price
$276
Updated
2024/03/01
Sigma-Aldrich
Product number
1067704
Product name
Betamethasone dipropionate
Packaging
125mg
Price
$358
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001925
Product name
Betamethasone dipropionate for system suitability A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001925
Price
$212
Updated
2023/06/20
Sigma-Aldrich
Product number
Y0001416
Product name
Betamethasone dipropionate for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001416
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
B1152
Product name
Betamethasone 17,21-dipropionate
Purity
≥97.0%
Packaging
100mg
Price
$53.4
Updated
2024/03/01
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Betamethasone 17,21-dipropionate Chemical Properties,Usage,Production

Chemical Properties

Betamethasone 17,21-dipropionate is Pale Yellow Foam

Originator

Betnovate,Glaxo,UK,1961

Uses

Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.

Uses

antiviral

Uses

Cortico Steroids

Definition

Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.

Manufacturing Process

A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'- ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid (20 ml), containing 2 drops of water, was allowed to stand at room temperature for 5 hours. Dilution of the mixture with water gave a white solid (457 mg) which, after being filtered off and dried, was recrystallized from acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α- propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and acidification with dilute hydrochloric acid gave the crude diester. Recrystallization from acetone-petroleum ether afforded betamethasone 17,21-dipropionate (649 mg), MP 117°C (decomposition).

brand name

Alphatrex (Savage); Diprolene (Schering).

Therapeutic Function

Glucocorticoid

Biochem/physiol Actions

Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.

Betamethasone 17,21-dipropionate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Betamethasone 17,21-dipropionate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Betamethasone dipropionate 5593-20-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
97%-103%; USP
Supply Ability
100kg
Release date
2021-06-02
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Betamethasone 17 5593-20-4
Price
US $2265.00/kg
Min. Order
1kg
Purity
99% HPLC
Supply Ability
20 tons
Release date
2022-10-20
Shaanxi Dideu Medichem Co. Ltd
Product
Betamethasone 17,21-dipropionate 5593-20-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000kg
Release date
2024-08-01

5593-20-4, Betamethasone 17,21-dipropionateRelated Search:

Kresoxim-methyl Methylparaben Methyl acrylate Betamethasone Dilauryl thiodipropionate Betamethasone 21-phosphate disodium Bensulfuron methyl Betamethasone 17-valerate 16-beta Methyl Epoxide (r)-budesonide BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Methyl Betamethasone Impurity 38 Betamethasone-d3 Betamethasone 21-Acetate-17-propionate Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (11α,16β)- (9CI) Betamethasone-d5 Betamethasone 17-Propionate-d5 Betamethasone Dipropionate

  • BetaMethasone dipropionat
  • BETAMETHASONE DIPROPIONATE
  • BETAMETHASONE 17,21-DI-PROPIONATE
  • BETAMETHASONE 17-ALPHA,21-DIPROPIONATE
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17,21-DIPROPIONATE
  • 9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17,21-DIPROPIONATE
  • Betamethasonediproprionate
  • 9--Fluoro-16--methyl-11,17,21-trihydroxy-1,4-pregnadiene-3,20-dione17,21-dipropionate
  • BETANMETHASONE DIPROPIONATE
  • BETAMETHASONEDIPROPIONATE,MICRONIZEDPOWDER,USP
  • Diprophos
  • Maxivate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 17,21-dipropionate (7CI, 8CI)
  • Psorion
  • Rinderon DP
  • S 3440
  • Sch 11460
  • β-Methasone 17,21-dipropionate
  • 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17,21-Dipropionate
  • 17,21-Di(propionyloxy)-9-fluoro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
  • propionic acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-3-keto-10,13,16-trimethyl-17-(2-propionyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • Betamethasone 17,21-dipropionate,9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate
  • Betamethasone Dipropionate (125 mg)
  • Betamethasone 17,21-
  • Betamethasone 17
  • propanoic acid [2-[(8R,9S,10R,11S,13S,14R,16S,17R)-8-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(1-oxopropoxy)-6,7,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester
  • Betamethasone 17,21-dipropionate, ≥97.0%
  • 9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate
  • Betamethasone dipropionate for peak identification
  • Betamethasone dipropionate for system suitability
  • 17,21 betaMethasone dipropionate ester
  • diproderm
  • diprolene
  • diprosis
  • diprosone
  • 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
  • Betanmethasone Dipronate
  • Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11-Hydroxy-16-Methyl-17,21-Bis(1-Oxopropoxy)-,(11Beta,16Beta)-
  • (11-beta,16-beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate
  • Betamethaasone Dipropionate
  • Betamethasone 17,21-dipropionate(5593-20-4)
  • Betamethasone dipropionate for peak identification CRS
  • Betamethasone 17,21-Dipropionate &gt
  • Betamethasone dipropionate CRS
  • Diprolene AF
  • Betamethasone dipropionate for system suitability A
  • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
  • Betamethasone dipropionate solution in Acetonitrile, 100μg/mL
  • Anhydrous Beclometasone Dipropionate
  • Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-
  • Betamethasone 17,21-dipropionate USP/EP/BP
  • Betamethasone 17,21-dipropionat
  • 99% High Purity Raw Powder Betamethason 17, 21-Dipropionate CAS 5593-20-4
  • Betamethasone dipropionate (B1040000)Q: What is Betamethasone dipropionate (B1040000) Q: What is the CAS Number of Betamethasone dipropionate (B1040000)
  • Betamethasone dipropionate for peak identification (Y0001416)