ChemicalBook > CAS DataBase List > 2-IODO-3-HYDROXYPYRIDINE

2-IODO-3-HYDROXYPYRIDINE

Product Name
2-IODO-3-HYDROXYPYRIDINE
CAS No.
40263-57-8
Chemical Name
2-IODO-3-HYDROXYPYRIDINE
Synonyms
2-iodpyridin-3-ol;2-IODOPYRIDIN-3-OL;2-Iodopyridine-3-ol;3-Pyridinol, 2-iodo-;2-IODO-3-HYDROXYPYRIDINE;3-HYDROXY-2-IODOPYRIDINE;2-HYDROXY-3-IODOPYRIDINE;2-lodo-3-hydroxypyridine;3-Hydroxy-2-iodopyridine>Pyridine, 2-iodo-3-hydroxy-
CBNumber
CB1327625
Molecular Formula
C5H4INO
Formula Weight
221
MOL File
40263-57-8.mol
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2-IODO-3-HYDROXYPYRIDINE Property

Melting point:
193-195°C
Boiling point:
296.6±20.0 °C(Predicted)
Density 
2.142±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
4.74±0.10(Predicted)
form 
Crystalline Powder
color 
White to tan
Water Solubility 
Slightly soluble in water.
Sensitive 
Light Sensitive
BRN 
109836
InChI
InChI=1S/C5H4INO/c6-5-4(8)2-1-3-7-5/h1-3,8H
InChIKey
HJBGMPCMSWJZNH-UHFFFAOYSA-N
SMILES
C1(I)=NC=CC=C1O
CAS DataBase Reference
40263-57-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36-39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
675873
Product name
2-Iodo-3-hydroxypyridine
Purity
97%
Packaging
1g
Price
$80.2
Updated
2023/01/07
TCI Chemical
Product number
H1396
Product name
3-Hydroxy-2-iodopyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$78
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
HCH0011693
Product name
2-IODO-3-HYDROXY PYRIDINE
Purity
95.00%
Packaging
1G
Price
$635.71
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011693
Product name
2-IODO-3-HYDROXY PYRIDINE
Purity
95.00%
Packaging
5G
Price
$896.28
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011693
Product name
2-IODO-3-HYDROXY PYRIDINE
Purity
95.00%
Packaging
25G
Price
$1534.3
Updated
2021/12/16
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2-IODO-3-HYDROXYPYRIDINE Chemical Properties,Usage,Production

Uses

2-Iodo-3-hydroxypyridine acts as a reagent in the synthesis of the differentiating antibiotic azatyrosine

Synthesis

109-00-2

40263-57-8

General procedure for the synthesis of 2-iodo-3-hydroxypyridine using 3-hydroxypyridine as starting material: sodium carbonate (Na2CO3, 11.6 g, 109.72 mmol) and iodine (I2, 13.3 g, 52.57 mmol) were added sequentially to a solution of 3-hydroxypyridine (5.0 g, 52.57 mmol) in water (400 mL). The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the pH was adjusted to 4 with 1 M hydrochloric acid (HCl) solution. the precipitate was collected by filtration, washed with cold water and dried to give 2-iodo-3-hydroxypyridine (10.7 g, 92% yield) as a white powder. The product characterization data were as follows: melting point 189-190 °C (neat); thin layer chromatography (TLC) Rf = 0.33 (unfolding reagent dichloromethane/ethanol, 97/3, v/v); infrared spectroscopy (IR, KBr pressed) νmax (cm-1): 2851, 2722, 2573, 2345, 1560, 1455, 1301, 1189, 1121, 794, 668; nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6): δ10.88 (s, 1H, OH), 7.87 (dd, 1H, J1 = 1.6 Hz, J2 = 4.4 Hz, H-6), 7.24 (dd, 1H, J1 = 4.4 Hz, J2 = 8.0 Hz, H-5), 7.18 (dd, 1H, J1 = 1.6 Hz, J2 = 8.0 Hz, H-4); nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, DMSO-d6): δ 154.0, 141.8, 124.3, 121.3, 110.9; high resolution mass spectrometry (HRMS) calculated value of C5H4INO [M + H]+ 221.9410, measured value 221.9416.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 8, p. 944 - 947
[2] Tetrahedron, 2017, vol. 73, # 41, p. 6000 - 6007
[3] Patent: CN107793420, 2018, A. Location in patent: Paragraph 0009
[4] Roczniki Chemii, 1936, vol. 16, p. 502,507
[5] Chem. Zentralbl., 1937, vol. 108, # I, p. 3634

2-IODO-3-HYDROXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-IODO-3-HYDROXYPYRIDINE Suppliers

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View Lastest Price from 2-IODO-3-HYDROXYPYRIDINE manufacturers

Dideu Industries Group Limited
Product
2-IODO-3-HYDROXYPYRIDINE 40263-57-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-IODO-3-HYDROXYPYRIDINE 40263-57-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-IODO-3-HYDROXYPYRIDINE 40263-57-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

40263-57-8, 2-IODO-3-HYDROXYPYRIDINERelated Search:

2-Iodopyridine 3-Iodopyridine 3-Iodo-2-hydroxypyridine 2-Hydroxy-5-iodopyridine 3-Iodo-5-Hydroxypyridine 4-Iodo-2-hydroxypyridine 4-IODO-3-HYDROXYPYRIDINE 2-Iodo-5-hydroxypyridine 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE

  • (1,3-dioxo-2-isoindolyl)methyl-nitrocyanamide
  • 2- iodine-3- hydroxylpyridine
  • 3-Hydroxy-2-iodopyridine,98%
  • 2-IODO-3-HYDROXYPYRIDINE
  • 2-IODOPYRIDIN-3-OL
  • 3-HYDROXY-2-IODOPYRIDINE
  • 3-Pyridinol, 2-iodo-
  • Pyridine, 2-iodo-3-hydroxy-
  • 2-HYDROXY-3-IODOPYRIDINE
  • 3-Hydroxy-2-iodopyridine&gt
  • 2-IODO-3-HYDROXYPYRIDINE ISO 9001：2015 REACH
  • 2-Iodopyridine-3-ol
  • 2-iodpyridin-3-ol
  • 2-lodo-3-hydroxypyridine
  • 40263-57-8
  • 4026-35-7
  • C5H4NOI
  • alkyl Iodine| alcohol
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Halides
  • Pyridines
  • Pyridine