2-FLUORONICOTINIC ACID METHYL ESTER
- Product Name
- 2-FLUORONICOTINIC ACID METHYL ESTER
- CAS No.
- 446-26-4
- Chemical Name
- 2-FLUORONICOTINIC ACID METHYL ESTER
- Synonyms
- methyl 2-fluoronicotinate;2-fluoronicotin methyl ester;2-FLUORONICOTINIC ACID METHYL ESTER;Methyl 2-fluoro-3-pyridinecarboxylate;Methyl 2-fluoropyridine-3-carboxylate;3-Pyridinecarboxylicacid, 2-fluoro-, methyl ester;2-FLUORONICOTINIC ACID METHYL ESTER ISO 9001：2015 REACH
- CBNumber
- CB1327933
- Molecular Formula
- C7H6FNO2
- Formula Weight
- 155.13
- MOL File
- 446-26-4.mol
2-FLUORONICOTINIC ACID METHYL ESTER Property
- Melting point:
- 22-26 °C
- Boiling point:
- 75 °C/5 mmHg
- Density
- 1.243±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.47±0.10(Predicted)
- form
- liquid
- Appearance
- Colorless to light yellow Liquid
- InChIKey
- PJNHJXKXBSOLBH-UHFFFAOYSA-N
- CAS DataBase Reference
- 446-26-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 701904
- Product name
- Methyl 2-fluoropyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $163
- Updated
- 2023/06/20
- Product number
- M305530
- Product name
- Methyl2-fluoronicotinate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M305530
- Product name
- Methyl2-fluoronicotinate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- F13032
- Product name
- Methyl 2-fluoropyridine-3-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- N402
- Product name
- Methyl2-fluoronicotinate
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
2-FLUORONICOTINIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
40134-18-7
446-26-4
GENERAL METHOD: To a solution of methyl 2-chloronicotinate (1.00 g, 6.76 mmol) in DMSO (33.8 mL) was added CsF (2.053 g, 13.51 mmol) at room temperature. The reaction mixture was stirred at 110 °C for 20 h in air. Upon completion of the reaction, the reaction mixture was quenched with ice water and extracted with EtOAc (3 × 20 mL). The organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/EtOAc gradient elution) to afford methyl 2-fluoronicotinate (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. The synthesis of compounds 3B'-8B' was carried out with reference to the preparation steps of 2B'.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
2-FLUORONICOTINIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORONICOTINIC ACID METHYL ESTER Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 0311-0311-67790228 15531158659
- Fax
- 66571013
- 1257738041@qq.com
- Country
- China
- ProdList
- 297
- Advantage
- 62
- Tel
- +86(24) 31938773(O)
- Fax
- qq:174941352
- sales@co-chem.com
- Country
- China
- ProdList
- 225
- Advantage
- 62
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
View Lastest Price from 2-FLUORONICOTINIC ACID METHYL ESTER manufacturers
- Product
- 2-FLUORONICOTINIC ACID METHYL ESTER 446-26-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.3%
- Supply Ability
- 100 tons
- Release date
- 2022-02-22
- Product
- 2-FLUORONICOTINIC ACID METHYL ESTER 446-26-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 2-FLUORONICOTINIC ACID METHYL ESTER 446-26-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14