ChemicalBook > CAS DataBase List > 5-Amino-2,4,6-triiodoisophthalic acid

5-Amino-2,4,6-triiodoisophthalic acid

Product Name
5-Amino-2,4,6-triiodoisophthalic acid
CAS No.
35453-19-1
Chemical Name
5-Amino-2,4,6-triiodoisophthalic acid
Synonyms
ATIPA;5-AMino-2;Iohexol Impurity 8; Iohexol Impurity K;5-Amino-2,4,6-triiod;5-Amino-2,4,6-triiodo;Iohexol EP impurity K;Aminoiodoisophthalicacid;6-triiodoisophthalic acid;5-Amino-2,4,6-triiodoisophthaL
CBNumber
CB1329018
Molecular Formula
C8H4I3NO4
Formula Weight
558.84
MOL File
35453-19-1.mol
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5-Amino-2,4,6-triiodoisophthalic acid Property

Melting point:
265-270 °C (lit.)
Boiling point:
539.4±50.0 °C(Predicted)
Density 
3.053±0.06 g/cm3(Predicted)
vapor pressure 
10hPa at 20℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
pka
0.83±0.10(Predicted)
color 
Beige
InChI
InChI=1S/C8H4I3NO4/c9-3-1(7(13)14)4(10)6(12)5(11)2(3)8(15)16/h12H2,(H,13,14)(H,15,16)
InChIKey
JEZJSNULLBSYHV-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=C(I)C(N)=C(I)C(C(O)=O)=C1I
CAS DataBase Reference
35453-19-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
26-36/37/39
WGK Germany 
3
HS Code 
29224995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
444367
Product name
5-Amino-2,4,6-triiodoisophthalic acid
Purity
95%
Packaging
50g
Price
$169
Updated
2025/07/31
TCI Chemical
Product number
A1406
Product name
5-Amino-2,4,6-triiodoisophthalic Acid
Purity
>96.0%(T)
Packaging
25g
Price
$95
Updated
2025/07/31
TRC
Product number
A630810
Product name
5-Amino-2,4,6-triiodoisophthalic acid
Packaging
250g
Price
$275
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA00843
Product name
5-Amino-2,4,6-triiodoisophthalic acid
Packaging
500g
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA00843
Product name
5-Amino-2,4,6-triiodoisophthalic acid
Packaging
100g
Price
$85
Updated
2021/12/16
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5-Amino-2,4,6-triiodoisophthalic acid Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.

Uses

Intermediate for nonionic iodinated X-ray contrast agents.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

99-31-0

35453-19-1

Example 1 Synthesis of 5-amino-2,4,6-triiodoisophthalic acid In a 250 mL three-necked round-bottomed flask equipped with a thermometer, condenser, and magnetic stirrer, 5-aminoisophthalic acid (I) (3.86 g, 27.6 mmol) was dissolved in water (129.42 g), and pH was adjusted with 96% sulfuric acid (2 mL, 35.3 mmol) to 1. Subsequently, solid iodine (8.42 g, 33.2 mmol) was added, and the mixture was heated to 72 °C in an oil bath. An 18.65% (w/v) aqueous iodic acid solution (20 mL, 21.2 mmol) was slowly added via syringe pump over 5.2 h (addition rate 3.8 mL/h). After continuing the reaction at 72 °C for 1 h (total reaction time 6.2 h), the reaction mixture was cooled to room temperature and filtered. The resulting solid was washed with water and dried to afford 5-amino-2,4,6-triiodoisophthalic acid (II) (12.74 g, 22.8 mmol) as a pale pink solid in 82.6% yield. The product was analyzed by HPLC and compared with the standard to confirm that it meets the analytical specification of industrially produced 5-amino-2,4,6-triiodoisophthalic acid.

References

[1] Patent: EP2243767, 2010, A1. Location in patent: Page/Page column 8
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 19, p. 3611 - 3617
[3] Journal of Organic Chemistry, 1994, vol. 59, # 6, p. 1344 - 1350
[4] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 11, p. 3545 - 3554
[5] Patent: US2820814, 1955,

5-Amino-2,4,6-triiodoisophthalic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-2,4,6-triiodoisophthalic acid Suppliers

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View Lastest Price from 5-Amino-2,4,6-triiodoisophthalic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-19
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-26
Asia Chem I and E (Jiangsu) Co Ltd
Product
5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
Price
US $181.39/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.50%HPLC
Supply Ability
3tons/month
Release date
2021-09-16

35453-19-1, 5-Amino-2,4,6-triiodoisophthalic acidRelated Search:

5-Amino-2,4,6-triiodoisophthalic acid 4-IODO-3-METHYLANILINE 2-Iodo-1,3-dimethylbenzene 2-IODO-5-METHYLBENZOIC ACID 2-Iodobenzoic acid 4-IODO-3-METHYLBENZOIC ACID 4-IODO-M-XYLENE 4-Iodobenzoic acid 5-Aminoisophthalic acid 2,4-Diiodoaniline Isophthalic acid Iohexol 2-IODO-3-METHYLBENZOIC ACID 3-Amino-2,4,6-triiodobenzoic acid 2,4,6-TRIIODO-PHENYLAMINE 2-IODO-5-METHYLANILINE 3,5-DIMETHYL-4-IODOANILINE 2,4-DIIODO-3,5-DIMETHYLANILINE

  • ATIPA
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  • 5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC ACID
  • 5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID
  • 5-Amino-2,4,6-Triod-Isophthalic Acid
  • Aminoiodoisophthalicacid
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  • 5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID, 9 5%
  • 5-amino-2,4,6-triiodo isophthalic aicd
  • Amino-2,4,6-triiodoisophthalicAcid
  • Iohexol Impurity 8
  • 5-Amino-2,4,6-triiodoisophthalic acid (5-Atipa)
  • 5-AMIONOI 2,4,6, TRIIODOISOTHALIC ACID
  • 5, Amino 2,4,6 triidoisophthalic acid
  • Iohexol Impurity 11（Iohexol EP Impurity K）
  • 5-AMINO-2,4,6-TRIIODO-1,3-BENZENEDICARBOXYLIC ACID
  • 5-Amino-2,4,6-triiodo
  • 5-amino-2,4,6-triiodoisophthalic acid (intermediate of iohexol)
  • 2,4,6-Triodo Isophthalic Acid (ATIPA)
  • 5-Amino-2,4,6-triiod
  • 5-AMino-2
  • 6-triiodoisophthalic acid
  • 2,4,6-Triiodo-5-aminoisophthalic acid
  • 5- aMino-2,4,6- threeiodinebenzene between two forMic acid
  • 5-Amino-2,4,6-triiodoisophthalic acid 95%
  • Iohexol EP impurity K
  • 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylate
  • 5-Amino-2,4,6-triiodoisophthaL
  • 5-Amino-2,4,6-triiodoisophthalic Acid &gt
  • 2,4, 6-triiodine-5-amino-m-phthalic acid
  • 1,3-Benzenedicarboxylic acid, 5-amino-2,4,6-triiodo-
  • 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylicaci
  • 5-Amino-2,4,6-triiodobenzene-1,3-dicarboxylicacd
  • Iohexol Impurity K
  • 5-Amino-2,4,6-triiodoisopthalic acid
  • LAURIC ACID SODIUM SALT 629-25-4
  • 5-Amino-2,4,6-triaiodoisophthalic acid
  • 5-Amino-2,4,6-triiodoisophthaIic acid
  • 5-Amino-2,4,6-Triodoisopthaloyl Acid
  • 35453-19-1
  • H2NC6I313CO2H2
  • C8H4I3NO4
  • Aromatic Amino Acids
  • Peptide Synthesis
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Intermediate of Ioversol
  • Pyrimidines
  • Amines
  • Aromatics
  • Sulfur & Selenium Compounds
  • Aromatic Amino Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Organic acids
  • (intermediate of iohexol)