5-Amino-2,4,6-triiodoisophthalic acid

Product Name: 5-Amino-2,4,6-triiodoisophthalic acid
CAS No.: 35453-19-1
Chemical Name: 5-Amino-2,4,6-triiodoisophthalic acid
Synonyms: ATIPA;5-AMino-2;Iohexol Impurity 8; Iohexol Impurity K;5-Amino-2,4,6-triiod;5-Amino-2,4,6-triiodo;Iohexol EP impurity K;Aminoiodoisophthalicacid;6-triiodoisophthalic acid;5-Amino-2,4,6-triiodoisophthaL
CBNumber: CB1329018
Molecular Formula: C8H4I3NO4
Formula Weight: 558.84
MOL File: 35453-19-1.mol

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5-Amino-2,4,6-triiodoisophthalic acid Property

Melting point:: 265-270 °C (lit.)
Boiling point:: 539.4±50.0 °C(Predicted)
Density: 3.053±0.06 g/cm3(Predicted)
vapor pressure: 10hPa at 20℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Methanol
pka: 0.83±0.10(Predicted)
color: Beige
InChI: InChI=1S/C8H4I3NO4/c9-3-1(7(13)14)4(10)6(12)5(11)2(3)8(15)16/h12H2,(H,13,14)(H,15,16)
InChIKey: JEZJSNULLBSYHV-UHFFFAOYSA-N
SMILES: C1(C(O)=O)=C(I)C(N)=C(I)C(C(O)=O)=C1I
CAS DataBase Reference: 35453-19-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 42/43
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 29224995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444367
Product name: 5-Amino-2,4,6-triiodoisophthalic acid
Purity: 95%
Packaging: 50g
Price: $169
Updated: 2025/07/31

TCI Chemical

Product number: A1406
Product name: 5-Amino-2,4,6-triiodoisophthalic Acid
Purity: >96.0%(T)
Packaging: 25g
Price: $95
Updated: 2025/07/31

TRC

Product number: A630810
Product name: 5-Amino-2,4,6-triiodoisophthalic acid
Packaging: 250g
Price: $275
Updated: 2021/12/16

Matrix Scientific

Product number: 076231
Product name: 5-Amino-2,4,6-triiodoisophthalic acid
Purity: 95+%
Packaging: 25g
Price: $19
Updated: 2021/12/16

AK Scientific

Product number: E824
Product name: 5-Amino-2,4,6-triiodoisophthalic acid
Packaging: 25g
Price: $48
Updated: 2021/12/16

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5-Amino-2,4,6-triiodoisophthalic acid Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.

Uses

Intermediate for nonionic iodinated X-ray contrast agents.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

99-31-0

35453-19-1

Example 1 Synthesis of 5-amino-2,4,6-triiodoisophthalic acid In a 250 mL three-necked round-bottomed flask equipped with a thermometer, condenser, and magnetic stirrer, 5-aminoisophthalic acid (I) (3.86 g, 27.6 mmol) was dissolved in water (129.42 g), and pH was adjusted with 96% sulfuric acid (2 mL, 35.3 mmol) to 1. Subsequently, solid iodine (8.42 g, 33.2 mmol) was added, and the mixture was heated to 72 °C in an oil bath. An 18.65% (w/v) aqueous iodic acid solution (20 mL, 21.2 mmol) was slowly added via syringe pump over 5.2 h (addition rate 3.8 mL/h). After continuing the reaction at 72 °C for 1 h (total reaction time 6.2 h), the reaction mixture was cooled to room temperature and filtered. The resulting solid was washed with water and dried to afford 5-amino-2,4,6-triiodoisophthalic acid (II) (12.74 g, 22.8 mmol) as a pale pink solid in 82.6% yield. The product was analyzed by HPLC and compared with the standard to confirm that it meets the analytical specification of industrially produced 5-amino-2,4,6-triiodoisophthalic acid.

References

[1] Patent: EP2243767, 2010, A1. Location in patent: Page/Page column 8
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 19, p. 3611 - 3617
[3] Journal of Organic Chemistry, 1994, vol. 59, # 6, p. 1344 - 1350
[4] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 11, p. 3545 - 3554
[5] Patent: US2820814, 1955,

5-Amino-2,4,6-triiodoisophthalic acid Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 5-Amino-2,4,6-triiodoisophthalic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

Asia Chem I and E (Jiangsu) Co Ltd

Product: 5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1
Price: US $181.39/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.50%HPLC
Supply Ability: 3tons/month
Release date: 2021-09-16

35453-19-1, 5-Amino-2,4,6-triiodoisophthalic acidRelated Search:

5-Amino-2,4,6-triiodoisophthalic acid 4-IODO-3-METHYLANILINE 2-Iodo-1,3-dimethylbenzene 2-IODO-5-METHYLBENZOIC ACID 2-Iodobenzoic acid 4-IODO-3-METHYLBENZOIC ACID 4-IODO-M-XYLENE 4-Iodobenzoic acid 5-Aminoisophthalic acid 2,4-Diiodoaniline Isophthalic acid Iohexol 2-IODO-3-METHYLBENZOIC ACID 3-Amino-2,4,6-triiodobenzoic acid 2,4,6-TRIIODO-PHENYLAMINE 2-IODO-5-METHYLANILINE 3,5-DIMETHYL-4-IODOANILINE 2,4-DIIODO-3,5-DIMETHYLANILINE

ATIPA

5-AMINO-2,4,6-IODOISOPHTHALIC ACID

5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC ACID

5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID

5-Amino-2,4,6-Triod-Isophthalic Acid

Aminoiodoisophthalicacid

5-Amino-2,4,6-triiodoisophtalic acid

5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID, 9 5%

5-amino-2,4,6-triiodo isophthalic aicd

Amino-2,4,6-triiodoisophthalicAcid

Iohexol Impurity 8

5-Amino-2,4,6-triiodoisophthalic acid (5-Atipa)

5-AMIONOI 2,4,6, TRIIODOISOTHALIC ACID

5, Amino 2,4,6 triidoisophthalic acid

Iohexol Impurity 11（Iohexol EP Impurity K）

5-AMINO-2,4,6-TRIIODO-1,3-BENZENEDICARBOXYLIC ACID

5-Amino-2,4,6-triiodo

5-amino-2,4,6-triiodoisophthalic acid (intermediate of iohexol)

2,4,6-Triodo Isophthalic Acid (ATIPA)

5-Amino-2,4,6-triiod

5-AMino-2

6-triiodoisophthalic acid

2,4,6-Triiodo-5-aminoisophthalic acid

5- aMino-2,4,6- threeiodinebenzene between two forMic acid

5-Amino-2,4,6-triiodoisophthalic acid 95%

Iohexol EP impurity K

5-amino-2,4,6-triiodobenzene-1,3-dicarboxylate

5-Amino-2,4,6-triiodoisophthaL

5-Amino-2,4,6-triiodoisophthalic Acid &gt

2,4, 6-triiodine-5-amino-m-phthalic acid

1,3-Benzenedicarboxylic acid, 5-amino-2,4,6-triiodo-

5-amino-2,4,6-triiodobenzene-1,3-dicarboxylicaci

5-Amino-2,4,6-triiodobenzene-1,3-dicarboxylicacd

Iohexol Impurity K

5-Amino-2,4,6-triiodoisopthalic acid

LAURIC ACID SODIUM SALT 629-25-4

5-Amino-2,4,6-triaiodoisophthalic acid

5-Amino-2,4,6-triiodoisophthaIic acid

5-Amino-2,4,6-Triodoisopthaloyl Acid

35453-19-1

H2NC6I313CO2H2

C8H4I3NO4

Aromatic Amino Acids

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Intermediate of Ioversol

Pyrimidines

Amines

Aromatics

Sulfur & Selenium Compounds

Aromatic Amino Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives

Organic acids

(intermediate of iohexol)