2-Ethynylthiophene

Product Name: 2-Ethynylthiophene
CAS No.: 4298-52-6
Chemical Name: 2-Ethynylthiophene
Synonyms: 2-ETHYNYLTHIOPHENE;TIMTEC-BB SBB008821;(2-Thienyl)acetylene;2-Ethynylthiophene>Thiophene, 2-ethynyl-;2-Acetylenylthiophene;(Thien-2-yl)acetylene;2-Ethynylthiophene 90%;2-Ethynylthiophene 95+%;2-Ethynylthiophene ISO 9001：2015 REACH
CBNumber: CB1329098
Molecular Formula: C6H4S
Formula Weight: 108.16
MOL File: 4298-52-6.mol

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2-Ethynylthiophene Property

Boiling point:: 70℃/20Torr
Density: 1.080
refractive index: n20/D1.580
Flash point:: 42℃
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
form: clear liquid
color: Light yellow to Brown
InChI: InChI=1S/C6H4S/c1-2-6-4-3-5-7-6/h1,3-5H
InChIKey: LWISLHRIEATKTM-UHFFFAOYSA-N
SMILES: C1(C#C)SC=CC=1
CAS DataBase Reference: 4298-52-6

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Safety

Hazard Codes: Xi
Risk Statements: 10-36/37/38-36
Safety Statements: 16-23-26-36/37/39
RIDADR: UN 1993C 3 / PGIII
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS010938
Product name: 2-ethynylthiophene
Purity: Aldrich
Packaging: 100mg
Price: $128
Updated: 2025/07/31

TCI Chemical

Product number: E0915
Product name: 2-Ethynylthiophene
Purity: >96.0%(GC)
Packaging: 1g
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: E0915
Product name: 2-Ethynylthiophene
Purity: >96.0%(GC)
Packaging: 5g
Price: $296
Updated: 2025/07/31

TRC

Product number: E932198
Product name: 2-Ethynylthiophene
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Synthonix

Product number: E42371
Product name: 2-Ethynylthiophene
Purity: 95%
Packaging: 5g
Price: $100
Updated: 2021/12/16

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2-Ethynylthiophene Chemical Properties,Usage,Production

Chemical Properties

Clear yellow liquid

Uses

2-Ethynylthiophene is used in preparation of triazole derivative as Hsp90 inhibitors and anti-cancer metastasis drugs.

Definition

ChEBI: 2-Ethynylthiophene is a heteroarene.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 1487, 1976 DOI: 10.1021/jo00871a001
Synthesis, p. 589, 1996 DOI: 10.1055/s-1996-4265

Synthesis

40231-03-6

4298-52-6

The general procedure for the synthesis of 2-trimethylsilylthienylthiophene from 2-trimethylsilylthienylthiophene was as follows: 2-[(trimethylmethylsilyl)ethynyl]thiophene (1 mmol), an inorganic base (potassium tert-butoxide, sodium tert-butoxide, potassium hydroxide, sodium hydroxide, or potassium trimethylsilyl, sodium trimethylsilyl, 0.05 mmol), and 2 mL of DMA or DMSO solvent were added in turn to a 10-mL in a sealed tube. The reaction mixture was placed in an oil bath at 60 °C and stirred for 6 h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, an equal volume of homotrimethylene or n-undecane was added to the crude product. The exact yield of the product was determined by GC and GC-MS. The yields of the products were 59%, 66%, 75%, 77%, 92%, and 85% when DMSO was used as the reaction solvent and potassium tert-butanol, sodium tert-butanol, potassium hydroxide, sodium hydroxide, or potassium trimethylmethylsilyl, sodium trimethylmethylsilyl were used as the catalysts, respectively. When DMA was used as the reaction solvent, with the same catalyst, the yields of the products were 51%, 60%, 67%, 70%, 81%, 72%, respectively.

References

[1] Journal of Organic Chemistry, 1996, vol. 61, # 20, p. 6906 - 6921
[2] Patent: CN107459438, 2017, A. Location in patent: Paragraph 0080; 0081
[3] Organic Letters, 2017, vol. 19, # 19, p. 5182 - 5185
[4] Chemistry - A European Journal, 2018, vol. 24, # 15, p. 3725 - 3728
[5] Journal of Chemical Research, 2007, # 12, p. 728 - 732

2-Ethynylthiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Ethynylthiophene Suppliers

Americas 1 Belgium 1 China 149 Europe 2 Germany 1 India 5 Japan 1 United Kingdom 4 United States 23 Global 187

Shanghai Yao Sen Biotechnology Co., LTD

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View Lastest Price from 2-Ethynylthiophene manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2-Ethynylthiophene 4298-52-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-28

Career Henan Chemical Co

Product: 2-Ethynylthiophene 4298-52-6
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-10

4298-52-6, 2-EthynylthiopheneRelated Search:

Cephalothin sodium Trimethylsilylacetylene Thiophene Tetrahydrothiophene Thifensulfuron Acetylene ETHYNYLMAGNESIUM BROMIDE 1-BUTEN-3-YNE Dibenzothiophene 3-ETHYNYLTHIOPHENE 96 1-[5-(2-PHENYLETH-1-YNYL)-2-THIENYL]ETHAN-1-ONE ATRELEUTON 1-{5-[3-(DIMETHYLAMINO)PROP-1-YNYL]-2-THIENYL}ETHAN-1-ONE 5-(2-PHENYLETH-1-YNYL)THIOPHENE-2-CARBALDEHYDE 2-[(4-BROMOPHENYL)ETHYNYL] THIOPHENE 1-[5-(3-HYDROXYPROP-1-YNYL)-2-THIENYL]ETHAN-1-ONE 1-[5-(3-HYDROXY-3-METHYLBUT-1-YNYL)-2-THIENYL]ETHAN-1-ONE 2-Ethynylthiophene

2-ETHYNYLTHIOPHENE

TIMTEC-BB SBB008821

Thiophene, 2-ethynyl- (6CI, 7CI, 8CI, 9CI)

2-Ethynylthiophene 90%

(2-Thienyl)acetylene

2-Ethynylthiophene 95+%

(Thien-2-yl)acetylene

2-Acetylenylthiophene

Thiophene, 2-ethynyl-

2-Ethynylthiophene&gt

2-Ethynylthiophene ISO 9001：2015 REACH

4298-52-6

C6H4S

C4H3SCCH

Thiazoles

Thiophenes & Benzothiophenes