3-FLUOROCATECHOL

Product Name: 3-FLUOROCATECHOL
CAS No.: 363-52-0
Chemical Name: 3-FLUOROCATECHOL
Synonyms: 3-FLUOROCATECHOL;3-Fluorocatechol>3-Fluorocatechol,99%;3-Fluorocatechol 99%;3-FLUOROCATECHOL 98+%;3-Fluoro-1,2-benzenediol;3-FLUOROBENZENE-1,2-DIOL;3-Fluorobenznen-1,2-diol;3-Fluoro-2-hydroxy-phenol;1,2-Benzenediol, 3-fluoro-
CBNumber: CB1329210
Molecular Formula: C6H5FO2
Formula Weight: 128.1
MOL File: 363-52-0.mol

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3-FLUOROCATECHOL Property

Melting point:: 71-73 °C (lit.)
Boiling point:: 218.4±20.0 °C(Predicted)
Density: 1.5140
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 8.54±0.10(Predicted)
form: Crystalline Powder
color: Light beige to light brown-gray
Sensitive: Light Sensitive
BRN: 2436074
InChI: InChI=1S/C6H5FO2/c7-4-2-1-3-5(8)6(4)9/h1-3,8-9H
InChIKey: DXOSJQLIRGXWCF-UHFFFAOYSA-N
SMILES: C1(C(F)=CC=CC=1O)O
CAS DataBase Reference: 363-52-0(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 20/21/22-34
Safety Statements: 26-27-28-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29081990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0282
Product name: 3-Fluorocatechol
Purity: >98.0%(GC)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: F0282
Product name: 3-Fluorocatechol
Purity: >98.0%(GC)
Packaging: 5g
Price: $150
Updated: 2025/07/31

TRC

Product number: F588825
Product name: 3-Fluorocatechol
Packaging: 50g
Price: $1455
Updated: 2021/12/16

Matrix Scientific

Product number: 002989
Product name: 3-Fluorocatechol
Purity: 99%
Packaging: 1g
Price: $13
Updated: 2021/12/16

Apolloscientific

Product number: PC3728D
Product name: 3-Fluorobenzene-1,2-diol
Purity: 99%
Packaging: 1g
Price: $15
Updated: 2021/12/16

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3-FLUOROCATECHOL Chemical Properties,Usage,Production

Chemical Properties

light beige to light brown-grey crystalline powder

Uses

3-Fluorocatechol is a fluorinated catechol used in the preparation of synthetic humic acid as well as an intermediate in the preparation of 3-fluoroveratrole.

Definition

ChEBI: A catechol bearing an additional fluoro substituent at position 3.

Synthesis

367-12-4

363-52-0

The general procedure for the synthesis of 3-fluorocatechol from 2-fluorophenol was as follows: o-fluorophenol (20 g, 0.2 mol) was dissolved in acetonitrile (500 mL) dried over molecular sieves and stirred under argon protection. Anhydrous magnesium chloride (68 g, 0.72 mol) and triethylamine (150 mL, 1.08 mol) were then added and the mixture was observed to be exothermic. After stirring for 20 minutes, paraformaldehyde (42 g) was added and the reaction mixture was kept at 50 °C for 6 hours. The reaction process was monitored by thin layer chromatography (TLC) and it was found that there were still residues of raw materials, but the prolongation of the reaction time did not significantly change the results. Upon completion of the reaction, the mixture was cooled to room temperature and an aqueous sodium hydroxide solution (22.8 g of sodium hydroxide dissolved in 80 mL of water) was slowly added under ice water bath conditions. Then 30 wt% hydrogen peroxide (140 mL) was slowly added dropwise, taking care to control the reaction temperature below 50 °C to avoid intense exotherm. After the dropwise addition, the reaction mixture was continued to be stirred at 30°C for 1.5 hours. Subsequently, the pH was adjusted to 1 with concentrated hydrochloric acid (12 mol/L) and extracted with ethyl acetate (4 x 100 mL). The organic phases were combined and saturated aqueous sodium thiosulfate (200 mL) was added and stirred for 1 hour to remove residual peroxide. After separation of the organic phase, the aqueous phase was again extracted with ethyl acetate (1 x 100 mL). All organic phases were combined, dried and concentrated with anhydrous magnesium sulfate. Finally, the residue was purified by column chromatography (eluent was petroleum ether/ethyl acetate, 15:1, v/v) to afford 10.3 g of a light yellow oily liquid (Intermediate C-1a) in 45% yield and recovered 4.3 g of o-fluorophenol.The NMR hydrogen spectral (300 MHz, CDCl3) data for the Intermediate C-1a were as follows:δ 6.63-6.45 (3H, m), δ 120.3 (d, J = 15.5 Hz), 111.6 (d, J = 2.6 Hz), 108.1 (d, J = 18.4 Hz).

References

[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 7, p. 1429 - 1438
[2] Patent: CN104557654, 2017, B. Location in patent: Paragraph 0091-0093
[3] Tetrahedron Letters, 2005, vol. 46, # 19, p. 3357 - 3358
[4] Tetrahedron Letters, 2014, vol. 55, # 15, p. 2426 - 2429
[5] Patent: CN102850335, 2017, B. Location in patent: Paragraph 0018-0019

3-FLUOROCATECHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUOROCATECHOL Suppliers

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View Lastest Price from 3-FLUOROCATECHOL manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-FLUOROCATECHOL 363-52-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-04

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Fluorocatechol 363-52-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

Shaanxi Dideu Medichem Co. Ltd

Product: 3-FLUOROCATECHOL 363-52-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-06-11

363-52-0, 3-FLUOROCATECHOLRelated Search:

2-FLUORO-6-METHOXYPHENOL 2,3-Difluoro-6-methoxyphenol 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE TETRAFLUOROBENZENE-1,2-DIOL 3-FLUOROCATECHOL 4-FLUOROCATECHOL,4-Fluorocatechol 97%,4-Fluorocatechol97% Catechol 5,6,7,8-TETRAFLUOROBENZO-1,4-DIOXANE 1-FLUORO-2,3-DIMETHOXYBENZENE 2-FLUORO-3,4-DIMETHOXYPHENYLACETONITRILE 2-FLUORO-3,4-DIMETHOXYBENZYLCHLORIDE 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL CIS-(1S,2S)-1,2-DIHYDRO-3-FLUOROCATECHOL,CIS-(1S,2S)-1,2-DIHYDRO-3-FLUOROCATECHOL, 20 W/V% IN ETHYLACETATE FLUPAROXAN RARECHEM AL BK 0900 RARECHEM AL BE 0900 2-(ACETYLOXY)-3-FLUOROPHENYL ACETATE Acefluranol

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3-FLUOROCATECHOL 98+%

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3-Fluoro-2-hydroxy-phenol

363-52-0

FC6H312OH2

Aromatic Ethers

Phenol&Thiophenol&Mercaptan

Alcohols

Monomers

Polymer Science