ETANIDAZOLE Property

Melting point:

162-163° (Beaman); mp 164.5-165° (Lee)

Boiling point:

354.3°C (rough estimate)

Density 

1.4480 (rough estimate)

refractive index 

1.6700 (estimate)

storage temp. 

2-8°C

solubility 

Acetone (Slightly), Methanol (Slightly)

form 

Solid

pka

13.74±0.46(Predicted)

color 

White to Off-White

Stability:

Hygroscopic

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

NI3355000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

ETANIDAZOLE Chemical Properties,Usage,Production

Uses

Antineoplastic (hypoxic cell radiosensitizer).

Uses

Etanidazole is a kind of hypoxic radiosensitizer (a drug that sensitizes tumour cells to radiation therapy). Etanidazole is used in conjunction with Paclitaxel (P132500) to treat glioma, and is also used with Carboplatin (C177500) to treat advanced ovarian cancer.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.

brand name

Radinyl (Roberts Pharmaceutical).