Methyl phenylacetate

ChemicalBook > CAS DataBase List > Methyl phenylacetate

Methyl phenylacetate

Product Name: Methyl phenylacetate
CAS No.: 101-41-7
Chemical Name: Methyl phenylacetate
Synonyms: Methyl 2-phenylacetate;Methylphenylacetat;PHENYLACETIC ACID METHYL ESTER;2-phenylpropanoate;Methyl benzeneacetate;FEMA 2733;Mephaneine;METHYL A-TOLUATE;METHYLPAROXETINE;METHYL-PHENYLACETAT
CBNumber: CB1333473
Molecular Formula: C9H10O2
Formula Weight: 150.17
MOL File: 101-41-7.mol

Less

Methyl phenylacetate Property

Melting point:: 107-115 °C
Boiling point:: 218 °C (lit.)
Density: 1.066 g/mL at 20 °C (lit.)
vapor pressure: 16.9-75Pa at 20℃
refractive index: n20/D 1.503(lit.)
FEMA: 2733 | METHYL PHENYLACETATE
Flash point:: 195 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Methanol (Slightly)
color: Colourless
Odor: at 10.00 % in dipropylene glycol. sweet floral honey spice waxy almond
Odor Type: honey
Water Solubility: Miscible with water.
Merck: 14,7268
JECFA Number: 1008
BRN: 878795
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey: CRZQGDNQQAALAY-UHFFFAOYSA-N
LogP: 1.91-2.09 at 21.9-25℃
CAS DataBase Reference: 101-41-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzeneacetic acid, methyl ester(101-41-7)
EPA Substance Registry System: Methyl phenylacetate (101-41-7)

Less

Safety

Hazard Codes: Xn
Risk Statements: 21-R21
Safety Statements: 23-24/25
WGK Germany: 2
RTECS: AJ3175000
TSCA: Yes
HS Code: 29163500
Hazardous Substances Data: 101-41-7(Hazardous Substances Data)
Toxicity: The acute oral LD₅₀ in rats was reported as 2.55 g/kg (1.67-3.43 g/kg) and the acute dermal LD₅₀ in rabbits as 2.4 g/kg (0.15-4.7 g/kg) (Moreno, 1974).

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H303May be harmfulif swallowed

Precautionary statements

P403+P235Store in a well-ventilated place. Keep cool.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W273309
Product name: Methyl phenylacetate
Purity: ≥98%, FCC, FG
Packaging: 1kg
Price: $79.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: W273309
Product name: Methyl phenylacetate
Purity: ≥98%, FCC, FG
Packaging: 10Kg
Price: $461
Updated: 2024/03/01

Sigma-Aldrich

Product number: 108057
Product name: Methyl phenylacetate
Purity: ReagentPlus , ≥99%
Packaging: 100g
Price: $41.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: W273309
Product name: Methyl phenylacetate
Purity: ≥98%, FCC, FG
Packaging: 5kg
Price: $305
Updated: 2023/06/20

Sigma-Aldrich

Product number: 42958
Product name: Methyl phenylacetate
Purity: analytical standard
Packaging: 1ml
Price: $62.8
Updated: 2022/05/15

Less

Methyl phenylacetate Chemical Properties,Usage,Production

Chemical Properties

Methyl phenylacetate is a clear colorless liquid that is only slightly soluble in water, but very soluble in most organic solvents. It has a strong odor similar to honey. The odor is so strong that recommended smelling is of a solution with 10% or less methyl phenyl acetate. This compound also naturally occurs in brandy, capsicum, coffee, honey, pepper and some wine.

Occurrence

Reported found in cocoa, coffee, strawberry, pineapple, pepper, hop oil, cognac, peanut, honey, starfruit, Bourbon vanilla, mountain papaya, roasted chicory root and rooibus tea (Aspalathus linearis).

Uses

Methyl phenylacetate is utilized for partition coefficient measurement experiments. It is mainly used in the flavor industry and in perfumes to impart honey scents. Further, it acts as a precursor to prepare synthetic perfumes. It acts as an acylating agent and involved in the enantioselective acylation of beta-lactam intermediate using penicillin G amidase.

Preparation

Methyl phenylacetate is synthesized from phenylacetonitrile by hydrolysis and esterification. Put methanol into a dry glass-lined reaction pot, stir and cool to below 30°C, add sulfuric acid dropwise, heat up to 90°C after adding, and start adding phenylacetonitrile dropwise, control the temperature at about 95°C, and finish adding in 1.5h. After reacting at 95-100 °C for 6 h, it was cooled to below 40 °C and diluted with water equivalent to about 0.6 times the reaction solution. The acid water was separated by standing, and a saturated sodium carbonate solution was added for neutralization and washing, and the aqueous layer was discarded. It is dehydrated with anhydrous calcium chloride and fractionated under reduced pressure to obtain methyl phenylacetate with a yield of 80%.

Application

Methyl Phenylacetate is used as a reagent in the synthesis of various organic reactions, one of which is the synthesis of Vulpinic Acid; a lichen metabolite with anti-inflammatory properties. It is also used in the formulation of edible flavors, for the preparation of honey, chocolate, tobacco and other flavors; it can also be used in daily chemical flavors for the preparation of rose, oriental flavors and other flavors. IFRA has no restrictions.

Definition

ChEBI: Methyl benzeneacetate is a member of benzenes. It is a flavoring ingredient. Odoriferous constituent of many plants. It is generally found in brandy, capsicum, honey, pepper, some wine, coca and coca products.

Aroma threshold values

Detection: 25 ppb

Taste threshold values

Taste characteristics at 30 ppm: floral, fruity, honey, spice, waxy and sweet

Synthesis Reference(s)

Journal of the American Chemical Society, 93, p. 4919, 1971 DOI: 10.1021/ja00748a051
Tetrahedron Letters, 30, p. 2945, 1989 DOI: 10.1016/S0040-4039(00)99165-2

General Description

Methyl phenylacetate has been identified in the volatile fraction of beewax absolute oil, dried fruiting bodies of Boletus auripes, Chinese fermented black soybeans and peated malt.

Biochem/physiol Actions

Methyl phenylacetate undergoes decomposition on photolysis in methanol. Methyl phenylacetate acts as acylating agent and causes the enantioselective acylation of beta-lactam intermediate using penicillin G amidase. Methyl phenylacetate is the starting material in manufacture of synthetic perfumes.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Methyl phenylacetate Preparation Products And Raw materials

Raw materials

Glass-lined reaction pot Benzeneacetonitrile Metaclazepam Methanol Sulfuric acid Phenylacetic acid

Preparation Products

N-ISOPROPYLNORTROPINYL A HYDROXYMETHYL)PHENYLACETATE Tropic acid 8-isopropyl-8-azabicyclo[3.2.1]oct-3-yl endo-(±)-formylphenylacetate TROPYL A ORMULPHENYLACETATE Fluoxastrobin Methyl -formylphenylacetate METHYL ALPHA-BROMOPHENYLACETATE A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER 2-PHENYLMALONAMIDE

Less

Methyl phenylacetate Suppliers

Americas 1 Australia 1 Belgium 3 China 364 Czech Republic 1 Europe 2 France 1 Germany 12 India 56 Italy 2 Japan 8 Poland 1 Singapore 1 Slovakia 1 South Africa 1 South Korea 1 Spain 3 Switzerland 3 Ukraine 1 United Kingdom 10 United States 68 USA 1 Global 542

Beijing Holiyang Chemical Co. Ltd.

Tel: 13718199399
Fax: QQ : 206661479
Email: holiyangchem@163.com
Country: China
ProdList: 3387
Advantage: 56

hebei crovell biotech Co,.LTD

Tel: 19930503252
Email: mia@crovellbio.com
Country: China
ProdList: 1498
Advantage: 58

XI'AN VEDA CHEMICAL CO.,LTD

Tel: 029-88665278 13379235092
Email: sales@vedachem.com
Country: China
ProdList: 46
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Jinxiang Chemical (Danyang) Products Co., Ltd.

Tel: 025-86819862 13913839793
Fax: 0086-25-86819859
Email: nancyzong@jinchemical.com
Country: China
ProdList: 97
Advantage: 74

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12458
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9551
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

jiliang chemicals

Tel: 21-62165282 15801962796;
Fax: 021 61153784
Email: bidingchem@163.com
Country: China
ProdList: 1165
Advantage: 60

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3296
Advantage: 57

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18739
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11714
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 15343847665
Fax: QQ：3470079902
Email: huawenchem@163.com
Country: China
ProdList: 3206
Advantage: 55

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

Qingdao Free Trade Zone United International Co.,Ltd.

Tel: 0532-83893697 18561902820
Fax: 83893695
Email: sissili@unitedint.com
Country: China
ProdList: 352
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17779
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6139
Advantage: 55

Yurui (Shanghai) Chemical Co., Ltd.

Tel: 02150456736 13818239876
Fax: 021-50761379
Email: xin@riyngroup.com
Country: China
ProdList: 1136
Advantage: 30

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19918
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18216
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3933
Advantage: 58

Gow Chemical Corp. Limited

Tel: +86 (512) 8883-1178
Fax: +86 (512) 8217-5198
Country: China
ProdList: 17
Advantage: 55

RiZhao LiDeShi Chemical Co., Ltd.

Tel: 010-51268198
Fax: 010-63833209
Email: leadershipchem@126.com
Country: China
ProdList: 2549
Advantage: 58

Mei Lan Industrial (Shanghai) Co., Ltd.

Tel: 021-58958189
Fax: 021-58957967
Email: wouchina@126.com
Country: China
ProdList: 2671
Advantage: 55

Shanghai GaoLang Chemical Technology Co., Ltd.

Tel: 021-57340939 18017297327
Fax: 021-37210791
Email: sales@gaolangchemical.com
Country: China
ProdList: 888
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

Shanghai ideal Industrial Co., Ltd.

Tel: 021-58957966 18930537195
Fax: 021-60899437
Email: wouchina@126.com
Country: China
ProdList: 3033
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13358
Advantage: 58

GuangTuo Chemical (Shanghai) Co., Ltd.

Tel: 021-60899189-8001 18918189673
Fax: 021-60899304
Email: gtchem@126.com
Country: China
ProdList: 2661
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5223
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.

Tel: 021-69106960 13701823733
Fax: 021-69106780
Email: 13701823733@163.com
Country: China
ProdList: 4775
Advantage: 60

Shanghai YouPeng Chemical Co. Ltd.

Tel: 021-69005955 13701776567
Fax: 021-69005775
Email: youpengchem@163.com
Country: China
ProdList: 4303
Advantage: 56

Sichuan Hainuowei Technology Co. Ltd.

Tel: 13708085536
Fax: QQ : 121102042
Email: hanovichem@163.com
Country: China
ProdList: 3389
Advantage: 56

Shanghai TongYuan Chemical Co., Ltd.

Tel: 021-021-69182866 13701855675
Fax: 021-69182022
Email: tongyuanchem@126.com
Country: China
ProdList: 4331
Advantage: 58

Less

View Lastest Price from Methyl phenylacetate manufacturers

CONTIDE BIOTECH CO.,LTD

Product: Methyl phenylacetate 101-41-7
Price: US $10.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 20
Release date: 2024-03-21

Nanjing Deda New Material Technology Co., Ltd

Product: Methyl Phenylacetate 101-41-7
Price: US $10.00-5.00/kg
Min. Order: 1kg
Purity: 99.5
Supply Ability: 10 ton per month
Release date: 2023-11-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Methyl phenylacetate 101-41-7
Price: US $50.00/kg
Min. Order: 1kg
Purity: 80%
Supply Ability: 5000kg/Week
Release date: 2024-04-30

101-41-7, Methyl phenylacetateRelated Search:

Methyl acrylate Methyl isobutyrylacetate Methyl acetate Tribenuron methyl Methyl phenoxyacetate METSULFURON METHYL Methyl cyanoacetate Kresoxim-methyl Methyl salicylate Methyl bromoacetate Pirimiphos-methyl Thiophanate-methyl Methyl 8-Azoniabicyclo[3.2.1]octane, 8-methyl-8-(1-methylethyl)-3-[(phenylacetyl)oxy]-, bromide, (endo,syn)- (9CI) 3α-Phenylacetoxy Tropane endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol Benzeneacetic acid, α-methylene-, 1-methylethyl ester Atropic acid

Acetic acid, phenyl-, methyl ester

METHYL ALPHA-TOLUATE

METHYL BENZYLFORMATE

METHYL A-TOLUATE

METHYL PHENYLACETATE

FEMA 2733

Methyl phenylacetate/Phenylacetic acid methyl ester

Phenylacetic Acid Phenylacetate

METHYL PHENYLACETATE 98+% FCC

METHYL PHENYLACETATE, 99+%

Methyl phenylacetate (technical)

Phenylacetic acid, methyl ester (technical)

Methylphenylacetat

METHYL-PHENYLACETAT

METHYLPAROXETINE

PHENYLACETIC ACID METHYL ESTER

Methyl phenylacetate >=99.0%

Methyl phenylacetate, 99+% 250ML

Methyl phenylacetate Vetec(TM) reagent grade, 98%

2-Phenylacetic acid methyl

Phenylacetic acid methyl

Methyl phenylacetate ReagentPlus(R), >=99%

2-phenylpropanoate

Benzeneaceticacid,methylester

Mephaneine

Methyl 2-phenylacetate

Methyl benzeneacetate

Methyl ester of Phenylacetic acid

methyl phenylethanoate

methylalpha-phenylacetate

methylbenzeneacetate

methylbenzeneethanoate

methylphenylethanoate

phenyl-aceticacimethylester

MethylPhenylacetate&gt

Methyl DL-mandelate Powder

Methyl phenylacetate USP/EP/BP

Methyl phenylacetate(kosher)

Hotselling CAS?101-41-7?Methyl Phenylacetate

Ipratropium Bromide Impurity 24

Lenacapavir (GS-6207)

101-41-7

C6H5CH2CO2CH3

C6H5CH2COOCH3

C8 to C9

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Esters

Pharmaceutical Intermediates

flavoring

Organics

C8 to C9

Carbonyl Compounds

Esters

API intermediates

Alphabetical Listings

Flavors and Fragrances