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Atropic acid

Product Name
Atropic acid
CAS No.
492-38-6
Chemical Name
Atropic acid
Synonyms
NSC 20987;ATROPIC ACID;Atropic Acid >10029 ATROPIC ACID;2-PHENYLACRYLIC ACID;Cinacalcet ImpurityI;Α-PHENYLACRYLIC ACID;Atropic acid,492-38-6;2-Phenylpropenoic acid;Ipratropium Impurity D
CBNumber
CB3224700
Molecular Formula
C9H8O2
Formula Weight
148.16
MOL File
492-38-6.mol
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Atropic acid Property

Melting point:
106-107°
Boiling point:
bp ~267° with partial decompn
Density 
1.0061 (rough estimate)
refractive index 
1.5049 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.86±0.11(Predicted)
color 
White to Off-White
Water Solubility 
1.3g/L(20 ºC)
Merck 
14,874
Stability:
Light Sensitive
InChIKey
ONPJWQSDZCGSQM-UHFFFAOYSA-N
CAS DataBase Reference
492-38-6(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, «alpha»-methylene-(492-38-6)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-methylene- (492-38-6)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2390
Product name
Atropic Acid
Purity
>93.0%(GC)
Packaging
5g
Price
$55
Updated
2024/03/01
TCI Chemical
Product number
A2390
Product name
Atropic Acid
Purity
>93.0%(GC)
Packaging
25g
Price
$189
Updated
2024/03/01
TRC
Product number
A793850
Product name
Atropic Acid
Packaging
100mg
Price
$65
Updated
2021/12/16
TRC
Product number
A793850
Product name
Atropic Acid
Packaging
250mg
Price
$80
Updated
2021/12/16
TRC
Product number
A793850
Product name
Atropic Acid
Packaging
1g
Price
$105
Updated
2021/12/16
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Atropic acid Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid.

Uses

Atropic acid is an Impurity of Ipratropium bromide and Atropine Sulfate. Atropic acid and β,β-dimethylatropic acid are plant growth regulators.

Preparation

The synthesis of atropic acid involves several steps. Firstly, tropic acid is oxidized with hot KMnO4 to form benzoic acid. Secondly, tropic acid reacted with HBr to produce C9H9O2Br. Thirdly, C9H9O2Br is reacted with alcoholic KOH to yield atropic acid, C9H8O2. Finally, atropic acid is catalytically hydrogenated to form hydratropic acid, C9H10O2.

Reactions

Atropic acid is formed by the dehydration of tropic acid. Hence addition of water to atropic acid gives tropic acid.
Atropic acid, on oxidation yields benzoic acid. The formation of benzoic acid reveals that atropic acid and tropic acid contain atleast one benzene nucleus with a side chain containing carboxylic acid in their structure.

As atropic acid is an unsaturated acid it mean atropic acid may be either structure (I) or (II) .
Hence, the structure (II) is atropic acid which is confirmed by oxidation with KMnO4 to form phenylglyoxal.

Atropic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Atropic acid Suppliers

Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
Zhejiang Karry Pharmachem Co., Ltd.
Tel
19157666807
Email
info@karrypharma.com
Country
China
ProdList
38
Advantage
58
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451682 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
856
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
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View Lastest Price from Atropic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Atropic acid 492-38-6
Price
US $1.00-100.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
200000KG
Release date
2024-07-16
Wuhan Boyuan Import & Export Co., LTD
Product
2-Phenylacrylic acid 492-38-6
Price
US $9.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000tons
Release date
2023-05-25
Guangzhou Tosun Pharmaceutical Limited
Product
Ipratropium Bromide EP Impurity D 492-38-6
Price
US $0.00/mg
Min. Order
1mg
Purity
above 96%
Supply Ability
50mg
Release date
2023-05-22

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