azd4635

Product Name: azd4635
CAS No.: 1321514-06-0
Chemical Name: azd4635
Synonyms: CS-2744;azd4635;CPD1545;HTL-1071;Imaradenant;AZD4635 AZD-4635;AZD-4635; HTL-1071;Imaradenant (AZD4635);AZD4635, 10 mM in DMSO;AZD-4635; AZD 4635; AZD4635; HTL-1071; HTL 1071; HTL1071
CBNumber: CB13339854
Molecular Formula: C15H11ClFN5
Formula Weight: 315.73
MOL File: 1321514-06-0.mol

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azd4635 Property

Boiling point:: 491.5±55.0 °C(Predicted)
Density: 1.387±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:56.65(Max Conc. mg/mL);179.42(Max Conc. mM)
DMSO:PBS(pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.79(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);95.01(Max Conc. mM)
form: A crystalline solid
pka: 1.75±0.63(Predicted)
color: Off-white to yellow
InChI: InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
InChIKey: NCWQLHHDGDXIJN-UHFFFAOYSA-N
SMILES: N1C(C2C=C(C)N=C(Cl)C=2)=C(C2=CC=C(F)C=C2)N=C(N)N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26322
Product name: AZD 4635
Packaging: 5mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 26322
Product name: AZD 4635
Packaging: 10mg
Price: $229
Updated: 2024/03/01

Cayman Chemical

Product number: 26322
Product name: AZD 4635
Packaging: 25mg
Price: $469
Updated: 2024/03/01

Cayman Chemical

Product number: 26322
Product name: AZD 4635
Packaging: 50mg
Price: $869
Updated: 2024/03/01

TRC

Product number: A808255
Product name: AZD4635
Packaging: 1mg
Price: $55
Updated: 2021/12/16

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azd4635 Chemical Properties,Usage,Production

Uses

AZD4635, is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.

Synthesis

697739-22-3

1321517-59-2

1321514-06-0

6-Bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (1 mole-equivalent), 2-chloro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1 mole-equivalent), and K2CO3 (1.5 mole-equivalent) were used as raw materials suspended in a solvent mixture of 1,4-dioxane and water (v/v ratio 2 :1; 10 mL solvent/g 6-bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine). The mixture was degassed and dichlorobis[bis(4-dimethylaminophenyl)phosphino]palladium(II) (2 mol%) was added as a catalyst, and the reaction was heated and refluxed until complete consumption of 6-bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine was confirmed by LCMS monitoring. Upon completion of the reaction, the reaction mixture was cooled, diluted with water, extracted with dichloromethane and the organic phase was separated by a phase separator. The organic phase was concentrated under reduced pressure and purified by gradient fast chromatography using a mixture of ethyl acetate and hexane solvents as eluent to give the final target product 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine in 61% yield.

References

[1] Patent: WO2011/95625, 2011, A1. Location in patent: Page/Page column 177

azd4635 Preparation Products And Raw materials

Raw materials

Preparation Products

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azd4635 Suppliers

China 105 India 1 United States 7 Global 113

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View Lastest Price from azd4635 manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: azd4635 1321514-06-0
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-18

Career Henan Chemical Co

Product: azd4635 1321514-06-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-13

Career Henan Chemical Co

Product: azd4635 1321514-06-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-13

1321514-06-0, azd4635Related Search:

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azd4635

HTL-1071

CPD1545

6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine

1,2,4-Triazin-3-amine, 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-

AZD-4635; HTL-1071

AZD-4635; AZD 4635; AZD4635; HTL-1071; HTL 1071; HTL1071

CS-2744

Imaradenant

Imaradenant (AZD4635)

AZD4635 AZD-4635

AZD4635, 10 mM in DMSO

1321514-06-0

APIs