ChemicalBook > CAS DataBase List > AZD-0156

AZD-0156

Product Name
AZD-0156
CAS No.
1821428-35-6
Chemical Name
AZD-0156
Synonyms
AZ0156;AZ 0156;CS-2218;AZD-0156;AZD-0156, >98%;AZ0156;AZ 0156;AZD-0156;AZD 0156;AZD-0156,inhibit,Inhibitor,AZD0156,Ataxia telangiectasia mutated,ATM and RAD3 related,Apoptosis,ATM/ATR,AZD 0156;8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one;8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
CBNumber
CB23124835
Molecular Formula
C26H31N5O3
Formula Weight
461.56
MOL File
1821428-35-6.mol
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AZD-0156 Property

Boiling point:
628.3±55.0 °C(Predicted)
Density 
1.242±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥23.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥5.49 mg/mL in EtOH
form 
solid
pka
9.27±0.28(Predicted)
color 
White to off-white
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25648
Product name
AZD 0156
Purity
≥95%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
25648
Product name
AZD 0156
Purity
≥95%
Packaging
10mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
25648
Product name
AZD 0156
Purity
≥95%
Packaging
25mg
Price
$347
Updated
2024/03/01
Cayman Chemical
Product number
25648
Product name
AZD 0156
Purity
≥95%
Packaging
50mg
Price
$578
Updated
2024/03/01
ChemScene
Product number
CS-5889
Product name
AZD0156
Purity
99.82%
Packaging
100mg
Price
$650
Updated
2021/12/16
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AZD-0156 Chemical Properties,Usage,Production

Uses

AZD 0156 is an inhibitor of the Ataxia-Telangiectasia Mutated (ATM) protein, a signaling kinase involved in the DNA damage response.

Biological Activity

azd0156 is an atm kinase inhibitor.ataxia telangiectasia mutant (atm), a serine/threonine protein kinase from the phosphatidylinositol 3-kinase-related kinase (pikk) family of protein kinases, plays a critical role in the cellular dna damage response signalling activated by dna double strand breaks. activated atm can promote dna repair and s/g1-cell cycle checkpoints to prevent premature mitosis, maintain genomic integrity as well as promote appropriate cell survival or death pathways. thus, atm inhibitor can represent a promosing clinical opportunity to hyper-sensitize tumors to chemo/radiotherapy.

in vitro

azd0156 was identified as a first in class orally available atm inhibitor, showing sub-nanomolar potency in cell based assays of atm inhibition. moreover, azd0156 had selectivities of greater than 1000 fold over other members of the pikk family enzymes [1].

in vivo

in animal study, azd0156 displayed excellent preclinical pk properties including oral bioavailability. additionally, in mouse xenograft models, azd0156 showed robust efficacy after oral administration when combined with double strand breaks (dsb) inducing agents [1].

target

TargetValue
ATM

References

[1] kurt g. pike. identifying high quality, potent and selective inhibitors of atm kinase: discovery of azd0156. [abstract]. in: proceedings of the 107th annual meeting of the american association for cancer research; 2016 apr 16-20; new orleans, la. philadelphia (pa): aacr; cancer res 2016;76(14 suppl):abstract nr 4859.
[2] https://clinicaltrials. gov/ct2/show/nct02588105 term=azd0156&rank=1

AZD-0156 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-0156 Suppliers

China 81 India 1 United States 8 USA 1 Global 91
Hangzhou ChangCun Biotechnology Co., Ltd.
Tel
0571-; 13567100326
Fax
QQ158848739
Email
158848739@qq.com
Country
China
ProdList
108
Advantage
50
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghai XingMo Biotechnology Co., Ltd.
Tel
13524779951
Fax
QQ: 2075692521
Email
2075692521@qq.com
Country
China
ProdList
310
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55

1821428-35-6, AZD-0156Related Search:

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  • AZD-0156
  • 8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
  • 8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one
  • 8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
  • CS-2218
  • AZ 0156
  • AZ0156
  • AZ0156;AZ 0156
  • AZD-0156, >98%
  • AZD-0156;AZD 0156
  • 2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-
  • AZD-0156,inhibit,Inhibitor,AZD0156,Ataxia telangiectasia mutated,ATM and RAD3 related,Apoptosis,ATM/ATR,AZD 0156
  • 1821428-35-6