AZD2098
- Product Name
- AZD2098
- CAS No.
- 566203-88-1
- Chemical Name
- AZD2098
- Synonyms
- AZD2098;AZD 2098 NEW;AZD 2098 - Bio-X;AZD-2098 >=98% (HPLC);AZD2098, 10 mM in DMSO;AZD 2098;AZD-2098;AZD2098;2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide;Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-;AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098
- CBNumber
- CB63175527
- Molecular Formula
- C11H9Cl2N3O3S
- Formula Weight
- 334.18
- MOL File
- 566203-88-1.mol
AZD2098 Property
- Melting point:
- 185-186°C
- Boiling point:
- 489.3±55.0 °C(Predicted)
- Density
- 1.569±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- powder
- pka
- 5.56±0.40(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- SML2272
- Product name
- AZD-2098
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2025/07/31
- Product number
- SML2272
- Product name
- AZD-2098
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $423
- Updated
- 2025/07/31
- Product number
- 27633
- Product name
- AZD 2098
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 27633
- Product name
- AZD 2098
- Packaging
- 25mg
- Price
- $381
- Updated
- 2024/03/01
- Product number
- 27633
- Product name
- AZD 2098
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
AZD2098 Chemical Properties,Usage,Production
Description
AZD-2098 (566203-88-1) is a potent, orally bioavailable antagonist of CCR4 (pIC50 = 7.8(h), 8.0(r), 8.0(m), 7.6(d)).1 Inactive at CXCR1/2, CCR1, CCR2b, CCR5, CCR7, and CCR8 @ 10 μM.
Uses
AZD-2098 is a potent and selective agonist of CCR4 chemokine receptor with IC50 values ranging from 10 to 25 nM across different species. CCR4 is involved in activation and migration of Th2 lymphocytes to the lungs in response to allergens. Treating sensitised rats results in reduced inflammation of lung tissue.
Biochem/physiol Actions
AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ～120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).
in vivo
AZD2098 (73.5-5.0 μg/kg; p.o.; BID; twice a day; 1 hour before and every 12 hours after antigen challenge) exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats, and the changes are first visible at a dose of 0.22 μmol/kg and maximal at 7.5 μmol/kg[1].
| Animal Model: | Brown-Norway rats[1] |
| Dosage: | 73.5 μg/kg, 250.6 μg/kg, 735.2 μg/kg, 1.0 mg/kg, 2.5 mg/kg, 5.0 mg/kg |
| Administration: | Oral administration; twice a day; 1 hour before and every 12 hours after antigen challenge |
| Result: | Exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats. |
IC 50
CCR4
storage
Store at +4°C
References
[1] NICHOLAS KINDON. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists[J]. ACS Medicinal Chemistry Letters, 2017, 8 9: 981-986. DOI:10.1021/acsmedchemlett.7b00315
AZD2098 Preparation Products And Raw materials
Raw materials
Preparation Products
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