AZD2098

ChemicalBook > CAS DataBase List > AZD2098

Product Name: AZD2098
CAS No.: 566203-88-1
Chemical Name: AZD2098
Synonyms: AZD2098;AZD 2098 NEW;AZD-2098 >=98% (HPLC);AZD 2098;AZD-2098;AZD2098;2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide;Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-;AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098
CBNumber: CB63175527
Molecular Formula: C11H9Cl2N3O3S
Formula Weight: 334.18
MOL File: 566203-88-1.mol

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AZD2098 Property

Melting point:: 185-186°C
Boiling point:: 489.3±55.0 °C(Predicted)
Density: 1.569±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (>25 mg/ml)
form: powder
pka: 5.56±0.40(Predicted)
color: white to beige
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2272
Product name: AZD-2098
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $102
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2272
Product name: AZD-2098
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $411
Updated: 2024/03/01

Cayman Chemical

Product number: 27633
Product name: AZD 2098
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 27633
Product name: AZD 2098
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Cayman Chemical

Product number: 27633
Product name: AZD 2098
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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AZD2098 Chemical Properties,Usage,Production

Description

AZD-2098 (566203-88-1) is a potent, orally bioavailable antagonist of CCR4 (pIC50 = 7.8(h), 8.0(r), 8.0(m), 7.6(d)).1 Inactive at CXCR1/2, CCR1, CCR2b, CCR5, CCR7, and CCR8 @ 10 μM.

Uses

AZD-2098 is a potent and selective agonist of CCR4 chemokine receptor with IC50 values ranging from 10 to 25 nM across different species. CCR4 is involved in activation and migration of Th2 lymphocytes to the lungs in response to allergens. Treating sensitised rats results in reduced inflammation of lung tissue.

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ～120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

storage

Store at +4°C

References

Kindon et al. (2017), Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists; ACS Med. Chem. Lett. 8 981

AZD2098 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD2098

AZD 2098 NEW

AZD 2098;AZD-2098;AZD2098

2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide

Benzenesulfonamide, 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-

AZD-2098 >=98% (HPLC)

AZD-2098,inhibit,CC chemokine receptor,CCR,Inhibitor,AZD2098,AZD 2098

566203-88-1

C11H9Cl2N3O3S