AZD-0156

ChemicalBook > CAS DataBase List > AZD-0156

Product Name: AZD-0156
CAS No.: 1821428-35-6
Chemical Name: AZD-0156
Synonyms: AZ0156;AZ 0156;CS-2218;AZD-0156;AZD-0156, >98%;AZ0156;AZ 0156;AZD-0156;AZD 0156;AZD-0156,inhibit,Inhibitor,AZD0156,Ataxia telangiectasia mutated,ATM and RAD3 related,Apoptosis,ATM/ATR,AZD 0156;8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one;8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
CBNumber: CB23124835
Molecular Formula: C26H31N5O3
Formula Weight: 461.56
MOL File: 1821428-35-6.mol

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AZD-0156 Property

Boiling point:: 628.3±55.0 °C(Predicted)
Density: 1.242±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥23.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥5.49 mg/mL in EtOH
form: solid
pka: 9.27±0.28(Predicted)

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25648
Product name: AZD 0156
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 25648
Product name: AZD 0156
Purity: ≥95%
Packaging: 10mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 25648
Product name: AZD 0156
Purity: ≥95%
Packaging: 25mg
Price: $347
Updated: 2024/03/01

Cayman Chemical

Product number: 25648
Product name: AZD 0156
Purity: ≥95%
Packaging: 50mg
Price: $578
Updated: 2024/03/01

ChemScene

Product number: CS-5889
Product name: AZD0156
Purity: 99.82%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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AZD-0156 Chemical Properties,Usage,Production

Uses

AZD 0156 is an inhibitor of the Ataxia-Telangiectasia Mutated (ATM) protein, a signaling kinase involved in the DNA damage response.

Biological Activity

azd0156 is an atm kinase inhibitor.ataxia telangiectasia mutant (atm), a serine/threonine protein kinase from the phosphatidylinositol 3-kinase-related kinase (pikk) family of protein kinases, plays a critical role in the cellular dna damage response signalling activated by dna double strand breaks. activated atm can promote dna repair and s/g1-cell cycle checkpoints to prevent premature mitosis, maintain genomic integrity as well as promote appropriate cell survival or death pathways. thus, atm inhibitor can represent a promosing clinical opportunity to hyper-sensitize tumors to chemo/radiotherapy.

in vitro

azd0156 was identified as a first in class orally available atm inhibitor, showing sub-nanomolar potency in cell based assays of atm inhibition. moreover, azd0156 had selectivities of greater than 1000 fold over other members of the pikk family enzymes [1].

in vivo

in animal study, azd0156 displayed excellent preclinical pk properties including oral bioavailability. additionally, in mouse xenograft models, azd0156 showed robust efficacy after oral administration when combined with double strand breaks (dsb) inducing agents [1].

target

Target	Value
ATM

References

[1] kurt g. pike. identifying high quality, potent and selective inhibitors of atm kinase: discovery of azd0156. [abstract]. in: proceedings of the 107th annual meeting of the american association for cancer research; 2016 apr 16-20; new orleans, la. philadelphia (pa): aacr; cancer res 2016;76(14 suppl):abstract nr 4859.
[2] https://clinicaltrials. gov/ct2/show/nct02588105 term=azd0156&rank=1

AZD-0156 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-0156 Suppliers

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1821428-35-6, AZD-0156Related Search:

AZD8186 ALK/IGF1R inhibitor azd4635 1626387-81-2 AZD2098 AZD5153 AZD-7594 AZD-5582 AZD3839 hemifuMarate KGZHRAVDXGQUQM-WCQGTBRESA-N (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD-2858 (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate hydrochloride salt Angiontensin(1-7) AZD-4547 AZD5153 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- AZD 3759

AZD-0156

8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one

8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

CS-2218

AZ 0156

AZ0156

AZ0156;AZ 0156

AZD-0156, >98%

AZD-0156;AZD 0156

2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-

AZD-0156,inhibit,Inhibitor,AZD0156,Ataxia telangiectasia mutated,ATM and RAD3 related,Apoptosis,ATM/ATR,AZD 0156

1821428-35-6