ChemicalBook > CAS DataBase List > N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide

N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide

Product Name
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
CAS No.
827001-82-1
Chemical Name
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
Synonyms
5J 4;5J-4, 10 mM in DMSO;Orai1/CRAC Blocker, Cpd5J-4;N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide;N-((6-Hydroxynaphthalen-1-yl)carbamothioyl)furan-2-carboxamide;2-Furancarboxamide, N-[[(6-hydroxy-1-naphthalenyl)amino]thioxomethyl]-;Inhibitor,Calcium release-activated channels,CRAC Channel,CNS,Ca2+ release-activated Ca2+ channels,5J 4,inflammation,5J4,inhibit,CD4+ cells,mononuclear cell,experimental autoimmune encephalomyelitis,5J-4
CBNumber
CB13373021
Molecular Formula
C16H12N2O3S
Formula Weight
312.34
MOL File
827001-82-1.mol
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N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Property

Density 
1.459±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
8.08±0.70(Predicted)
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
H826850
Product name
N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
Packaging
100mg
Price
$1050
Updated
2021/12/16
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N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Chemical Properties,Usage,Production

Uses

N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide inhibits or blocks the calcium release-activated calcium (CRAC) channel for alleviation of autoimmune diseases.

Biological Activity

Primary Target
Orail1

in vivo

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].

Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)[1]
Dosage:2 m/kg
Administration:I.p., every alternate day for 30 days
Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.

storage

Store at -20°C

N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Suppliers

China 15 India 1 The Netherlands 1 United States 2 Global 19
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58

827001-82-1, N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamideRelated Search:


  • N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
  • 2-Furancarboxamide, N-[[(6-hydroxy-1-naphthalenyl)amino]thioxomethyl]-
  • 5J 4
  • Inhibitor,Calcium release-activated channels,CRAC Channel,CNS,Ca2+ release-activated Ca2+ channels,5J 4,inflammation,5J4,inhibit,CD4+ cells,mononuclear cell,experimental autoimmune encephalomyelitis,5J-4
  • 5J-4, 10 mM in DMSO
  • Orai1/CRAC Blocker, Cpd5J-4
  • N-((6-Hydroxynaphthalen-1-yl)carbamothioyl)furan-2-carboxamide
  • 827001-82-1