ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate

Product Name: ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
CAS No.: 139308-52-4
Chemical Name: ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
Synonyms: ethyl 3-bromo-1-methyl-pyrazole-4-carboxylate;ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate;3-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylic acid, 3-bromo-1-methyl-, ethyl ester
CBNumber: CB13376860
Molecular Formula: C7H9BrN2O2
Formula Weight: 233.06
MOL File: 139308-52-4.mol

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ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Property

Boiling point:: 290.7±20.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.40±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed

Product number: A211611
Product name: Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
Purity: 95%
Packaging: 100mg
Price: $103
Updated: 2021/12/16

Ambeed

Product number: A211611
Product name: Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
Purity: 95%
Packaging: 250mg
Price: $177
Updated: 2021/12/16

Crysdot

Product number: CD11266479
Product name: Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
Purity: 95%
Packaging: 250mg
Price: $248
Updated: 2021/12/16

Chemcia Scientific

Product number: BB20-8560
Product name: 3-Bromo-1-methyl-1H-pyrazole-4-carboxylicacidethylester
Purity: ＞95%
Packaging: 1g
Price: $300
Updated: 2021/12/16

Ambeed

Product number: A211611
Product name: Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
Purity: 95%
Packaging: 1g
Price: $376
Updated: 2021/12/16

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ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production

Synthesis

1353100-91-0

74-88-4

105486-72-4

139308-52-4

To a solution of ethyl 3-bromopyrazole-4-carboxylate (5.6 g, 25.57 mmol) in DMF (200 ml) was added iodomethane (14.52 g, 102.28 mmol, 6.37 ml) and cesium carbonate (33.32 g, 102.28 mmol). The reaction mixture was stirred at 25°C for 12 hours. After completion of the reaction, the mixture was diluted with deionized water (1000 ml) and extracted with ethyl acetate (500 ml). The organic layer was subsequently washed with saturated brine (500 ml x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was initially purified (4 g) by preparative HPLC (alkaline conditions). Further purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10/1 to 5:1) afforded ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate (1 g, yield: 16.8%) and ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate (2 g, yield: 33.6%), both as white solid.

References

[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 0506; 0936

ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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