ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Product Name
- ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
- CAS No.
- 139308-52-4
- Chemical Name
- ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Synonyms
- ethyl 3-bromo-1-methyl-pyrazole-4-carboxylate;ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate;3-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylic acid, 3-bromo-1-methyl-, ethyl ester
- CBNumber
- CB13376860
- Molecular Formula
- C7H9BrN2O2
- Formula Weight
- 233.06
- MOL File
- 139308-52-4.mol
ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Property
- Boiling point:
- 290.7±20.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.40±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- A211611
- Product name
- Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $103
- Updated
- 2021/12/16
- Product number
- A211611
- Product name
- Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $177
- Updated
- 2021/12/16
- Product number
- CD11266479
- Product name
- Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $248
- Updated
- 2021/12/16
- Product number
- BB20-8560
- Product name
- 3-Bromo-1-methyl-1H-pyrazole-4-carboxylicacidethylester
- Purity
- ＞95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- A211611
- Product name
- Ethyl3-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $376
- Updated
- 2021/12/16
ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
1353100-91-0
74-88-4
105486-72-4
139308-52-4
To a solution of ethyl 3-bromopyrazole-4-carboxylate (5.6 g, 25.57 mmol) in DMF (200 ml) was added iodomethane (14.52 g, 102.28 mmol, 6.37 ml) and cesium carbonate (33.32 g, 102.28 mmol). The reaction mixture was stirred at 25°C for 12 hours. After completion of the reaction, the mixture was diluted with deionized water (1000 ml) and extracted with ethyl acetate (500 ml). The organic layer was subsequently washed with saturated brine (500 ml x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was initially purified (4 g) by preparative HPLC (alkaline conditions). Further purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10/1 to 5:1) afforded ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate (1 g, yield: 16.8%) and ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate (2 g, yield: 33.6%), both as white solid.
References
[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 0506; 0936
ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Suppliers
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