WEHI-539 HCl
- Product Name
- WEHI-539 HCl
- CAS No.
- 2070018-33-4
- Chemical Name
- WEHI-539 HCl
- Synonyms
- WEHI-539 HCl;WEHI539 HYDROCHLORIDE ;WEHI 539 HYDROCHLORIDE;5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5~{H}-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid
- CBNumber
- CB13386520
- Molecular Formula
- C31H30ClN5O3S2
- Formula Weight
- 620.18
- MOL File
- 2070018-33-4.mol
WEHI-539 HCl Property
- storage temp.
- Store at -20°C
- solubility
- ≥28.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
N-Bromosuccinimide Price
- Product number
- A8634
- Product name
- WEHI-539hydrochloride
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $240
- Updated
- 2021/12/16
WEHI-539 HCl Chemical Properties,Usage,Production
Biological Activity
wehi-539 hydrochloride is a small-molecule inhibitor of bcl xl with ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xl inhibitor with high affinity. it interacted with the binding groove of bcl-xl with kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome c and caspase-3 processing. in bcl-xl overexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539 cannot kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xl and mcl-1. [1].
References
[1]. lessene g, czabotar pe, sleebs be, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397.
WEHI-539 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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