WEHI-539 HCl

Product Name: WEHI-539 HCl
CAS No.: 2070018-33-4
Chemical Name: WEHI-539 HCl
Synonyms: WEHI-539 HCl;WEHI539 HYDROCHLORIDE ;WEHI 539 HYDROCHLORIDE;5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5~{H}-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid
CBNumber: CB13386520
Molecular Formula: C31H30ClN5O3S2
Formula Weight: 620.18
MOL File: 2070018-33-4.mol

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WEHI-539 HCl Property

storage temp.: Store at -20°C
solubility: ≥28.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A8634
Product name: WEHI-539hydrochloride
Packaging: 10mM(in 1mL DMSO)
Price: $240
Updated: 2021/12/16

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WEHI-539 HCl Chemical Properties,Usage,Production

Biological Activity

wehi-539 hydrochloride is a small-molecule inhibitor of bcl xl with ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xl inhibitor with high affinity. it interacted with the binding groove of bcl-xl with kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome c and caspase-3 processing. in bcl-xl overexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539 cannot kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xl and mcl-1. [1].

References

[1]. lessene g, czabotar pe, sleebs be, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397.

WEHI-539 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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WEHI-539 HCl Suppliers

China 17 United States 4 Global 21

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Fax: QQ 3610331285
Email: sales@chemegen.com
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Absin Bioscience Inc.

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Shanghai hongqu biomedical technology co. LTD

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Shanghai Botuo Biotechnology Co., LTD

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MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
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2070018-33-4, WEHI-539 HClRelated Search:

4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WEHI-345 WEHI-539 WEHI-345 (analog)

WEHI-539 HCl

5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5~{H}-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid

WEHI539 HYDROCHLORIDE ;WEHI 539 HYDROCHLORIDE

2070018-33-4

C31H30ClN5O3S2