WEHI-345

Product Name: WEHI-345
CAS No.: 1354825-58-3
Chemical Name: WEHI-345
Synonyms: WHI-345;CS-2140;WEHI-345;WEHI345;WEHI 345;N-(2-(4-amino-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropyl)isonicotinamide;N-[2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-4-pyridinecarboxamide;4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-
CBNumber: CB93042231
Molecular Formula: C22H23N7O
Formula Weight: 401.46
MOL File: 1354825-58-3.mol

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WEHI-345 Property

Boiling point:: 709.0±60.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:13.5(Max Conc. mg/mL);33.63(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);4.98(Max Conc. mM)
form: A crystalline solid
pka: 12.41±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23023
Product name: WEHI-345
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 23023
Product name: WEHI-345
Purity: ≥98%
Packaging: 5mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 23023
Product name: WEHI-345
Purity: ≥98%
Packaging: 10mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 23023
Product name: WEHI-345
Purity: ≥98%
Packaging: 25mg
Price: $751
Updated: 2024/03/01

TRC

Product number: W498715
Product name: WEHI-345
Packaging: 10mg
Price: $265
Updated: 2021/12/16

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WEHI-345 Chemical Properties,Usage,Production

Uses

WEHI-345 is a potent and elective inhibitor of RIPK2.

in vivo

WEHI-345 (20 mg/kg; intraperitoneal injection; twice daily; for 6 days; C57BL/6 male mice) treatment reduces disease score, inflammatory infiltrate, histological score and recruitment of dendritic cells to the site of inflammation. And improves body weight and reduces cytokine and chemokine levels, indicating an overall improvement of the condition in experimental autoimmune encephalomyelitis (EAE)-induced wild-type C57Bl/6 mice^[1].

Animal Model:	C57BL/6 male mice (8-week-old)^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; twice daily; for 6 days
Result:	Reduced disease score, inflammatory infiltrate, histological score and recruitment of dendritic cells to the site of inflammation. And improved body weight and reduced cytokine and chemokine levels.

IC 50

RIPK2

WEHI-345 Preparation Products And Raw materials

Raw materials

Preparation Products

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WEHI-345 Suppliers

China 51 United States 9 Global 60

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
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Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
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Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3276
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1354825-58-3, WEHI-345Related Search:

4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WEHI-539 WEHI-539 HCl WEHI-345 (analog)

WEHI-345

N-[2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-4-pyridinecarboxamide

CS-2140

WHI-345

WEHI345;WEHI 345

4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-

N-(2-(4-amino-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropyl)isonicotinamide

1354825-58-3