Tucidinostat (Chidamide)
- Product Name
- Tucidinostat (Chidamide)
- CAS No.
- 1616493-44-7
- Chemical Name
- Tucidinostat (Chidamide)
- Synonyms
- CS055;TUCIDINOSTAT;D4-Chidamide;Cidabenzamine;CS055; HBI-8000;HBI-8000， CS-055;Chidamide (Tucidinostat);Tucidinostat, 10 mM in DMSO;Chidamide (Tucidinostat, HBI8000, CS 055);Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza
- CBNumber
- CB13389703
- Molecular Formula
- C22H19FN4O2
- Formula Weight
- 390.41
- MOL File
- 1616493-44-7.mol
Tucidinostat (Chidamide) Property
- Boiling point:
- 602.1±55.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 12.05±0.70(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 13686
- Product name
- Chidamide
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 13686
- Product name
- Chidamide
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 13686
- Product name
- Chidamide
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- 13686
- Product name
- Chidamide
- Packaging
- 25mg
- Price
- $266
- Updated
- 2024/03/01
- Product number
- C291980
- Product name
- Chidamide
- Packaging
- 250mg
- Price
- $1320
- Updated
- 2021/12/16
Tucidinostat (Chidamide) Chemical Properties,Usage,Production
Description
Chidamide is an inhibitor of histone deacetylases (HDACs; IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 μM for HDAC1-3, 8, 10, and 11, respectively). It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 μM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC50 = 2.1 μM). It inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 μM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI50s = >100 μM). In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.
Uses
Chidamide is a newly designed histone deacetylase inhibitor that induces an antitumor effect in various cancer by increasing the acetylation levels of histone H3 and decrease histone deacetylase (HDAC) activity, induces apoptosis. Also, it is a potential utility of Chidamide for the treatment of Myelodysplastic syndromes.
Definition
ChEBI: Chidamide is a member of benzamides.
in vivo
Tucidinostat (12.5-50 mg/kg, p.o.) dose-dependently reduces tumor size and tumor weight in mice bearing HCT-8 colorectal carcinoma, A549 lung carcinoma, BEL-7402 liver carcinoma, and MCF-7 breast carcinoma, and with no obvious body loss[1].
IC 50
HDAC3: 67 nM (IC50); HDAC10: 78 nM (IC50); HDAC1: 95 nM (IC50); HDAC2: 160 nM (IC50); HDAC11: 432 nM (IC50); HDAC8: 733 nM (IC50)
References
[1] ZHI-QIANG NING. Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity.[J]. Cancer Chemotherapy and Pharmacology, 2012, 69 4: 901-909. DOI: 10.1007/s00280-011-1766-x
[2] YING WU. Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide[J]. ACS Medicinal Chemistry Letters, 2019, 11 1: 40-44. DOI: 10.1021/acsmedchemlett.9b00407
Tucidinostat (Chidamide) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tucidinostat (Chidamide) manufacturers
- Product
- Tucidinostat (Chidamide) 1616493-44-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-29
- Product
- Tucidinostat (Chidamide) 1616493-44-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20