Tucidinostat (Chidamide)

Product Name: Tucidinostat (Chidamide)
CAS No.: 1616493-44-7
Chemical Name: Tucidinostat (Chidamide)
Synonyms: CS055;TUCIDINOSTAT;Cidabenzamine;CS055; HBI-8000;HBI-8000， CS-055;Chidamide (Tucidinostat, HBI8000, CS 055);Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza;HDAC,HBI8000,CS055,Tucidinostat,Histone deacetylases,CS-055,Inhibitor,HBI 8000,inhibit;N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide;Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-
CBNumber: CB13389703
Molecular Formula: C22H19FN4O2
Formula Weight: 390.41
MOL File: 1616493-44-7.mol

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Tucidinostat (Chidamide) Property

Boiling point:: 602.1±55.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 12.05±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 13686
Product name: Chidamide
Packaging: 25mg
Price: $266
Updated: 2024/03/01

TRC

Product number: C291980
Product name: Chidamide
Packaging: 250mg
Price: $1320
Updated: 2021/12/16

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Tucidinostat (Chidamide) Chemical Properties,Usage,Production

Description

Chidamide is an inhibitor of histone deacetylases (HDACs; IC₅₀s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 μM for HDAC1-3, 8, 10, and 11, respectively). It is selective for these HDACs over HDAC4-7 and 9 (IC₅₀s = >30 μM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC₅₀ = 2.1 μM). It inhibits cell growth in a panel of 18 cancer cell lines (GI₅₀s = 0.4-40 μM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI₅₀s = >100 μM). In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.

Uses

Chidamide is a newly designed histone deacetylase inhibitor that induces an antitumor effect in various cancer by increasing the acetylation levels of histone H3 and decrease histone deacetylase (HDAC) activity, induces apoptosis. Also, it is a potential utility of Chidamide for the treatment of Myelodysplastic syndromes.

Definition

ChEBI: Chidamide is a member of benzamides.

Tucidinostat (Chidamide) Preparation Products And Raw materials

Raw materials

Preparation Products

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Tucidinostat (Chidamide) Suppliers

China 65 India 1 United States 8 Global 74

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 10285
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
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Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
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View Lastest Price from Tucidinostat (Chidamide) manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Tucidinostat (Chidamide) 1616493-44-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

Career Henan Chemical Co

Product: Tucidinostat (Chidamide) 1616493-44-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

1616493-44-7, Tucidinostat (Chidamide)Related Search:

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TUCIDINOSTAT

N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide

Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza

CS055

CS055; HBI-8000

Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-

HBI-8000， CS-055

Chidamide (Tucidinostat, HBI8000, CS 055)

HDAC,HBI8000,CS055,Tucidinostat,Histone deacetylases,CS-055,Inhibitor,HBI 8000,inhibit

Cidabenzamine

1616493-44-7