CAY10683 (SantacruzaMate A)

Product Name: CAY10683 (SantacruzaMate A)
CAS No.: 1477949-42-0
Chemical Name: CAY10683 (SantacruzaMate A)
Synonyms: SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;CAY 10683;CAY-10683;8-Trihydroxyflavone;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE
CBNumber: CB72716623
Molecular Formula: C15H22N2O3
Formula Weight: 278.35
MOL File: 1477949-42-0.mol

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CAY10683 (SantacruzaMate A) Property

Boiling point:: 508.1±43.0 °C(Predicted)
Density: 1.087±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form: solid
pka: 12.68±0.46(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 5mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 25mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 50mg
Price: $315
Updated: 2024/03/01

Tocris

Product number: 7191
Product name: SantacruzamateA
Purity: ≥98%(HPLC)
Packaging: 10
Price: $69
Updated: 2021/12/16

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CAY10683 (SantacruzaMate A) Chemical Properties,Usage,Production

Description

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

Uses

Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Definition

ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

storage

Store at -20°C

References

1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61

CAY10683 (SantacruzaMate A) Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10683 (SantacruzaMate A) Suppliers

China 69 India 1 The Netherlands 1 United States 12 Global 83

Shanghai Boyle Chemical Co., Ltd.

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View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers

Career Henan Chemical Co

Product: CAY10683 (SantacruzaMate A) 1477949-42-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

1477949-42-0, CAY10683 (SantacruzaMate A)Related Search:

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CAY10683 (SantacruzaMate A)

ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE

N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester

Santacruzamate A (CAY10683)

SantacruzaMate A

CAY10683

CAY1083

Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester

Santacruzamate A, >98%

CAY 10683;CAY-10683

CS-1702

8-Trihydroxyflavone

1477949-42-0

Inhibitors