CAY10683 (SantacruzaMate A)
Background- Product Name
- CAY10683 (SantacruzaMate A)
- CAS No.
- 1477949-42-0
- Chemical Name
- CAY10683 (SantacruzaMate A)
- Synonyms
- SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;CAY 10683;CAY-10683;8-Trihydroxyflavone;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);SantacruzaMate A, 10 mM in DMSO
- CBNumber
- CB72716623
- Molecular Formula
- C15H22N2O3
- Formula Weight
- 278.35
- MOL File
- 1477949-42-0.mol
CAY10683 (SantacruzaMate A) Property
- Boiling point:
- 508.1±43.0 °C(Predicted)
- Density
- 1.087±0.06 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
- form
- solid
- pka
- 12.68±0.46(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $315
- Updated
- 2024/03/01
- Product number
- 7191
- Product name
- SantacruzamateA
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $69
- Updated
- 2021/12/16
CAY10683 (SantacruzaMate A) Chemical Properties,Usage,Production
Description
Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4
Uses
Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.
Definition
ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.
IC 50
HDAC2: 119 pM (IC50); HDAC6: 434 nM (IC50)
storage
Store at -20°C
Background
Santacruzamate A is a cytotoxin isolated from the Panamanian marine cyanobacterium cf. Symploca sp., and is a highly selective inhibitor of histone deacetylases, specifically HDAC2 and HDAC6. This small molecule has been shown to induce apoptosis via transcriptional inhibition of HDAC2, resulting in an increase of p21 Waf1/Cip1 and p19INK4d expression when combined with an HDAC1 inhibitor. Santacruzamate A has also demonstrated the ability to attenuate amyloid-β protein fragment-induced toxicity through enhancing endoplasmic reticulum stress tolerance in mice. Additionally, HDAC2 has been recognized as a host immune response to the influenza A virus and several other viruses, making HDAC inhibitors important compounds to study in relation to viral diseases.
References
[1] CHRISTOPHER M. PAVLIK. Santacruzamate A, a Potent and Selective Histone Deacetylase Inhibitor from the Panamanian Marine Cyanobacterium cf. Symploca sp.[J]. Journal of Natural Products , 2013, 76 11: 2026-2033. DOI:10.1021/np400198r
[2] HENGYU ZHOU. Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma[J]. Cell Proliferation, 2018, 51 3. DOI:10.1111/cpr.12447
[3] C. DAMASKOS. Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer.[J]. Anticancer research, 2017, 37 1: 35-46. DOI:10.21873/anticanres.11286
[4] LEI CHEN. Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro.[J]. ACS Applied Energy Materials, 2019: 61. DOI:10.3389/fncel.2019.00061
CAY10683 (SantacruzaMate A) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers
- Product
- CAY10683 (SantacruzaMate A) 1477949-42-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-12-04
- Product
- CAY10683 (SantacruzaMate A) 1477949-42-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05