CAY10683 (SantacruzaMate A)

Product Name: CAY10683 (SantacruzaMate A)
CAS No.: 1477949-42-0
Chemical Name: CAY10683 (SantacruzaMate A)
Synonyms: SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;CAY 10683;CAY-10683;8-Trihydroxyflavone;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE
CBNumber: CB72716623
Molecular Formula: C15H22N2O3
Formula Weight: 278.35
MOL File: 1477949-42-0.mol

More

Less

CAY10683 (SantacruzaMate A) Property

Boiling point:: 508.1±43.0 °C(Predicted)
Density: 1.087±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form: solid
pka: 12.68±0.46(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 5mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 25mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 50mg
Price: $315
Updated: 2024/03/01

Tocris

Product number: 7191
Product name: SantacruzamateA
Purity: ≥98%(HPLC)
Packaging: 10
Price: $69
Updated: 2021/12/16

More

Less

CAY10683 (SantacruzaMate A) Chemical Properties,Usage,Production

Description

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

Uses

Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Definition

ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

storage

Store at -20°C

References

1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61

CAY10683 (SantacruzaMate A) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CAY10683 (SantacruzaMate A) Suppliers

China 69 India 1 The Netherlands 1 United States 12 Global 83

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4566
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 021-13816613772 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 533
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

More

Less

View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers

Career Henan Chemical Co

Product: CAY10683 (SantacruzaMate A) 1477949-42-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

1477949-42-0, CAY10683 (SantacruzaMate A)Related Search:

DO264 METHOPRENE ACID Dequalinium chloride Fruquintinib|HMPL-013 Y27632 (hydrochloride) Axitinib PFI3 VE 822 Ruxolitinib Olaparib

CAY10683 (SantacruzaMate A)

ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE

N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester

Santacruzamate A (CAY10683)

SantacruzaMate A

CAY10683

CAY1083

Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester

Santacruzamate A, >98%

CAY 10683;CAY-10683

CS-1702

8-Trihydroxyflavone

1477949-42-0

Inhibitors