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CAY10683 (SantacruzaMate A)

Product Name
CAY10683 (SantacruzaMate A)
CAS No.
1477949-42-0
Chemical Name
CAY10683 (SantacruzaMate A)
Synonyms
SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;CAY 10683;CAY-10683;8-Trihydroxyflavone;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE
CBNumber
CB72716623
Molecular Formula
C15H22N2O3
Formula Weight
278.35
MOL File
1477949-42-0.mol
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CAY10683 (SantacruzaMate A) Property

Boiling point:
508.1±43.0 °C(Predicted)
Density 
1.087±0.06 g/cm3(Predicted)
storage temp. 
-20°
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form 
solid
pka
12.68±0.46(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15403
Product name
CAY10683
Purity
≥95%
Packaging
5mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
15403
Product name
CAY10683
Purity
≥95%
Packaging
10mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
15403
Product name
CAY10683
Purity
≥95%
Packaging
25mg
Price
$171
Updated
2024/03/01
Cayman Chemical
Product number
15403
Product name
CAY10683
Purity
≥95%
Packaging
50mg
Price
$315
Updated
2024/03/01
Tocris
Product number
7191
Product name
SantacruzamateA
Purity
≥98%(HPLC)
Packaging
10
Price
$69
Updated
2021/12/16
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CAY10683 (SantacruzaMate A) Chemical Properties,Usage,Production

Description

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

Uses

Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Definition

ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

storage

Store at -20°C

References

1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61

CAY10683 (SantacruzaMate A) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers

Career Henan Chemical Co
Product
CAY10683 (SantacruzaMate A) 1477949-42-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

1477949-42-0, CAY10683 (SantacruzaMate A)Related Search:


  • CAY10683 (SantacruzaMate A)
  • ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE
  • N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester
  • Santacruzamate A (CAY10683)
  • SantacruzaMate A
  • CAY10683
  • CAY1083
  • Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester
  • Santacruzamate A, >98%
  • CAY 10683;CAY-10683
  • CS-1702
  • 8-Trihydroxyflavone
  • 1477949-42-0
  • Inhibitors