CAY10683 (SantacruzaMate A)
- Product Name
- CAY10683 (SantacruzaMate A)
- CAS No.
- 1477949-42-0
- Chemical Name
- CAY10683 (SantacruzaMate A)
- Synonyms
- SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;CAY 10683;CAY-10683;8-Trihydroxyflavone;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE
- CBNumber
- CB72716623
- Molecular Formula
- C15H22N2O3
- Formula Weight
- 278.35
- MOL File
- 1477949-42-0.mol
CAY10683 (SantacruzaMate A) Property
- Boiling point:
- 508.1±43.0 °C(Predicted)
- Density
- 1.087±0.06 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
- form
- solid
- pka
- 12.68±0.46(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 15403
- Product name
- CAY10683
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $315
- Updated
- 2024/03/01
- Product number
- 7191
- Product name
- SantacruzamateA
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $69
- Updated
- 2021/12/16
CAY10683 (SantacruzaMate A) Chemical Properties,Usage,Production
Description
Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4
Uses
Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.
Definition
ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.
storage
Store at -20°C
References
1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61
CAY10683 (SantacruzaMate A) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers
- Product
- CAY10683 (SantacruzaMate A) 1477949-42-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05