ChemicalBook > CAS DataBase List > CAY10683 (SantacruzaMate A)

CAY10683 (SantacruzaMate A)

Product Name: CAY10683 (SantacruzaMate A)
CAS No.: 1477949-42-0
Chemical Name: CAY10683 (SantacruzaMate A)
Synonyms: SantacruzaMate A;CAY10683;Santacruzamate A (CAY10683);CAY1083;CS-1702;CAY 10683;CAY-10683;8-Trihydroxyflavone;Santacruzamate A, >98%;CAY10683 (SantacruzaMate A);SantacruzaMate A, 10 mM in DMSO
CBNumber: CB72716623
Molecular Formula: C15H22N2O3
Formula Weight: 278.35
MOL File: 1477949-42-0.mol

Less

CAY10683 (SantacruzaMate A) Property

Boiling point:: 508.1±43.0 °C(Predicted)
Density: 1.087±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form: solid
pka: 12.68±0.46(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 5mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 25mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 15403
Product name: CAY10683
Purity: ≥95%
Packaging: 50mg
Price: $315
Updated: 2024/03/01

Tocris

Product number: 7191
Product name: SantacruzamateA
Purity: ≥98%(HPLC)
Packaging: 10
Price: $69
Updated: 2021/12/16

Less

CAY10683 (SantacruzaMate A) Chemical Properties,Usage,Production

Description

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

Uses

Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Definition

ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

IC 50

HDAC2: 119 pM (IC₅₀); HDAC6: 434 nM (IC₅₀)

storage

Store at -20°C

References

[1] CHRISTOPHER M. PAVLIK. Santacruzamate A, a Potent and Selective Histone Deacetylase Inhibitor from the Panamanian Marine Cyanobacterium cf. Symploca sp.[J]. Journal of Natural Products , 2013, 76 11: 2026-2033. DOI:10.1021/np400198r
[2] HENGYU ZHOU. Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma[J]. Cell Proliferation, 2018, 51 3. DOI:10.1111/cpr.12447
[3] C. DAMASKOS. Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer.[J]. Anticancer research, 2017, 37 1: 35-46. DOI:10.21873/anticanres.11286
[4] LEI CHEN. Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro.[J]. ACS Applied Energy Materials, 2019: 61. DOI:10.3389/fncel.2019.00061

CAY10683 (SantacruzaMate A) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

CAY10683 (SantacruzaMate A) Suppliers

China 94 India 1 The Netherlands 1 United States 13 Global 109

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2391
Advantage: 55

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 1984
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7570
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3277
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1169
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Krain Pharmaceutical Technology CO.,Ltd

Tel: 18252089365
Email: Krain_kerun@163.com
Country: China
ProdList: 2507
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9847
Advantage: 58

Tianmen Hengchang Chemical Co., Ltd

Tel: 027-027-59322316 15172518801
Fax: 027-59322316
Email: 1208480077@qq.com
Country: China
ProdList: 9850
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4809
Advantage: 58

SINO High Goal Chemical Technology Co., Ltd.

Tel: 021-57646680 18306277365
Email: guoxin@chembiobanksh.com
Country: China
ProdList: 2666
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9957
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Less

View Lastest Price from CAY10683 (SantacruzaMate A) manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: CAY10683 (SantacruzaMate A) 1477949-42-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-04

Career Henan Chemical Co

Product: CAY10683 (SantacruzaMate A) 1477949-42-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

1477949-42-0, CAY10683 (SantacruzaMate A)Related Search:

Fruquintinib DO264 METHOPRENE ACID Dequalinium chloride Y27632 (hydrochloride) Axitinib PFI3 VE 822 Ruxolitinib Olaparib

CAY10683 (SantacruzaMate A)

ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE

N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester

Santacruzamate A (CAY10683)

SantacruzaMate A

CAY10683

CAY1083

Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester

Santacruzamate A, >98%

CAY 10683;CAY-10683

CS-1702

8-Trihydroxyflavone

SantacruzaMate A, 10 mM in DMSO

Santacruzamate A (CAY10683) ，S7595

1477949-42-0

Inhibitors