4'-HYDROXYCHALCONE

Product Name: 4'-HYDROXYCHALCONE
CAS No.: 2657-25-2
Chemical Name: 4'-HYDROXYCHALCONE
Synonyms: 4'-HYDROXYCHALCONE;4'-Hydroxychalcone;HYDROXYCHALCONE, 4'-;4'-Hydroxychalcone98%;4'-Hydroxychalcone>4'-Hydroxychalcone 98%;4'-Hydroxychalcone,97%;4’-Hydroxychalcone-97%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone, ≥ 95.0%
CBNumber: CB1342383
Molecular Formula: C15H12O2
Formula Weight: 224.25
MOL File: 2657-25-2.mol

More

Less

4'-HYDROXYCHALCONE Property

Melting point:: 174-178 °C
Boiling point:: 419.6±45.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
form: powder to crystal
pka: 7.72±0.15(Predicted)
color: Light orange to Yellow to Green
BRN: 2049150
InChIKey: UAHGNXFYLAJDIN-IZZDOVSWSA-N
LogP: 3.650 (est)
CAS DataBase Reference: 2657-25-2(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-37
HS Code: 29145090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003892
Product name: 4′-hydroxychalcone
Purity: AldrichCPR
Packaging: 250MG
Price: $84.9
Updated: 2024/03/01

TCI Chemical

Product number: H0945
Product name: 4'-Hydroxychalcone
Purity: >95.0%(GC)
Packaging: 5g
Price: $24
Updated: 2024/03/01

Alfa Aesar

Product number: A10838
Product name: 4'-Hydroxychalcone, 97%
Packaging: 5g
Price: $48.65
Updated: 2024/03/01

Alfa Aesar

Product number: A10838
Product name: 4'-Hydroxychalcone, 97%
Packaging: 25g
Price: $180.65
Updated: 2024/03/01

Cayman Chemical

Product number: 22898
Product name: 4'-hydroxy Chalcone
Purity: ≥98%
Packaging: 5g
Price: $44
Updated: 2024/03/01

More

Less

4'-HYDROXYCHALCONE Chemical Properties,Usage,Production

Description

4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC₅₀ = 47.3 μM) in vitro in a reversible and non-competitive manner.

Chemical Properties

yellow-cream powder

Uses

antineoplastic,

Uses

4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.

4'-HYDROXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4'-HYDROXYCHALCONE Suppliers

Americas 1 Belgium 1 China 108 Europe 2 France 1 Germany 2 India 12 Japan 2 United Kingdom 11 United States 21 USA 1 Global 162

Heze Lize Biotechnology Co., Ltd.

Tel: 10-15853052 15853052030
Email: ck@163.com15853052030
Country: China
ProdList: 299
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

More

Less

View Lastest Price from 4'-HYDROXYCHALCONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4'-HYDROXYCHALCONE 2657-25-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Career Henan Chemical Co

Product: 4'-HYDROXYCHALCONE 2657-25-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

2657-25-2, 4'-HYDROXYCHALCONERelated Search:

Apigenin 7-HYDROXYFLAVONE Hesperidin methylchalcone AVICULARIN MORIN Rutin 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE Myricetin HOMOBUTEIN Quercetin Chrysin Galangin 4'-METHOXYCHALCONE 4'-HYDROXYCHALCONE 7,8-Dihydroxyflavone Diosmin Isoliquiritigenin 4-BUTYL-4'-HYDROXYCHALCONE

2-Benzal-4'-hydroxyacetophenone 2-Benzylidene-4'-hydroxyacetophenone

1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one

1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one

4'-Hydroxychalcone,97%

4'-Hydroxychalcone 98%

HYDROXYCHALCONE, 4-(RG)

4'-Hydroxychalcone98%

HYDROXYCHALCONE, 4'-

BENZYLIDENE-(4-HYDROXYACETOPHENONE)

BENZYLIDENE-4'-HYDROXYACETOPHENONE

4'-HYDROXYCHALCONE

2-BENZAL-4'-HYDROXYACETOPHENONE

2-BENZYLIDENE-4'-HYDROXYACETOPHENONE

(E)-1-(4-hydroxyphenyl)-3-phenyl-2-propen-1-one

(E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one

1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one, 4-Cinnamoylphenol

4'-Hydroxychalcone&gt

2-Propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl-

4'-Hydroxychalcone, ≥ 95.0%

4'-Hydroxychalcone

4’-Hydroxychalcone-97%

2657-25-2

C15H12O2

Flavonoids

Chalcones

Biochemistry

Flavonoids