ChemicalBook > CAS DataBase List > 4'-HYDROXYCHALCONE

4'-HYDROXYCHALCONE

Product Name
4'-HYDROXYCHALCONE
CAS No.
2657-25-2
Chemical Name
4'-HYDROXYCHALCONE
Synonyms
4'-HYDROXYCHALCONE;4'-Hydroxychalcone;HYDROXYCHALCONE, 4'-;4'-Hydroxychalcone98%;4'-Hydroxychalcone>4'-Hydroxychalcone 98%;4'-Hydroxychalcone,97%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone, ≥ 95.0%;2-BENZAL-4'-HYDROXYACETOPHENONE
CBNumber
CB1342383
Molecular Formula
C15H12O2
Formula Weight
224.25
MOL File
2657-25-2.mol
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4'-HYDROXYCHALCONE Property

Melting point:
174-178 °C
Boiling point:
419.6±45.0 °C(Predicted)
Density 
1.191±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
form 
powder to crystal
pka
7.72±0.15(Predicted)
color 
Light orange to Yellow to Green
BRN 
2049150
InChIKey
UAHGNXFYLAJDIN-IZZDOVSWSA-N
LogP
3.650 (est)
CAS DataBase Reference
2657-25-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-37
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS003892
Product name
4′-hydroxychalcone
Purity
AldrichCPR
Packaging
250MG
Price
$84.9
Updated
2024/03/01
TCI Chemical
Product number
H0945
Product name
4'-Hydroxychalcone
Purity
>95.0%(GC)
Packaging
5g
Price
$24
Updated
2024/03/01
Alfa Aesar
Product number
A10838
Product name
4'-Hydroxychalcone, 97%
Packaging
5g
Price
$48.65
Updated
2024/03/01
Alfa Aesar
Product number
A10838
Product name
4'-Hydroxychalcone, 97%
Packaging
25g
Price
$180.65
Updated
2024/03/01
Cayman Chemical
Product number
22898
Product name
4'-hydroxy Chalcone
Purity
≥98%
Packaging
5g
Price
$44
Updated
2024/03/01
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4'-HYDROXYCHALCONE Chemical Properties,Usage,Production

Description

4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.

Chemical Properties

yellow-cream powder

Uses

antineoplastic,

Uses

4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.

4'-HYDROXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-HYDROXYCHALCONE Suppliers

Americas 1 Belgium 1 China 97 Europe 2 France 1 Germany 2 India 12 Japan 2 United Kingdom 11 United States 20 USA 1 Global 150
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from 4'-HYDROXYCHALCONE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4'-HYDROXYCHALCONE 2657-25-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Career Henan Chemical Co
Product
4'-HYDROXYCHALCONE 2657-25-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

2657-25-2, 4'-HYDROXYCHALCONERelated Search:

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