4'-HYDROXYCHALCONE
- Product Name
- 4'-HYDROXYCHALCONE
- CAS No.
- 2657-25-2
- Chemical Name
- 4'-HYDROXYCHALCONE
- Synonyms
- 4'-HYDROXYCHALCONE;4'-Hydroxychalcone;HYDROXYCHALCONE, 4'-;4'-Hydroxychalcone98%;4'-Hydroxychalcone>4'-Hydroxychalcone 98%;4'-Hydroxychalcone,97%;4’-Hydroxychalcone-97%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone, ≥ 95.0%
- CBNumber
- CB1342383
- Molecular Formula
- C15H12O2
- Formula Weight
- 224.25
- MOL File
- 2657-25-2.mol
4'-HYDROXYCHALCONE Property
- Melting point:
- 174-178 °C
- Boiling point:
- 419.6±45.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
- form
- powder to crystal
- pka
- 7.72±0.15(Predicted)
- color
- Light orange to Yellow to Green
- BRN
- 2049150
- InChIKey
- UAHGNXFYLAJDIN-IZZDOVSWSA-N
- LogP
- 3.650 (est)
- CAS DataBase Reference
- 2657-25-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-37
- HS Code
- 29145090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS003892
- Product name
- 4′-hydroxychalcone
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $84.9
- Updated
- 2024/03/01
- Product number
- H0945
- Product name
- 4'-Hydroxychalcone
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $24
- Updated
- 2024/03/01
- Product number
- A10838
- Product name
- 4'-Hydroxychalcone, 97%
- Packaging
- 5g
- Price
- $48.65
- Updated
- 2024/03/01
- Product number
- A10838
- Product name
- 4'-Hydroxychalcone, 97%
- Packaging
- 25g
- Price
- $180.65
- Updated
- 2024/03/01
- Product number
- 22898
- Product name
- 4'-hydroxy Chalcone
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $44
- Updated
- 2024/03/01
4'-HYDROXYCHALCONE Chemical Properties,Usage,Production
Description
4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.
Chemical Properties
yellow-cream powder
Uses
antineoplastic,
Uses
4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).
Definition
ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.
4'-HYDROXYCHALCONE Preparation Products And Raw materials
Raw materials
Preparation Products
4'-HYDROXYCHALCONE Suppliers
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View Lastest Price from 4'-HYDROXYCHALCONE manufacturers
- Product
- 4'-HYDROXYCHALCONE 2657-25-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 4'-HYDROXYCHALCONE 2657-25-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19