ChemicalBook > CAS DataBase List > 4-BROMO-6-METHOXYINDOLE

4-BROMO-6-METHOXYINDOLE

Product Name
4-BROMO-6-METHOXYINDOLE
CAS No.
393553-55-4
Chemical Name
4-BROMO-6-METHOXYINDOLE
Synonyms
4-BROMO-6-METHOXYINDOLE;4-BROMO-6-METHYLOXY INDOLE;4-bromo-6-methoxy-1H-indole;4-broMo-6-Methyloxyl indole;1H-Indole, 4-broMo-6-Methoxy-
CBNumber
CB1348446
Molecular Formula
C9H8BrNO
Formula Weight
226.07
MOL File
393553-55-4.mol
More
Less

4-BROMO-6-METHOXYINDOLE Property

Boiling point:
346.8±22.0 °C(Predicted)
Density 
1.591±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
16.29±0.30(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C9H8BrNO/c1-12-6-4-8(10)7-2-3-11-9(7)5-6/h2-5,11H,1H3
InChIKey
CZJYKEPYJHPVOD-UHFFFAOYSA-N
SMILES
N1C2=C(C(Br)=CC(OC)=C2)C=C1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B429763
Product name
4-bromo-6-methoxy-1H-indole
Packaging
1mg
Price
$45
Updated
2021/12/16
TRC
Product number
B429763
Product name
4-bromo-6-methoxy-1H-indole
Packaging
2mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0320033
Product name
4-BROMO-6-METHOXYINDOLE
Purity
95.00%
Packaging
5MG
Price
$497.1
Updated
2021/12/16
AK Scientific
Product number
5147AB
Product name
4-Bromo-6-methoxy-1H-indole
Packaging
5g
Price
$1308
Updated
2021/12/16
Ambeed
Product number
A171194
Product name
4-Bromo-6-methoxy-1H-indole
Purity
98%
Packaging
100mg
Price
$74
Updated
2021/12/16
More
Less

4-BROMO-6-METHOXYINDOLE Chemical Properties,Usage,Production

Synthesis

1431711-54-4

393553-55-4

General procedure for the synthesis of 4-bromo-6-methoxy-1H-indole from the compound (CAS: 1431711-54-4): (b) N-(3-bromo-5-methoxyphenyl)-N-hydroxyacetamide (360 mg, 1.384 mmol) was dissolved in vinyl acetate (1.92 mL) followed by addition of Li2PdCl4 (18.2 mg, 69 μmol). The reaction mixture was stirred at 60°C for 3 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and brine, the organic layer was separated and concentrated under reduced pressure to give a solid. The solid was dissolved in methanol (20 mL), 1N NaOH aqueous solution (2.61 mL, 2.61 mmol) was added and stirred for 2 hours at room temperature. The reaction mixture was quenched with 2N HCl aqueous solution (1.3 mL, 2.6 mmol) followed by addition of sodium carbonate (500 mg). After addition of ethyl acetate (50 mL), the organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. The residue was purified by column chromatography (20 g silica gel, ethyl acetate/heptane, gradient from 0/100 to 1/4) to afford the title compound as a liquid (145 mg, 46% yield, two steps).1H-NMR (600 MHz; DMSO-d6): δ 11.26 (brs, 1H), 7.31 (dd, 1H), 6.93 (d, 1H), and 6.90 (d, 1H), 6.29 (dd, 1H), 3.78 (s, 3H).

References

[1] Patent: WO2013/61305, 2013, A1. Location in patent: Page/Page column 45; 46

4-BROMO-6-METHOXYINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-BROMO-6-METHOXYINDOLE Suppliers

China 70 India 1 United Kingdom 3 United States 7 Global 81
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
Atlantic SciTech Group, Inc.
Tel
--
Fax
--
Email
sales@astginc.com
Country
United States
ProdList
2308
Advantage
43
More
Less

View Lastest Price from 4-BROMO-6-METHOXYINDOLE manufacturers

Career Henan Chemical Co
Product
4-BROMO-6-METHOXYINDOLE 393553-55-4
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-12

393553-55-4, 4-BROMO-6-METHOXYINDOLERelated Search:

6-BROMO-4-METHOXYINDOLE 3-Bromo-5-methoxyindole 3-Bromo-5-methoxyindole, N-BOC protected 98%,3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER,3-BROMO-5-METHOXYINDOLE, N-BOC PROTECTED 7-BROMO-4-METHOXYINDOLE 4-BROMO-6,7-DIMETHOXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER 4-BROMO-6,7-DIMETHOXY-1H-INDOLE-2-CARBOXYLIC ACID 5-Bromo-8H-1,3-dioxa-8-aza-as-indacene-7-carboxylic acid 4-BROMO-6-METHOXYINDOLE 4-BROMO-7-ETHOXY-6-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER 5-BROMO-8H-1,3-DIOXA-8-AZA-AS-INDACENE-7-CARBOXYLIC ACID METHYL ESTER BROMOHARMALINE, HBR 4-BROMO-6-ETHOXY-7-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID 4-BROMO-7-ETHOXY-6-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID BROMOHARMINE HBR

  • 4-BROMO-6-METHYLOXY INDOLE
  • 4-bromo-6-methoxy-1H-indole
  • 1H-Indole, 4-broMo-6-Methoxy-
  • 4-broMo-6-Methyloxyl indole
  • 4-BROMO-6-METHOXYINDOLE
  • 393553-55-4