Chemical Properties Uses Toxicity Preparation
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Propoxur

Chemical Properties Uses Toxicity Preparation
Product Name
Propoxur
CAS No.
114-26-1
Chemical Name
Propoxur
Synonyms
PHC;phc7;IMPC;IPMC;Bifex;Bolfo;oms33;Tugen;UNDEN;Boruho
CBNumber
CB1348734
Molecular Formula
C11H15NO3
Formula Weight
209.24
MOL File
114-26-1.mol
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Propoxur Property

Melting point:
91°C
Boiling point:
348.6°C (rough estimate)
Density 
1.1200
vapor pressure 
1.3 x 10-3 Pa (20 °C)
refractive index 
1.5080 (estimate)
Flash point:
-18 °C
storage temp. 
2-8°C
pka
12.28±0.46(Predicted)
form 
Minute Crystals
Water Solubility 
Slightly soluble. 0.2 g/100 mL
Merck 
13,7929
BRN 
1879891
Exposure limits
OSHA TWA: 0.5 mg/m3; ACGIH TLV: TWA 0.5 mg/m3.
CAS DataBase Reference
114-26-1
NIST Chemistry Reference
2-Isopropoxyphenyl N-methylcarbamate(114-26-1)
EPA Substance Registry System
Propoxur (114-26-1)
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Safety

Hazard Codes 
T;N,N,T,Xn,F
Risk Statements 
25-50/53-67-65-38-11
Safety Statements 
37-45-60-61-62
RIDADR 
UN 2811/2588
WGK Germany 
3
RTECS 
FC3150000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
114-26-1(Hazardous Substances Data)
Toxicity
LD50 orally in male, female rats: 83, 86 mg/kg (Gaines)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H311Toxic in contact with skin

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45644
Product name
Propoxur
Purity
PESTANAL
Packaging
250mg
Price
$42.2
Updated
2021/12/16
Cayman Chemical
Product number
25628
Product name
Propoxur
Purity
≥95%
Packaging
100mg
Price
$90
Updated
2021/12/16
Cayman Chemical
Product number
25628
Product name
Propoxur
Packaging
25mg
Price
$25
Updated
2021/03/22
Cayman Chemical
Product number
25628
Product name
Propoxur
Packaging
50mg
Price
$48
Updated
2021/03/22
TRC
Product number
P830800
Product name
Propoxur
Packaging
1g
Price
$135
Updated
2021/12/16
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Propoxur Chemical Properties,Usage,Production

Chemical Properties

The pure propoxur is white crystalline powder. m.p.91.5℃(industrial products84~87℃) and vapour pressure 1.33Pa (120℃). It can be dissolved in most polar organic solvents, and the solubility in water is 0.2%. It is easy to hydrolyze under alkaline conditions and the half-life of pH at 10 time is 40min (20℃).

Uses

Quick acting, long-acting carbamate insecticide. It has the effect of touch and kill, stomach poison and fumigation, and there is no internal absorption. It is mainly used for prevention and control of rice stem borer and rice leafhopper, planthopper, cotton aphid, scale insect, rust ticks, cereal pests and sanitary insect pest  in crops. It can kill in vitro parasites, family health pests (mosquitoes, flies, cockroaches, etc.) and storehouse pests.

Toxicity

The acute oral LD50 is 90 to 128mg/kg for the male rats,104mg/kg for the female rats and 100 to 109mg/kg for the male mice. The acute transdermal LD50 is 800 ~ 1000mg/kg for the rats. In the 2 year feeding test, the non action dose is 800 ~ 1000mg/kg. For carp it is LC50>10mg/L. The acute oral LD50 is 15 ~ 30mg/kg for cowbirds. It is of high toxicity to bees.

Preparation

The following two methods can be adopted and the reaction is:

Description

Propoxur, 2-isopropoxyphenyl methylcarbamate (IUPAC),forms colorless crystals, which are moderately soluble in most organic solvents.

Description

Propoxur is a carbamate insecticide and an inhibitor of acetylcholinesterase. It is lethal to German cockroaches (B. germanica) with LD50 values of 2.45, 4.73, and 1.06 μg per insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively. Propoxur induces lactate dehydrogenase (LDH) release from and inhibits the growth of flounder gill cells (IC50s = 86.59 and 89.96 μg/ml, respectively) via induction of necrosis. It also induces yolk sac and pericardial edema in zebrafish embryos when used at concentrations of 100 and 200 μg/ml. Propoxur (8.3 mg/kg) inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats.

Chemical Properties

White, crystalline powder; odorless. Soluble in most alcohols; very slightly solublein water; unstable in highly alkaline media; stableunder normal conditions.

Chemical Properties

Propoxur is a white to tan crystalline solid or powder. Faint characteristic odor

Uses

Propoxur is a non-systematic carbamate insecticide. Propoxur is used against a wide range of insects such as fleas, mosquitoes, ants, gypsy moths, and other agricultural pests. Propoxur functions by r eversibly inactivating the enzyme acetylcholinesterase in insects.

Uses

Insecticide used for control of chewing and sucking insects in fruits, vegetables, ornamentals and forestry.

Uses

Propoxur is an insecticide with contact and stomach action. It is mainly used in food storage areas. It also controls chewing and sucking pests on a wide range of crops.

Definition

ChEBI: A carbamate ester that is phenyl methylcarbamate substituted at position 2 by a propan-2-yloxy group.

Preparation

Propoxur is prepared by reaction of 2-isopropoxyphenol with methylisocyanate.

General Description

White to tan crystalline powder with a faint, characteristic odor. Used as an insecticide.

Reactivity Profile

Propoxur is incompatible with the following: Strong oxidizers, alkalis [Note: Emits highly toxic methyl isocyanate fumes when heated to decomposition.] .

Hazard

Toxic by ingestion and inhalation. Cholinesterase inhibitor. Possible carcinogen.

Health Hazard

A highly toxic substance by ingestion, andpossibly by most other routes of exposure;moderately toxic by inhalation and skin contact; cholinesterase inhibitor; toxic effects aresimilar to those of other carbamate pesticidesand include excessive salivation, lacrimation, slow heart rate, blurred vision, twitchingof muscle and lack of coordination, nausea,weakness, diarrhea and abdominal pain; oralintake of probably 1.5–3 g could be fatal toadult humans; a teratogenic substance, producing adverse reproductive effects in experimental animals.
LD50 oral (rat): 70 mg/kg
LD50 skin (rat): 800 mg/kg
LC50 inhalation (rat): 1440 mg/m3/1 hr.

Agricultural Uses

Insecticide, Molluscicide: Not approved for use in EU countries. A non-systemic insecticide compatible with most fungicides and insecticides except those that are alkaline. It is often used in combination with azinphosmethyl, chlorpyrifos, cyfluthrin, dichlorvos, disulfoton or methocarb. It is used on sugar cane, cocoa, pome and stone fruit, grapes, maize, hops, rice, sugar beets, vegetables, cotton, and forestry and ornamentals to control pests such as chewing and sucking insects, ants, crickets, flies, mosquitoes, millepedes, jassids and cockroaches.

Trade name

(There are currently 695 registered active and/or canceled and/or transferred products in the U.S.) ARPROCARB®; BAY®; BAY® 5122; BAYER®; BAYER® B 5122; BAYGON®; BIFEX®; BLATTANEX®; BLATTOSEP®; BOLFO®; BO Q 5812-315®; BORUHO®; BORUHO® 50; BRIFUR®; BRYGOU®; CHEMAGRO® 9010; COMPOUND 39007; DALF DUST®; INVISI-GARD®; PILLARGON®; PRENTOX CARBAMATE®; PROPOGON®; PROPOTOX®; PROPOXYLOR®; PROPYON®; RHODEN®; SENDRAN®; SUNCIDE®; TENDEX®; TUGEN®; UNDEN®; UNDENE®

Potential Exposure

Personnel engaged in the manufacture, formulation and application of this organonitrogen agricul- tural chemical and pesticide.

Environmental Fate

Groundwater. According to the U.S. EPA (1986) propoxur has a high potential to leach to groundwater.
Photolytic. Though no products were identified, the half-life in UV irradiated water (λ >290 nm) was 87.9 hours (Jensen-Korte et al., 1987). When propoxur in ethanol was irradiated by UV light, only one unidentified cholinesterase inhibitor formed. Exposure to sunlight for 3 hours yielded no photodecomposition products (Crosby et al., 1965).
Chemical/Physical. Decomposes at elevated temperatures forming methyl isocyanate (Windholz et al., 1983) and nitrogen oxides (Lewis, 1990). Hydrolyzes in water to 1- naphthol and 2-isopropoxyphenol (Miles et al., 1988). At pH 6.9, half-lives of 78 and 124 days were reported under aerobic and anaerobic conditions, respectively (Kanazawa, 1987). Miles et al. (1988) studied the rate of hydrolysis of propoxur in phosphate-buffered water (0.01 M) at 26°C with and without a chlorinating agent (10 mg/L hypochlorite solution). The hydrolysis half-lives at pH 7 and 8 with and without chlorine were 3.5 and 10.3 days and 0.05 and 1.2 days, respectively (Miles et al., 1988). The reported hydrolysis half-lives of propoxur in water at pH 8, 9 and 10 were 16.0 days, 1.6 days and 4.2 hours, respectively (Aly and El-Dib, 1971). In a 0.50 N sodium hydroxide solution at 20°C, the hydrolysis half-life was reported to be 3.0 days (El-Dib and Aly, 1976).

Metabolic pathway

The principal pathways of propoxur metabolism in plants and animals are deisopropylation, hydrolysis of the carbamate ester to form a phenol and conjugation. Minor metabolites are formed by hydroxylation of the N-methyl group and the phenyl ring. Only insects form metabolites hydroxylated at the isopropoxy group.

Shipping

UN2757 Carbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Degradation

Propoxur is hydrolysed by strong alkalis. DT50 values at pH 7 and 9 (22°C) were 93 days and 30 hours (PM). Propoxur was hydrolysed in neutral aerated river water (half-life <2 days at 25 °C) (Kuhr and Dorough, 1976).
It is not rapidly photodegraded in aqueous solutions (PM) and is more stable than carbaryl (Crosby et al., 1965). Solutions of unlabelled propoxur in isopropanol, cyclohexane or cyclohexene were irradiated for 48 hours with a high-pressure Hg lamp with light of wavelength less than 280 nm filtered out. Analysis of samples was by HPLC. Photodecomposition was faster in isopropanol than in the hydrocarbon solvents. The main pathway of photodecomposition (see Scheme 1) was β-cleavage of the carbamate ester group to form isopropyl phenyl ether (2). 2-Isopropoxyphenol (3) was detected as a trace product (Schwack and Kopf, 1992).

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alkalis, heat, and mois- ture. Emits highly toxic methyl isocyanate fumes when heated to decomposition.

Waste Disposal

In accordance with 40CFR165, follow recommendations for the disposal of pes- ticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contact- ing your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations govern- ing storage, transportation, treatment, and waste disposal.

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Propoxur Suppliers

Wuhan plov Biotechnology Co., Ltd
Tel
176-12776-928
Fax
17612776928
Email
17612776928@qq.com
Country
China
ProdList
4983
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Wuhan Wei Shunda Technology Development Co., Ltd.
Tel
86-027-88774375
Fax
86-027-88416321
Email
mwmwhot@163.com
Country
China
ProdList
233
Advantage
65
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
BEST-REAGENT
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
Country
China
ProdList
11718
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9686
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2985
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
028-85911938-
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9750
Advantage
55
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View Lastest Price from Propoxur manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Propoxur 114-26-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Propoxur 114-26-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
qingdao trust agri chemical co.,ltd
Product
Propoxur 114-26-1
Price
US $8.00/Kg/Drum
Min. Order
100KG
Purity
99%
Supply Ability
200tons
Release date
2021-09-27

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