Description Uses Preparation
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Methylaminoformyl chloride

Description Uses Preparation
Product Name
Methylaminoformyl chloride
CAS No.
6452-47-7
Chemical Name
Methylaminoformyl chloride
Synonyms
N-Methylchloroformamide;Methylcarbamic chloride;METHYLCARBAMOYLCHLORIDE;METHYLAMINOFORMYL CHLORIDE;Carbamic chloride, methyl-;N-Methylcarbamoyl chloride;N-(Chloroformyl)methylamine;n-methylaminoformyl chloride;Methylcarbamic acid chloride;Carbamic chloride, N-methyl-
CBNumber
CB5512113
Molecular Formula
C2H4ClNO
Formula Weight
93.51
MOL File
6452-47-7.mol
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Methylaminoformyl chloride Property

Melting point:
45°C
Boiling point:
93°C (dec.)
Density 
1.185±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
10.67±0.46(Predicted)
CAS DataBase Reference
6452-47-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

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Methylaminoformyl chloride Chemical Properties,Usage,Production

Description

Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.

Uses

Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.

Preparation

Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009

Methylaminoformyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Methylaminoformyl chloride Suppliers

Shanghai Yichang Chemical Co., Ltd.
Tel
021-56145923-
Email
sales@yichangchemical.com
Country
China
ProdList
112
Advantage
58
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 qq:2355568890
Fax
0086-21-50182339
Email
sales@demochem.com; export1@demochem.com
Country
China
ProdList
2582
Advantage
57
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
Advantage
62
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43504
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12356
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078;021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100-
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9636
Advantage
66
Secco work (Beijing) chemical technology co., LTD
Tel
010-69755668
Fax
010-69755668
Email
343367102@QQ.COM
Country
China
ProdList
3529
Advantage
54
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005;021-58099637-8009
Fax
021-58099609
Email
bin.wu@shlschem.com;sales@shlschem.com
Country
China
ProdList
9827
Advantage
59
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View Lastest Price from Methylaminoformyl chloride manufacturers

Career Henan Chemical Co
Product
Methylaminoformyl Chloride 6452-47-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-09

6452-47-7, Methylaminoformyl chlorideRelated Search:


  • METHYLCARBAMOYLCHLORIDE
  • METHYLAMINOFORMYL CHLORIDE
  • n-methylaminoformyl chloride
  • Methylcarbamic chloride
  • N-Methylchloroformamide
  • Methylcarbamic acid chloride
  • N-(Chloroformyl)methylamine
  • N-Methylcarbamoyl chloride
  • CarbaMic chloride,Methyl- (9CI)
  • Carbamic chloride, N-methyl-
  • Carbamic chloride, methyl-
  • 6452-47-7
  • CH3NHCOCl
  • Agrochemicals