Description Uses Preparation
ChemicalBook > CAS DataBase List > Methylaminoformyl chloride

Methylaminoformyl chloride

Description Uses Preparation
Product Name
Methylaminoformyl chloride
CAS No.
6452-47-7
Chemical Name
Methylaminoformyl chloride
Synonyms
Methylcarbamic chloride;n-methylaminoformyl chloride;N-Methylchloroformamide;METHYLCARBAMOYLCHLORIDE;METHYLAMINOFORMYL CHLORIDE;Carbamic chloride, methyl-;N-Methylcarbamoyl chloride;N-(Chloroformyl)methylamine;Methylcarbamic acid chloride;Carbamic chloride, N-methyl-
CBNumber
CB5512113
Molecular Formula
C2H4ClNO
Formula Weight
93.51
MOL File
6452-47-7.mol
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Methylaminoformyl chloride Property

Melting point:
45°C
Boiling point:
93°C (dec.)
Density 
1.185±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Acetonitrile, Chloroform (Slightly), DMSO
pka
10.67±0.46(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Air Sensitive, Hygroscopic, Moisture Sensitive, Volatile
CAS DataBase Reference
6452-47-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS009330
Product name
methylaminoformyl chloride
Purity
AldrichCPR
Packaging
100MG
Price
$106
Updated
2023/06/20
TRC
Product number
M295225
Product name
MethylcarbamoylChloride
Packaging
25g
Price
$155
Updated
2021/12/16
AK Scientific
Product number
C419
Product name
N-Methylaminoformylchloride
Packaging
5g
Price
$49
Updated
2021/12/16
Oakwood
Product number
358405
Product name
N-Methylcarbamoylchloride
Purity
tech
Packaging
5g
Price
$49
Updated
2021/12/16
AK Scientific
Product number
C419
Product name
N-Methylaminoformylchloride
Packaging
25g
Price
$70
Updated
2021/12/16
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Methylaminoformyl chloride Chemical Properties,Usage,Production

Description

Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.

Uses

Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.

Preparation

Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].

Uses

Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009

Methylaminoformyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methylaminoformyl chloride manufacturers

Hebei Duling International Trade Co. LTD
Product
Methylaminoformyl chloride 6452-47-7
Price
US $10.50/kg
Min. Order
1kg
Purity
90%
Supply Ability
500TM/month
Release date
2022-10-21
Career Henan Chemical Co
Product
Methylaminoformyl Chloride 6452-47-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-09

6452-47-7, Methylaminoformyl chlorideRelated Search:


  • METHYLCARBAMOYLCHLORIDE
  • METHYLAMINOFORMYL CHLORIDE
  • n-methylaminoformyl chloride
  • Methylcarbamic chloride
  • N-Methylchloroformamide
  • Methylcarbamic acid chloride
  • N-(Chloroformyl)methylamine
  • N-Methylcarbamoyl chloride
  • CarbaMic chloride,Methyl- (9CI)
  • Carbamic chloride, N-methyl-
  • Carbamic chloride, methyl-
  • Methylaminoformyl chloride,90%
  • Dienestrol Impurity 1 (Z,Z-Dienestrol)
  • 6452-47-7
  • CH3NHCOCl
  • Agrochemicals